LO-3-63
Based on 1 Customer Validation
LO-3-63, a Ribociclib (HY-15777) analog bearing a truncated fumaramide handle, is a PROTAC-like CDK4/6 degrader. LO-3-63 induces CUL4DCAF16-dependent degradation of CDK4/6 in cells.
For research use only. We do not sell to patients.
- Purity: 98.16%
- Formula: C32H35ClN10O3
- Molecular Weight:643.14
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
LO-3-63 (1-10 μM, 12-24 h) leads to the proteasome mediated degradation of CDK4/6 in HEK293T cells, an effect that can be attenuated in DCAF16 KO cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T cells (WT, DCAF16 KO)
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Concentration:1, 5, 10 μM
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Incubation Time:12, 24 h
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Result:Degraded CDK4/6 in HEK293T cells (WT), an effect that can be attenuated in DCAF16 KO cells.
Chemical Information
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Appearance Solid
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Molecular Weight 643.14
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Formula C32H35ClN10O3
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Color Light yellow to yellow
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SMILES
O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(C(/C=C/C(NC5=CC(Cl)=CN=C5)=O)=O)CC4)C=C3)N=C2N1C6CCCC6)N(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (155.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5549 mL | 7.7744 mL | 15.5487 mL | 38.8718 mL |
| 5 mM | 0.3110 mL | 1.5549 mL | 3.1097 mL | 7.7744 mL | |
| 10 mM | 0.1555 mL | 0.7774 mL | 1.5549 mL | 3.8872 mL | |
| 15 mM | 0.1037 mL | 0.5183 mL | 1.0366 mL | 2.5915 mL | |
| 20 mM | 0.0777 mL | 0.3887 mL | 0.7774 mL | 1.9436 mL | |
| 25 mM | 0.0622 mL | 0.3110 mL | 0.6219 mL | 1.5549 mL | |
| 30 mM | 0.0518 mL | 0.2591 mL | 0.5183 mL | 1.2957 mL | |
| 40 mM | 0.0389 mL | 0.1944 mL | 0.3887 mL | 0.9718 mL | |
| 50 mM | 0.0311 mL | 0.1555 mL | 0.3110 mL | 0.7774 mL | |
| 60 mM | 0.0259 mL | 0.1296 mL | 0.2591 mL | 0.6479 mL | |
| 80 mM | 0.0194 mL | 0.0972 mL | 0.1944 mL | 0.4859 mL | |
| 100 mM | 0.0155 mL | 0.0777 mL | 0.1555 mL | 0.3887 mL |
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