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Cat. No.: HY-184487

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Anticancer agent 331

Anticancer agent 331 is an anticancer agent with favorable cell permeability and limited blood-brain barrier penetration. Anticancer agent 331 forms stable long-acting complexes with TNF-α, PI3K p110α, AKT1 and mTOR, and exerts cytotoxic effects on cancer cells. Anticancer agent 331 can be used in the research of colorectal cancer.

For research use only. We do not sell to patients.

Formula: C₂₉H₂₀ClN₅O₃S₂
Molecular Weight:586.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 331 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

Akt1

p110α

All TNF Receptor Isoforms :

All PI3K Isoforms :

All Akt Isoforms :

All mTOR Isoforms :

In Vitro

Anti-cancerOthers

Anti-cancer

Anticancer agent 331 (compound 5d) (4.10-49.08 µM) potently inhibits human colorectal carcinoma HCT-116 cell viability with an IC₅₀ of 4.10 µM and exhibits high selectivity for cancer cells over human dermal fibroblast CCD-1076Sk cells, with a selectivity index of 12.0^[1].

Others

Anticancer agent 331 has a viable pharmacokinetic profile, with acceptable intestinal permeability, good predicted oral absorption, limited blood-brain barrier penetration, and two Lipinski rule of five violations typical of potent kinase inhibitors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 586.08
Formula C₂₉H₂₀ClN₅O₃S₂
SMILES

O=S(C1=CN=CC=C1)(N2C=C(C3=CC=CC=C32)/C=N/N=C4SC=C(N\4C5=CC=CC(Cl)=C5)C6=CC=C(C=C6)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Batool Z, et al. Synthesis, biological evaluation and detailed computational studies of N-sulfonyl indole-based dihydrothiazoles against colorectal carcinoma. Scientific reports. 2026 Jun 10;16(1):18334. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Anticancer agent 331

All TNF Receptor Isoforms

All PI3K Isoforms

All Akt Isoforms

All mTOR Isoforms