KT5823
Based on 13 publication(s) in Google Scholar
KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively. KT5823 is a Staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- CAS 番号: 126643-37-6
- 分子式: C29H25N3O5
- 分子量:495.53
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 KT5823
More- Adv Mater. 2025 Dec 24:e16181. [Abstract]
- Mater Today Bio. 2024 Aug 10:28:101180. [Abstract]
- Cell Death Dis. 2023 Oct 16;14(10):682. [Abstract]
- World J Gastroenterol. 2025 Dec 14;31(46):111631. [Abstract]
- Biol Direct. 2025 Nov 27;20(1):113. [Abstract]
- Transl Stroke Res. 2025 Jun;16(3):868-881. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Jun;1871(5):167786. [Abstract]
- Drug Dev Res. 2024 May;85(3):e22192. [Abstract]
- J Neurochem. 2025 May;169(5):e70077. [Abstract]
- J Biol Chem. 2026 Jan 23;302(3):111202. [Abstract]
- J Virol. 2026 Feb 17;100(2):e0165625. [Abstract]
- Microbiol Spectr. 2024 Apr 2;12(4):e0322023. [Abstract]
- Res Sq. 2024 Jul 15.
Antibiotic アイソフォーム固有の製品をすべて表示
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生物活性
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PKA 10 μM (Ki) |
PKC 4 μM (Ki) |
KT5823 (15 μM, 18 h) arrests HSF55 cells in the G0 or G1 phase of the cell cycle[3].
KT5823 (100 nM and 1 mM, 24 h) causes dose-dependent increases in apoptotic DNA fragmentation in unstressed HRE-H9 cells [3].
KT5823 (0.2-200 μM, 30 min) enhances 8-pCPT-cGMP (HY-137016)-induced VASP phosphorylation, but not inhibits the activation of PKA by Forskolin (HY-15371) in human platelets[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human platelets
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Concentration:0.2-200 μM
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Incubation Time:30 min
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Result:Enhanced 8-pCPT-cGMP-induced VASP phosphorylation in human platelets.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Aβ1-42-treated mice[4]
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Dosage:2 nmol
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Administration:i.c.v., a single dose for 14 days
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Result:Significantly prevented the effects of Bay 60-7550 on step-down latency both 1 and 3 h after the training session in the Aβ1-42-treated mice.
化学情報
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CAS 番号 126643-37-6
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性状 Solid
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分子量 495.53
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分子式 C29H25N3O5
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Color White to off-white
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SMILES
C[C@@]([C@@]1(OC)C(OC)=O)(O[C@](N2C3=C4C=CC=C3)([H])C1)N5C(C2=C4C6=C7CN(C)C6=O)=C7C8=C5C=CC=C8
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (13)
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Journal Impact Factor
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Most Recent
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Adv Mater
A Dual-Action Nucleoside-Based Supramolecular Hydrogel Combats Periodontitis by Disrupting the Bacteria-Osteoclast Cascade. [Abstract]2025 Dec 24:e16181. PMID: 41441772 -
Mater Today Bio
A photothermal responsive system accelerating nitric oxide release to enhance bone repair by promoting osteogenesis and angiogenesis. [Abstract]2024 Aug 10:28:101180. PMID: 39221216 -
Cell Death Dis
Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress. [Abstract]2023 Oct 16;14(10):682. PMID: 37845207 -
World J Gastroenterol
IGF2BP3 binds to FBXO32 to activate the cyclic guanosine monophosphate-protein kinase G pathway, promoting gastric cancer progression. [Abstract]2025 Dec 14;31(46):111631. PMID: 41479643 -
Biol Direct
NAMPT modulates muscle fiber type transition in PAD myopathy via the cGMP-PKG signaling pathway. [Abstract]2025 Nov 27;20(1):113. PMID: 41310770 -
Transl Stroke Res
HDAC9 Deficiency Upregulates cGMP-dependent Kinase II to Mitigate Neuronal Apoptosis in Ischemic Stroke. [Abstract]2025 Jun;16(3):868-881. PMID: 38940872 -
Biochim Biophys Acta Mol Basis Dis
Silencing RGS7 attenuates atrial fibrillation progression by activating the cGMP-PKG signaling pathway. [Abstract]2025 Jun;1871(5):167786. PMID: 40086518 -
Drug Dev Res
Anti-NSCLC role of SCN4B by negative regulation of the cGMP-PKG pathway: Integrated utilization of bioinformatics analysis and in vitro assay validation. [Abstract]2024 May;85(3):e22192. PMID: 38678552 -
J Neurochem
PKG-Mediated Phosphorylation of TOP2A Activates HDAC to Drive Photoreceptor Cell Death in rd1 Mouse Inherited Retinal Degeneration. [Abstract]2025 May;169(5):e70077. PMID: 40320856 -
J Biol Chem
Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl- currents in the early distal convoluted tubule of the mouse kidney. [Abstract]2026 Jan 23;302(3):111202. PMID: 41581878 -
J Virol
Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity. [Abstract]2026 Feb 17;100(2):e0165625. PMID: 41489372 -
Microbiol Spectr
Heme oxygenase-1 is an equid alphaherpesvirus 8 replication restriction host protein and suppresses viral replication via the PKCβ/ERK1/ERK2 and NO/cGMP/PKG pathway. [Abstract]2024 Apr 2;12(4):e0322023. PMID: 38441979 -
溶剤 & 溶解度
DMSO : ≥ 20 mg/mL (40.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (285 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gadbois DM, et al. Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30. [Content Brief]
[2]. Wyatt TA, et al. KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin. Res Commun Chem Pathol Pharmacol. 1991 Oct;74(1):3-14. [Content Brief]
[3]. Chan SL, et al. Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod. 2003 Dec;9(12):775-83. [Content Brief]
[4]. Ruan L, et al. Phosphodiesterase-2 Inhibitor Bay 60-7550 Ameliorates Aβ-Induced Cognitive and Memory Impairment via Regulation of the HPA Axis. Front Cell Neurosci. 2019 Oct 2;13:432. [Content Brief]
[5]. Burkhardt M, et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem. 2000 Oct 27;275(43):33536-41. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0180 mL | 10.0902 mL | 20.1804 mL | 50.4510 mL |
| 5 mM | 0.4036 mL | 2.0180 mL | 4.0361 mL | 10.0902 mL | |
| 10 mM | 0.2018 mL | 1.0090 mL | 2.0180 mL | 5.0451 mL | |
| 15 mM | 0.1345 mL | 0.6727 mL | 1.3454 mL | 3.3634 mL | |
| 20 mM | 0.1009 mL | 0.5045 mL | 1.0090 mL | 2.5226 mL | |
| 25 mM | 0.0807 mL | 0.4036 mL | 0.8072 mL | 2.0180 mL | |
| 30 mM | 0.0673 mL | 0.3363 mL | 0.6727 mL | 1.6817 mL | |
| 40 mM | 0.0505 mL | 0.2523 mL | 0.5045 mL | 1.2613 mL |
KT5823 関連分類
HY-N6791 関連分類
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