Cat. No.: HY-B0130

Perindopril

(Synonyms: S-9490)

8 Cited Publications

Customer Review

Based on 8 publication(s) in Google Scholar

Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure.

For research use only. We do not sell to patients.

Purity: 99.85%
CAS No.: 82834-16-0
Formula: C₁₉H₃₂N₂O₅
Molecular Weight:368.47

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Perindopril Chemical Structure

CAS No.: 82834-16-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

STAT3

SIRT3

All NF-κB Isoforms :

All STAT Isoforms :

All Sirtuin Isoforms :

In Vitro

Perindopril erbumine (1 μM, 24 h) ameliorats gliosis and blunts decrease induced by LPS (HY-D1056) in AT2R expression in Rat astrocytoma cell line (C6) and murine microglial cell line (BV2)^[1].
Perindopril erbumine (1 μM, 24 h) prevents IκBα degradation, NFкB nuclear translocation and STAT3 activation induced by LPS (HY-D1056) in C6 and BV2^[1].
Perindopril erbumine (1 μM, 24 h) ameliorats the imbalance in the release of inflammatory cytokine and blunts the aberrant ROS production and the nitrite release induced by LPS (HY-D1056) in C6 and BV2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Perindopril erbumine (0.1 mg/kg, Oral gavage, once a day for five consecutive days) prevents LPS-induced neuroinflammation in rats^[1].
Perindopril erbumine (0.42 mg/kg, Oral, once a day for 4 weeks) with Huangqi-Danshen decoction (HDD) (4.7 g/kg, Oral, once a day for 4 weeks) attenuates adenine-induced Chronic kidney disease (CKD) in rats^[2].
Perindopril erbumine (0.4-1.5 mg/kg, Oral, once a day for 4-24 weeks) has a persistent effect on blood pressure in spontaneously hypertensive rats (SHR)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LPS-induced neuroinflammation rat model^[1]
Dosage:

0.1 mg/kg
Administration:

Oral gavage (p.o.)
Result:

Abolished the LPS-induced astroglial and microglial activation.
Attenuated LPS-induced TNF-α production.
Prevented LPS-induced nuclear translocation of NF-кB.
Prevented the AT1R up-regulation and the LPS-induced decrease in the expression of PP2A.

Animal Model:

Adenine-induced chronic kidney disease rats^[2]
Dosage:

0.42 mg/kg
Administration:

Oral
Result:

Obviously reduced serum creatinine (Scr) and blood urea nitrogen (BUN) levels.
Displayed a marked reduction of tubulointerstitial fibrosis.
Exhibited more inhibitory effect on Col-IV expression and a exceed effect of raising OPA-1 expression.
Significantly increased Sirtuin3 expression.
Prevented mitochondrial fragmentation.

Chemical Information

CAS No. 82834-16-0
Appearance Solid
Molecular Weight 368.47
Formula C₁₉H₃₂N₂O₅
Color Off-white to light yellow
SMILES

O=C([C@H]1N(C([C@@H](N[C@H](C(OCC)=O)CCC)C)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O
Synonyms

S-9490
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (8)

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Journal Impact Factor

J Biomed Sci

Immune cell uptake of glycinated nanoparticles conjugated to anti-fibrotic peptides enables their prolonged activity and oral administration. [Abstract]

2025 Dec 12;32(1):104. PMID: 41382190
Phytomedicine

Huangqi-Danshen decoction improves heart failure by regulating pericardial adipose tissue derived extracellular vesicular miR-27a-3p to activate AMPKα2 mediated mitophagy. [Abstract]

2024 Oct 28:135:156187. PMID: 39488874
Br J Pharmacol

Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt-induced hypertension. [Abstract]

2021 Mar;178(5):1164-1181. PMID: 33450051
Biomed Pharmacother

The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy. [Abstract]

2023 Apr:160:114370. PMID: 36753958
Stem Cell Res Ther

The renoprotective efficacy and safety of genetically-engineered human bone marrow-derived mesenchymal stromal cells expressing anti-fibrotic cargo. [Abstract]

2024 Oct 23;15(1):375. PMID: 39443975
Life Sci

Serelaxin has greater anti-fibrotic potential than perindopril but maintains its anti-fibrotic efficacy in the presence of perindopril in normotensive mouse models of heart disease. [Abstract]

2026 Aug 15:399:124472. PMID: 42176886
Biosci Rep

Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects. [Abstract]

2021 Oct 29;41(10):BSR20211598. PMID: 34633033
Evid Based Complement Alternat Med

Combination of Perindopril Erbumine and Huangqi-Danshen Decoction Protects Against Chronic Kidney Disease via Sirtuin3/Mitochondrial Dynamics Pathway. [Abstract]

2022 May 21;2022:5812105. PMID: 35677375

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (271.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (271.39 mM; ultrasonic and warming and heat to 80°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7139 mL

13.5696 mL

27.1392 mL

5 mM

0.5428 mL

2.7139 mL

5.4279 mL

10 mM

0.2714 mL

1.3570 mL

2.7139 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bhat S A, et al. Angiotensin receptor blockade modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation better than angiotensin-converting enzyme inhibition [J]. Molecular neurobiology, 2016, 53: 6950-6967. [Content Brief]

[2]. Wei X, et al. Combination of perindopril erbumine and huangqi-danshen decoction protects against chronic kidney disease via sirtuin3/mitochondrial dynamics pathway [J]. Evidence-Based Complementary and Alternative Medicine, 2022, 2022. [Content Brief]

[3]. Afonso T, et al. Pharmacodynamic evaluation of 4 angiotensin‐converting enzyme inhibitors in healthy adult horses [J]. Journal of veterinary internal medicine, 2013, 27(5): 1185-1192. [Content Brief]

[4]. Thybo N K, et al. Dose-dependent effects of perindopril on blood pressure and small-artery structure [J]. Hypertension, 1994, 23(5): 659-666. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	2.7139 mL	13.5696 mL	27.1393 mL	67.8481 mL
	5 mM	0.5428 mL	2.7139 mL	5.4279 mL	13.5696 mL
	10 mM	0.2714 mL	1.3570 mL	2.7139 mL	6.7848 mL
	15 mM	0.1809 mL	0.9046 mL	1.8093 mL	4.5232 mL
	20 mM	0.1357 mL	0.6785 mL	1.3570 mL	3.3924 mL
	25 mM	0.1086 mL	0.5428 mL	1.0856 mL	2.7139 mL
	30 mM	0.0905 mL	0.4523 mL	0.9046 mL	2.2616 mL
	40 mM	0.0678 mL	0.3392 mL	0.6785 mL	1.6962 mL
	50 mM	0.0543 mL	0.2714 mL	0.5428 mL	1.3570 mL
	60 mM	0.0452 mL	0.2262 mL	0.4523 mL	1.1308 mL
	80 mM	0.0339 mL	0.1696 mL	0.3392 mL	0.8481 mL
	100 mM	0.0271 mL	0.1357 mL	0.2714 mL	0.6785 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Perindopril

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

FDA-Approved Drug Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

NMPA-Approved Drug Library

Pyroptosis Compound Library

Orally Active Compound Library

Glutamine Metabolism Compound Library

FDA Approved & Pharmacopeial Drug Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Rare Diseases Drug Library

Protein-protein Interaction Inhibitor Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Pain-Related Compound Library

Off-patent Drug Library

Antihypertensive Compound Library

Metabolic Enzyme Compound Library

Protease Inhibitor Library

Membrane Protein-targeted Compound Library

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MCE Bioactive Compound Library

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FDA-Approved Drug Library Mini

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Nephrotoxicity Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) Perindopril

All NF-κB Isoforms

All STAT Isoforms

All Sirtuin Isoforms

Biological Activity

Chemical Information

Publications (8)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Perindopril Related Classifications

HY-B0130 Related Classifications