Jak1 - Janus kinase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84598

About Jak1

Primary_assembly 5: 115,780,248-115,888,926 reverse strand.mRatBN7.2:CM026978.1

This gene has 4 transcripts (splice variants), 238 orthologues, 32 paralogues and is associated with 29 phenotypes. Biased expression in Thymus (RPKM 855.), Spleen (RPKM 452.2) and 9 other tissues.

Summary

Enables CCR5 Chemokine Receptor binding activity and growth hormone receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of homotypic cell-cell adhesion; and positive regulation of sprouting angiogenesis. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to cytokine stimulus; and positive regulation of receptor signaling pathway via STAT. Predicted to be located in cytoplasm and nucleus. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; colorectal cancer; hepatocellular carcinoma; ovarian cancer; and pancreatic adenocarcinoma. Orthologous to human JAK1 (Janus kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Jak1 Products (2)

mRNA Protein Name
NM_053466.1 NP_445918.1 tyrosine-protein kinase JAK1
NM_053466.1 NP_445918.1 tyrosine-protein kinase JAK1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables CCR5 chemokine receptor binding IPI
IPI: Inferred from physical interaction
14674010 RGD
enables growth hormone receptor binding IPI
IPI: Inferred from physical interaction
11244571 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Jak1 Protein Structure

FERM_F1

FERM_F1: cl39717 (51 - 128)

FERM_F2

FERM_F2: pfam18377 (146 - 276)

FERM_C_JAK1

FERM_C_JAK1: cd13332 (281 - 425)

SH2_Jak1

SH2_Jak1: cd10378 (425 - 525)

PTK_Jak1_rpt1

PTK_Jak1_rpt1: cd05077 (581 - 844)

PTKc_Jak1_rpt2

PTKc_Jak1_rpt2: cd05079 (868 - 1151)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1153 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase JAK1

  • Janus protein tyrosine kinase 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50856 Ruxolitinib Inhibitor 99.99% Yes
HY-40354 Tofacitinib Inhibitor 99.99% Yes
HY-19569 Upadacitinib Inhibitor 99.98% Yes
HY-15315 Baricitinib Inhibitor 99.97% Yes
HY-117287 Deucravacitinib Inhibitor 99.93% Unkown
HY-50858 Ruxolitinib phosphate Inhibitor 99.92% Yes
HY-40354A Tofacitinib citrate Inhibitor 99.94% Yes
HY-16379 Pacritinib Inhibitor 99.93% Yes
HY-10961 Momelotinib Inhibitor 98.93% Unkown
HY-107429 Abrocitinib Inhibitor 99.26% Unkown
HY-18300 Filgotinib Inhibitor 99.77% Yes
HY-19568 Peficitinib Inhibitor 99.43% Yes
HY-15315A Baricitinib phosphate Inhibitor 99.97% Yes
HY-109053 Delgocitinib Inhibitor 99.61% Unkown
HY-13577 Oclacitinib Inhibitor 99.03% Unkown
HY-13577A Oclacitinib monomaleate Inhibitor 99.87% Unkown
HY-50856S Deuruxolitinib Inhibitor 99.18% Unkown
HY-18300A Filgotinib maleate Inhibitor 99.88% Yes
HY-50859 Ruxolitinib sulfate Inhibitor / Unkown
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / Unkown
HY-19568A Peficitinib hydrobromide Inhibitor / Unkown
HY-16379A Pacritinib hydrochloride Inhibitor / Unkown
HY-19568B Peficitinib hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-112724 Ivarmacitinib Inhibitor 99.62% Phase 4
HY-16997 Itacitinib Inhibitor 99.97% Phase 3
HY-107361 Golidocitinib Inhibitor 99.54% Phase 3
HY-15999 Cerdulatinib Inhibitor 99.06% Phase 3
HY-12469 Decernotinib Inhibitor 99.91% Phase 3
HY-112708A Brepocitinib P-Tosylate Inhibitor 99.99% Phase 3
HY-174905 Quecitinib Inhibitor 99.35% Phase 3
HY-130247A Flonoltinib TFA Inhibitor 98.94% Phase 3
HY-10193 AZD-1480 Inhibitor 99.74% Phase 2
HY-126294 Londamocitinib Inhibitor 99.79% Phase 2
HY-15270 BMS-911543 Inhibitor 98.23% Phase 2
HY-156961 Cadefrecitinib Inhibitor 99.81% Phase 2
HY-16755 Solcitinib Inhibitor 99.51% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.33% Phase 2
HY-159536 Frevecitinib Inhibitor 99.42% Phase 2
HY-101024 PF-06263276 Inhibitor ≥99.0% Phase 1
HY-179715 PROTAC JAK1/2 degrader-1 Degrader 99.47% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99244 Fezakinumab Modulator 99.9% Phase 2

Pre-clinical Phase

Bioactive Molecules (95)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W063968 RO8191 Activator ≥99.0% Unkown
HY-112708 Brepocitinib Inhibitor 99.95% Yes
HY-14435 Pyridone 6 Inhibitor 98.20% Unkown
HY-130247 Flonoltinib Inhibitor 99.48% Unkown
HY-145551 Atinvicitinib Inhibitor 98.62% Unkown
HY-10962 Momelotinib sulfate Inhibitor 98.63% Yes
HY-151385 VVD-118313 Inhibitor 99.47% Unkown
HY-14722 NVP-BSK805 Inhibitor 99.30% Unkown
HY-19631A Ilginatinib Inhibitor 99.81% Unkown
HY-100895 SAR-20347 Inhibitor 97.27% Unkown
HY-108264 TCS 21311 Inhibitor 99.49% Unkown
HY-162608 PROTAC JAK1 degrader 1 Degrader 99.97% Unkown
HY-151262 JAK-IN-23 Inhibitor 98.88% Unkown
HY-12589 ZM39923 hydrochloride Inhibitor 99.84% Unkown
HY-12538 Graveoline Inhibitor 99.93% Unkown
HY-15814 HG-7-85-01 Inhibitor 98.14% Unkown
HY-153701S Envudeucitinibum Inhibitor 99.56% Unkown
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% Unkown
HY-19544 JAK3-IN-1 Inhibitor 99.31% Unkown
HY-15999A Cerdulatinib hydrochloride Inhibitor 98.96% Yes
HY-131906 JAK2-IN-7 Inhibitor 98.31% Unkown
HY-150720 TYK2-IN-12 Inhibitor 98.81% Unkown
HY-19631B Ilginatinib hydrochloride Inhibitor 98.92% Unkown
HY-151385A (R,R)-VVD-118313 Inhibitor 99.34% Unkown
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 99.80% Unkown
HY-153440 Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate Inhibitor 98.01% Unkown
HY-W394903 GS-829845 Inhibitor 99.19% Unkown
HY-139423 JAK1-IN-8 Inhibitor 95.0% Unkown
HY-143444 JAK-IN-20 Inhibitor 99.63% Unkown
HY-162248 JAK1/2-IN-1 Inhibitor 98.36% Unkown
HY-111750 JAK-IN-3 Inhibitor 98.92% Unkown
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% Unkown
HY-N7653 Azaleatin Inhibitor 98.86% Unkown
HY-13961 GLPG0634 analog Inhibitor 98.07% Unkown
HY-179716 JAK1/2 ligand 1 Ligand 99.91% Unkown
HY-100849 JAK 3i Inhibitor 99.81% Unkown
HY-152080 Blovacitinib Inhibitor 99.71% Unkown
HY-116505 JAK1-IN-4 Inhibitor 99.26% Unkown
HY-13450 ZM 449829 Inhibitor 99.73% Unkown
HY-16997A Itacitinib adipate Inhibitor 99.18% Yes
HY-148060 JAK-IN-21 Inhibitor 99.72% Unkown
HY-161618 MJ04 Inhibitor 98.08% Unkown
HY-170772 Dual Cathepsin L/JAK-IN-1 Inhibitor 98.47% Unkown
HY-123115 Leucrose 98.53% Unkown
HY-181929 RAI-20 Inhibitor 98.66% Unkown
HY-182359 YYSW001 Inhibitor / Unkown
HY-14722C NVP-BSK805 trihydrochloride Inhibitor / Unkown
HY-147975 JAK3-IN-12 Inhibitor / Unkown
HY-170723 JAK-IN-39 Inhibitor / Unkown
HY-188034 JAK-IN-44 Inhibitor / Unkown
HY-154994 JAK-IN-30 Inhibitor / Unkown
HY-168339 Tyk2-IN-22 Inhibitor / Unkown
HY-143885 JAK1/TYK2-IN-3 Inhibitor / Unkown
HY-175684 JAK2-IN-14 Inhibitor / Unkown
HY-187103 JAK1-IN-22 Inhibitor / Unkown
HY-161259 JAK-IN-36 Inhibitor / Unkown
HY-139649 Ten01 Inhibitor / Unkown
HY-184592 JAK1-IN-21 Inhibitor / Unkown
HY-152080A (R)-Blovacitinib Inhibitor / Unkown
HY-178282 JAK1-IN-19 Inhibitor / Unkown
HY-174430 WWQ-131 Inhibitor / Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-144440 JAK1-IN-9 Inhibitor / Unkown
HY-N14094 Tubulosine Inhibitor / Unkown
HY-187502 Jak1 RIMTAC-1 Degrader / Unkown
HY-175009 MRC-G-001 Inhibitor / Unkown
HY-175983 JAK1/TYK2-IN-5 Inhibitor / Unkown
HY-168893 K882 Inhibitor / Unkown
HY-170977 JAK1/STAT3-IN-1 Inhibitor / Unkown
HY-108342 PF-00956980 Inhibitor / Unkown
HY-W635076 oJak-989 Inhibitor / Unkown
HY-149296 JAK1-IN-12 Inhibitor / Unkown
HY-153566 JAK1-IN-10 Inhibitor / Unkown
HY-146727 JAK3-IN-11 Inhibitor / Unkown
HY-W064657 Momelotinib dihydrochloride Inhibitor 99.56% Unkown
HY-177006 JAK1/2-IN-2 Inhibitor / Unkown
HY-164111 JNK-IN-17 Inhibitor / Unkown
HY-180274 JAK1/2-IN-3 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-174999 JAK3-IN-18 Inhibitor / Unkown
HY-181872 JAK1-IN-20 Inhibitor / Unkown
HY-181528 JAK1/CDK7-IN-1 Inhibitor / Unkown
HY-176793 Embricitinib Inhibitor / Unkown
HY-161139 JAK1-IN-14 Inhibitor / Unkown
HY-168269 Tyk2-IN-20 Inhibitor / Unkown
HY-10963 Momelotinib mesylate Inhibitor / Unkown
HY-162862 JAK-IN-38 Inducer / Unkown
HY-183519 AH057 Inhibitor / Unkown
HY-185924 Domusiran Inhibitor / Unkown
HY-157121 JAK-IN-34 Inhibitor / Unkown
HY-123187 AS2553627 Inhibitor / Unkown
HY-162862 JAK-IN-38 Inhibitor / Unkown
HY-123939 JAK1/3-IN-1 Inhibitor / Unkown
HY-130247B Flonoltinib monomaleate Inhibitor / Unkown
HY-12589A ZM39923 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jak1 NCBI NCBI:3716