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Patritumab

(別名: AMG-888; U3-1287)
2 Cited Publications
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Based on 2 publication(s) in Google Scholar

Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors.

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  • 純度: 99.28%
  • CAS 番号: 1262787-83-6
  • 分子量:146.86 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Patritumab
  • Experimental Validation Results for Patritumab
  • Experimental Validation Results for Patritumab
  • Experimental Validation Results for Patritumab
  • Experimental Validation Results for Patritumab
  • Patritumab Chemical Structure
    Patritumab 構造式
CAS 番号: 1262787-83-6
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometric analysis of 1×106 MCF-7 cells labelling HER3 (red) with Patritumab (HY-P99275). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1(K214R) kappa Isotype Control (HY-P99995, blue) was used as the isotype control.

  • 1/16

    Immobilized Human HER3/ERBB3 Protein (ECD, His Tag) can bind Patritumab. The EC50 for this effect is 1.41 ng/mL.

  • 1/16

    Loaded Patritumab on AHC2 biosensor, can bind HER3 Protein, Human (HEK293, His, HY-P72625) with an affinity constant of 1.804E-09 M as determined in BLI assay.

  • 1/16

    Patritumab purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2024 Apr 15;30(8):1530-1543. [Abstract]

    Customer Validation
     Patritumab (10 μM; 2 h) reduced pHER3 after NRG1 stimulation (100 ng/mL; 15 min) in CWR-R1 cells.

  • Patritumab Chemical Structure
    1/16
  • Patritumab
  • Flow cytometric analysis of 1×106 MCF-7 cells labelling HER3 (red) with Patritumab (HY-P99275). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1(K214R) kappa Isotype Control (HY-P99995, blue) was used as the isotype control.
  • Immobilized Human HER3/ERBB3 Protein (ECD, His Tag) can bind Patritumab. The EC50 for this effect is 1.41 ng/mL.
  • Loaded Patritumab on AHC2 biosensor, can bind HER3 Protein, Human (HEK293, His, HY-P72625) with an affinity constant of 1.804E-09 M as determined in BLI assay.