3-Methylxanthine
Based on 1 Customer Validation
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.45%
- CAS 番号: 1076-22-8
- 分子式: C6H6N4O2
- 分子量:166.14
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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GMP 920 μM (IC50) |
化学情報
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CAS 番号 1076-22-8
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性状 Solid
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分子量 166.14
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分子式 C6H6N4O2
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Color White to khaki
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SMILES
O=C1N(C)C2=C(N=CN2)C(N1)=O
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別名
3-メチルキサンチン
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
1M NaOH : 50 mg/mL (300.95 mM; ultrasonic and adjust pH to 11 with 1M NaOH)
DMSO : 2 mg/mL (12.04 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Tanaka H, et al. Inhibition of cyclic GMP phosphodiesterase by xanthine derivatives relaxes guinea-pig trachealis smooth muscle. Clin Exp Pharmacol Physiol. 1991 Mar;18(3):163-8. [Content Brief]
[2]. Yamamoto K, et al. Neurotoxic convulsions induced by theophylline and its metabolites in mice. Biol Pharm Bull. 1996 Jun;19(6):869-72. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 1M NaOH | 1 mM | 6.0190 mL | 30.0951 mL | 60.1902 mL | 150.4755 mL |
| 5 mM | 1.2038 mL | 6.0190 mL | 12.0380 mL | 30.0951 mL | |
| 10 mM | 0.6019 mL | 3.0095 mL | 6.0190 mL | 15.0476 mL | |
| 1M NaOH | 15 mM | 0.4013 mL | 2.0063 mL | 4.0127 mL | 10.0317 mL |
| 20 mM | 0.3010 mL | 1.5048 mL | 3.0095 mL | 7.5238 mL | |
| 25 mM | 0.2408 mL | 1.2038 mL | 2.4076 mL | 6.0190 mL | |
| 30 mM | 0.2006 mL | 1.0032 mL | 2.0063 mL | 5.0159 mL | |
| 40 mM | 0.1505 mL | 0.7524 mL | 1.5048 mL | 3.7619 mL | |
| 50 mM | 0.1204 mL | 0.6019 mL | 1.2038 mL | 3.0095 mL | |
| 60 mM | 0.1003 mL | 0.5016 mL | 1.0032 mL | 2.5079 mL | |
| 80 mM | 0.0752 mL | 0.3762 mL | 0.7524 mL | 1.8809 mL | |
| 100 mM | 0.0602 mL | 0.3010 mL | 0.6019 mL | 1.5048 mL |
3-Methylxanthine 関連分類
HY-50723 関連分類
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