Molephantin
Molephantin is a blood-brain barrier permeable anti-glioblastoma compound. Molephantin induces ROS generation, leading to mitochondrial damage, Mitophagy flux blockage and Apoptosis induction. Molephantin can suppress the PI3K/Akt/mTOR signaling pathway. Molephantin demonstrates antitumor effects against glioblastoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 50656-66-1
- 分子式: C19H22O6
- 分子量:346.37
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Molephantin (72 h) inhibits proliferation of U251 and U87 glioblastoma cells with IC50 values of 10.58 μM and 22.64 μM, respectively[1].
Molephantin (1-10 μM; 6-24 h) suppresses the PI3K/Akt/mTOR signaling pathway in U251 and U87 glioblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:U251, U87
-
Concentration:5-10 μM
-
Incubation Time:24 h
-
Result:Arrested the cell cycle in the S phase, decreasing the proportion of cells in the G0/G1 phase and increasing the proportion in the S phase
-
Cell Line:U251, U87
-
Concentration:1-10 μM
-
Incubation Time:6-24 h
-
Result:Decreased p-PI3K, p-Akt, and p-mTOR expression; reversed by NAC
Molephantin (30 mg/kg; i.p.) penetrates the blood-brain barrier in *C57BL/6* mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c nude mice (female, 7 weeks old)[1]
-
Dosage:10 mg/kg; 30 mg/kg
-
Administration:i.p.; every two days; until day 21 post-administration
-
Result:Decreased tumor volume significantly; Reduced mean tumor weight to 0.17±0.05 g (10 mg/kg) and 0.12±0.07 g compared to control; Increased expression of apoptosis-related proteins (cleaved caspase 9, cleaved caspase 7, cleaved caspase 3, cleaved PARP) in tumor tissues; Increased Cleaved caspase 3-positive cells and TUNEL-positive cells; Decreased Ki67-positive cells.
-
Animal Model:C57BL/6 mice (male, 20–22 g)[1]
-
Dosage:30 mg/kg
-
Administration:i.p.
-
Result:Detected a high chromatographic peak matching the Molephantin standard sample at 3.76 min in both plasma and brain tissue samples, confirming penetration through the blood-brain barrier.
化学情報
-
CAS 番号 50656-66-1
-
分子量 346.37
-
分子式 C19H22O6
-
SMILES
[H][C@@](C1=C)([C@@H](OC(C(C)=C)=O)C/C(C)=C\2)[C@]([C@@H](O)/C(C)=C\C2=O)([H])OC1=O
-
Structure Classification
-
Initial Source
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Molephantin 関連分類
HY-N12531 関連分類
Powered by Bioz