BSF2
BSF2 is a anti-Leishmania agent. BSF2 modulates gene expression linked to ubiquitination, chromatin remodeling, and peroxisomal membrane transport pathways in Leishmania braziliensis. BSF2 downregulates TNF, IL-17, NF-κB, and Toll-like receptor pathways in Leishmania-infected macrophages. BSF2 exerts leishmanicidal activity against intracellular Leishmania braziliensis amastigotes. BSF2 can be used for the research of american tegumentary leishmaniasis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 179118-06-0
- 分子式: C20H20N4O
- 分子量:332.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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IL-17 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
74.04 μM
Compound: 27d
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Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 24 hrs by Alamar blue assay
Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 24 hrs by Alamar blue assay
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[PMID: 28038325] |
BSF2 (1-80 μM; 48 h) exhibits a CC50 of 11.11 μM against RAW 264.7 mouse macrophages, with 81.52% macrophage viability remaining at a 10 μM treatment concentration[1].
BSF2 (1-80 μM; 48 h) potently inhibits intracellular Leishmania braziliensis in RAW 264.7 macrophages with an EC50 of 0.64 μM and a high selectivity index of 17.36, reducing parasite viability to 5.73% at a 10 μM treatment concentration[1].
BSF2 (0.16 μM; 48 h) alters parasite gene expression in ubiquitination, chromatin remodeling, and peroxisomal transport pathways, while downregulating host inflammatory pathways including TNF, IL-17, NF-κB, and Toll-like receptor signaling in Leishmania braziliensis-infected RAW 264.7 macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 mouse macrophages
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Concentration:1-80 μM; 10 μM
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Incubation Time:48 h
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Result:Resulted in 81.52% macrophage viability at 10 μM.
Determined a CC50 of 11.11 μM.
化学情報
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CAS 番号 179118-06-0
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分子量 332.40
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分子式 C20H20N4O
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SMILES
CC1=C(OC(C2=CC=C(C=C2)C(N)=N)=C1C)C3=CC=C(C=C3)C(N)=N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BSF2 関連分類
HY-183008 関連分類
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- BSF2
- 179118-06-0
- BSF 2
- BSF-2
- Parasite
- TNF Receptor
- Interleukin Related
- NF-κB
- Toll-like Receptor (TLR)
- Leishmania braziliensis
- peroxisomal membrane transport pathways
- chromatin remodeling
- IL-17
- american tegumentary leishmaniasis
- TNF
- ubiquitination
- RAW 264.7 mouse macrophages
- Toll-like receptor pathways
- Inhibitor
- inhibitor
- inhibit