LO-3-63
Based on 1 Customer Validation
LO-3-63 is a CDK4/CDK6 degrader. LO-3-63 induces proteasome-dependent degradation of CDK4/6 via CUL4DCAF16-dependent interaction.
(Pink: CDK4 and CDK6 ligand (HY-15777); Blue: CUL4DCAF16 E3 ligase ligand; Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.16%
- 分子式: C32H35ClN10O3
- 分子量:643.14
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
CDK4 |
CUL4DCAF16 |
CDK6 |
体外実験
LO-3-63 (1-10 μM; 12-24 h) induces robust, CUL4DCAF16-dependent degradation of CDK4 and CDK6 in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T cells, CUL4DCAF16 knockout HEK293T cells
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Concentration:1-10 μM (24 h incubation); 1-10 μM (12 h incubation)
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Incubation Time:24 h (1, 5, 10 μM); 12 h (1, 5, 10 μM)
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Result:Induced robust degradation of CDK4 and CDK6 in HEK293T cells at 1, 5, and 10 μM for 24 h.
Attenuated degradation of CDK4 and CDK6 in CUL4DCAF16 knockout HEK293T cells after 12 h of treatment with 1, 5, and 10 μM.
化学情報
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性状 Solid
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分子量 643.14
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分子式 C32H35ClN10O3
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Color Light yellow to yellow
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SMILES
O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(C(/C=C/C(NC5=CC(Cl)=CN=C5)=O)=O)CC4)C=C3)N=C2N1C6CCCC6)N(C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (155.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5549 mL | 7.7744 mL | 15.5487 mL | 38.8718 mL |
| 5 mM | 0.3110 mL | 1.5549 mL | 3.1097 mL | 7.7744 mL | |
| 10 mM | 0.1555 mL | 0.7774 mL | 1.5549 mL | 3.8872 mL | |
| 15 mM | 0.1037 mL | 0.5183 mL | 1.0366 mL | 2.5915 mL | |
| 20 mM | 0.0777 mL | 0.3887 mL | 0.7774 mL | 1.9436 mL | |
| 25 mM | 0.0622 mL | 0.3110 mL | 0.6219 mL | 1.5549 mL | |
| 30 mM | 0.0518 mL | 0.2591 mL | 0.5183 mL | 1.2957 mL | |
| 40 mM | 0.0389 mL | 0.1944 mL | 0.3887 mL | 0.9718 mL | |
| 50 mM | 0.0311 mL | 0.1555 mL | 0.3110 mL | 0.7774 mL | |
| 60 mM | 0.0259 mL | 0.1296 mL | 0.2591 mL | 0.6479 mL | |
| 80 mM | 0.0194 mL | 0.0972 mL | 0.1944 mL | 0.4859 mL | |
| 100 mM | 0.0155 mL | 0.0777 mL | 0.1555 mL | 0.3887 mL |
LO-3-63 関連分類
HY-175187 関連分類
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