TRPV1 - transient receptor potential cation channel subfamily V member 1 Gene

Also Known as VR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7442

About TRPV1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:3,565,446-3,609,411 (from NCBI)

This gene has 10 transcripts (splice variants), 134 orthologues and 5 paralogues. Ubiquitous expression in duodenum (RPKM 3.6), ovary (RPKM 3.0) and 25 other tissues.

Summary

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

TRPV1 Products (4)

mRNA	Protein	Name
NM_018727.5	NP_061197.4	transient receptor potential cation channel subfamily V member 1
NM_080704.4	NP_542435.2	transient receptor potential cation channel subfamily V member 1
NM_080705.4	NP_542436.2	transient receptor potential cation channel subfamily V member 1
NM_080706.3	NP_542437.2	transient receptor potential cation channel subfamily V member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables extracellular ligand-gated monoatomic ion channel activity	IDA IDA: Inferred from direct assay	11226139	GOA
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	19801576	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29656858	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion import across plasma membrane	IDA IDA: Inferred from direct assay	11226139	GOA
involved in cellular response to acidic pH	IDA IDA: Inferred from direct assay	11226139	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	11226139	GOA
involved in response to capsazepine	IMP IMP: Inferred from mutant phenotype	11226139	GOA
acts upstream of or within thermoception	IDA IDA: Inferred from direct assay	10201375	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	10201375	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPV1 Protein Structure

Ank_2

0
200
400
600
800
839 a.a.

Protein Preferred Names	Protein Names
transient receptor potential cation channel subfamily V member 1	OTRPC1

Related Diseases

Diseases	Alias
Pulpitis	Pulp Stones Pulpitis Nos
Burning Mouth Syndrome	Orodynia Stomatodynia Stomatopyrosis Bms Burning Mouth Disorder Oral Dysesthesia Sore Mouth Syndrome Bms - [Burning Mouth Syndrome]
Bladder Disease	Bladder Diseases Urinary Bladder Diseases Urinary Bladder Disease
Dentin Sensitivity	Sensitive Dentin
Diabetic Neuropathy	Diabetic Neuropathies
Cystitis	Infective Cystitis Urocystitis Pyocystitis
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Somatoform Disorder	Physiological Malfunction Arising From Mental Factor Psychosomatic Disorder Psychophysiologic Disorders
Hyperhidrosis, Gustatory	Frey Syndrome Gustatory Sweating Auriculotemporal Nerve Syndrome Gustatory Hyperhidrosis Frey'S Syndrome Sweating, Gustatory HYPRG Baillarger Syndrome Hyperhidrosis Gustatory Auriculotemporal Syndrome
Pain Agnosia	Analgesia
Mononeuritis Of Lower Limb
Herpes Zoster	Shingles Zoster Herpes Zona Herpes Zoster Disease Zona Zoster Herpes Zoster Of Skin And Mucous Membranes Zoster Nos Zoster With Nervous System Involvement
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Familial Episodic Pain Syndrome	Feps
Interstitial Cystitis	Bladder Pain Syndrome Painful Bladder Syndrome Ulcerative Cystitis Ic/Bps Ic/Pbs Interstitial Cystitis/Bladder Pain Syndrome Interstitial Cystitis/Painful Bladder Syndrome Cystitis, Interstitial Chronic Interstitial Cystitis Pelvic Congestion Syndrome Trigonitis
Photokeratitis
Detrusor Sphincter Dyssynergia	Detrusor And Sphincter Dyssynergia
Lesion Of Sciatic Nerve	Nerve Lesion Sciatic Sciatic Neuropathy
Trigeminal Nerve Disease	Trigeminal Nerve Diseases Disorders Of 5th Cranial Nerve Disorders Of The Fifth Cranial Nerve
Sciatic Neuropathy
Cough Variant Asthma
Cystinosis	Cystine Storage Disease Cystine Diathesis Cystine Disease Cystinoses Protein Defect Of Cystin Transport Cystin Transport, Protein Defect Of Nephropathic Cystinosis Protein Defect Of Cystine Transport
Complex Regional Pain Syndrome	Complex Regional Pain Syndromes Reflex Sympathetic Dystrophy Crps
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques	Olmsted Syndrome Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques Palmoplantar And Periorificial Keratoderma Olms
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Vasomotor Rhinitis	Rhinitis, Vasomotor Rhinitis Vasomotor Vmr - [Vasomotor Rhinitis]
Malignant Hyperthermia	Anesthesia Related Hyperthermia Malignant Hyperpyrexia Due To Anesthesia Hyperpyrexia, Malignant Hyperthermia, Malignant Malignant Hyperpyrexia Mhs Malignant Fever
Paine Syndrome	Pain Disorder Pain Microcephaly With Spastic Diplegia Pain Syndrome
Episodic Pain Syndrome, Familial, 1	FEPS1 Familial Episodic Pain Syndrome With Predominantly Upper Body Involvement Familial Episodic Pain Syndrome 1
Ocular Hyperemia	Hyperemia Eye Hyperemia Of Conjunctiva
Myofascial Pain Syndrome	Myofascial Pain Syndromes Myofascial Pain Dysfunction Syndrome Fibromyalgia
Causalgia	Complex Regional Pain Syndrome, Type Ii Complex Regional Pain Syndrome Type 2
Mononeuropathy	Mononeuropathies
Diabetic Polyneuropathy	Diabetes Mellitus With Polyneuropathy Polyneuropathy In Diabetes Diabetic Polyneuropathies Diabetic Neuropathy Nos
Nerve Compression Syndrome	Entrapment Neuropathies Compression Neuropathy Entrapment Neuropathy Peripheral Nerve Entrapment Syndrome Nerve Compression Syndromes Hereditary Liability To Pressure Palsies
Autonomic Nervous System Disease	Autonomic Nervous System Dysfunction Autonomic Nervous System Disorders Autonomic Nervous System Disorder Autonomic Nervous System Diseases Abnormality Of The Autonomic Nervous System
Neuroma
Acute Cystitis	Urinary Tract Infection Recurrent Urinary Tract Infection
Chronic Cystitis
Trigeminal Neuralgia	Tic Douloureux Trifacial Neuralgia Trifocal Neuralgia Neuralgia Of The Fifth Cranial Nerve Neuralgia Of 5th Cranial Nerve Infraorbital Neuralgia
Sick Building Syndrome
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Neurogenic Bladder	Neurogenic Dysfunction Of The Urinary Bladder Neurogenic Urinary Bladder Disorder Neuropathic Bladder Bladder Neurogenic Urinary Bladder, Neurogenic Neurogenic Urinary Bladder
Brachyolmia	Brachyrachia
Scapuloperoneal Spinal Muscular Atrophy	SPSMA Amyotrophy, Neurogenic Scapuloperoneal, New England Type Neurogenic Scapuloperoneal Amyotrophy, New England Type Scapuloperoneal Neuronopathy Spinal Muscular Atrophy, Scapuloperoneal Amyotrophy Neurogenic Scapuloperoneal New England Type Muscular Atrophy, Spinal Scapuloperoneal Form Of Spinal Muscular Atrophy
Specific Developmental Disorder
Acute Salpingo-Oophoritis	Acute Salpingitis And Oophoritis
Reflex Sympathetic Dystrophy	Algodystrophy Reflex Sympathetic Dystrophy Syndrome Complex Regional Pain Syndrome Type 1 Complex Regional Pain Syndromes Algodystrophic Syndrome
Paroxysmal Extreme Pain Disorder	PEPD Familial Rectal Pain Pexpd Submandibular, Ocular, And Rectal Pain With Flushing Pain, Submandibular, Ocular, And Rectal, With Flushing Rectal Pain, Familial Submandibular, Ocular And Rectal Pain With Flushing Familial Rectal Syndrome Frp Pain Disorder, Paroxysmal, Extreme
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Cannabis Abuse	Marijuana Abuse
Low Compliance Bladder	Overactive Bladder Hyperactivity Of Bladder Hypertonic Bladder Hypertonicity Of Bladder Low Bladder Compliance Oab - [Overactive Bladder]
Glossopharyngeal Neuralgia	Glossopharyngeal Nerve Diseases
Uvulitis	Acute Uvulitis
Erythromelalgia	Primary Erythromelalgia Erythermalgia Primary Erythermalgia Mitchell Disease Familial Erythromelalgia
Dental Pulp Disease	Dental Pulp Diseases Dental Pulp Disorder Disorder Of Pulp Of Tooth Pulp Disorder
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Metatropic Dysplasia	Metatropic Dwarfism MTD Metatropic Dysplasia Type 1 Metatropic Dysplasia, Nonlethal Dominant
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Uremic Neuropathy
Lennox-Gastaut Syndrome	Lennox Syndrome Encephalopathy Of Childhood Epileptic Encephalopathy Lennox-Gastaut Type Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves Lgs
Sensory Peripheral Neuropathy	Sensory Neuropathy Peripheral Sensory Neuropathy Hereditary Sensory And Autonomic Neuropathies
Viral Laryngitis
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Aspiration Pneumonia	Pneumonia, Aspiration Pneumonia Aspiration Aspiration Pneumonitis
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Vulvar Syringoma
Dravet Syndrome	Severe Myoclonic Epilepsy Of Infancy Severe Myoclonic Epilepsy In Infancy Smei Epileptic Encephalopathy, Early Infantile, 6 DRVT Developmental And Epileptic Encephalopathy 6a Dee6a Eiee6 Developmental And Epileptic Encephalopathy, 6 Dee6 Developmental And Epileptic Encephalopathy 6 Early Infantile Epileptic Encephalopathy 6 Myoclonic Epilepsy, Severe, Of Infancy Sme Severe Myoclonus Epilepsy Of Infancy Borderline Smei Smeb Smeb-M Smeb-O Smeb-Sw Smei-Borderland Smei-Borderland More Than One Feature Smei-Borderland-Myoclonic Seizures Smei-Borderland-Spike Wave Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures ICEGTC Infantile Severe Myoclonic Epilepsy Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Subungual Glomus Tumor	Subungual Glomus Tumour
Developmental And Epileptic Encephalopathy 24	DEE24 Epileptic Encephalopathy, Early Infantile, 24 Eiee24 Developmental And Epileptic Encephalopathy, 24 Early Infantile Epileptic Encephalopathy 24 Encephalopathy, Epileptic, Early Infantile, Type 24
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Type 1 Diabetes Mellitus 8	Diabetes Mellitus, Insulin-Dependent, 8 Iddm8 Insulin-Dependent Diabetes Mellitus 8 T1D8 Insulin-Dependent Diabetes Mellitus-8
Constipation
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-16413	Protokylol hydrochloride	Agonist	99.07%	Unkown
HY-A0191	Dexbrompheniramine	Antagonist	99.93%	Unkown
HY-124073	Dihydrocapsiate	Agonist	99.33%	Unkown

Clinical Phase

Bioactive Molecules (8)

Cat. No.	상품명	효과	Purity	Phase
HY-118785	MSP-3	Agonist	98.53%	Phase 2
HY-114017	Libvatrep	Antagonist	99.54%	Phase 2
HY-12914	V116517	Antagonist	/	Phase 2
HY-W517163	MK-2295	Antagonist	/	Phase 2
HY-19589	JTS-653	Antagonist	/	Phase 2
HY-N8377	Capsiate	Agonist	99.85%	Phase 1
HY-P10762	Ricorfotide vedotin	Ligand	98.45%	Phase 1
HY-10635	ABT-102	Antagonist	98.50%	Phase 1

Pre-clinical Phase

Bioactive Molecules (46)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-10863	Anandamide	Activator	≥99.0%	Unkown
HY-12245	SB-366791	Antagonist	99.29%	Unkown
HY-N0361	Dihydrocapsaicin	Agonist	99.93%	Unkown
HY-120691A	GSK205	Antagonist	99.47%	Unkown
HY-107436	LE135	Activator	99.0%	Unkown
HY-108448	N-Oleoyldopamine	Agonist	99.47%	Unkown
HY-101323	Olvanil	Agonist	≥99.0%	Unkown
HY-N8264	Moringin	Agonist	99.95%	Unkown
HY-132596A	Tivanisiran sodium	Inhibitor	96.85%	Unkown
HY-100129	JNJ-17203212	Antagonist	99.44%	Unkown
HY-N5084	Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside	Antagonist	98.92%	Unkown
HY-N0637A	(±)-Eriodictyol	Inhibitor	99.9%	Unkown
HY-136363	MDR-652	Agonist	98.08%	Unkown
HY-110018	N-Arachidonyldopamine	Activator	98.36%	Unkown
HY-144372	TRPV1 antagonist 3	Antagonist	99.30%	Unkown
HY-101389	(R)-Methanandamide	Agonist	99.61%	Unkown
HY-N7144A	Citronellyl acetate		98.0%	Unkown
HY-103333	Arvanil	Agonist	99.1%	Unkown
HY-120962	N-Arachidonoyl Taurine	Activator	99.3%	Unkown
HY-120294	Chrysin 6-C-glucoside 8-C-arabinoside	Inhibitor	98.55%	Unkown
HY-185011	AM9053	Activator	98.36%	Unkown
HY-103325	JTE-907	Activator	98.54%	Unkown
HY-P1175	L-R4W2	Antagonist	98.13%	Unkown
HY-172774	TRPV1 antagonist 10	Antagonist	98.54%	Unkown
HY-W014394	Vanillyl butyl ether	Agonist	99.75%	Unkown
HY-W790266	Polygodial pyridazine	Agonist	/	Unkown
HY-111218	TRPV1 antagonist 5	Antagonist	/	Unkown
HY-105324	GRC-6211	Antagonist	/	Unkown
HY-156959	Ovalicin	Inhibitor	/	Unkown
HY-120037	A 80426	Inhibitor	/	Unkown
HY-P1175A	L-R4W2 TFA	Antagonist	/	Unkown
HY-165459	KJM429	Modulator	/	Unkown
HY-184331	FAAH-IN-10	Antagonist	/	Unkown
HY-167160	AZ12099548	Antagonist	/	Unkown
HY-182517	AG1529	Antagonist	/	Unkown
HY-162908	TRPV1/CB2 agonist 1	Agonist	/	Unkown
HY-157766	FAAH/TRPV1 blocker-1	Inhibitor	/	Unkown
HY-P11022	TL-119	Inhibitor	/	Unkown
HY-106427	SA-13353	Agonist	/	Unkown
HY-115133	ABT-116	Antagonist	/	Unkown
HY-108459	6-Iodonordihydrocapsaicin	Antagonist	/	Unkown
HY-176063	TRPV1 antagonist 11	Antagonist	/	Unkown
HY-183857	DD-161515	Inhibitor	/	Unkown
HY-181463	20-Hydroxy-N-arachidonoyl taurine	Activator	/	Unkown
HY-N12639	β-Sanshool	Activator	/	Unkown
HY-N11077	4,5-Di-O-caffeoylquinic acid	Activator	98%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRPV1	VGNC	VGNC:47882
Macaca mulatta	TRPV1	VGNC	VGNC:78777
Mus musculus	TRPV1	MGD	MGI:1341787
Bos taurus	TRPV1	VGNC	VGNC:36397
Rattus norvegicus	TRPV1	RGD	RGD:628841
Felis catus	TRPV1	VGNC	VGNC:66595
Others	TRPV1	NCBI