製品番号: HY-N1420A

Rhamnose (monohydrate)

(別名: L-Rhamnose (monohydrate); L-ラムノース)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.95%
CAS 番号: 10030-85-0
分子式: C₆H₁₄O₆
分子量:182.17

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Rhamnose monohydrate 構造式

CAS 番号: 10030-85-0

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数量

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
- 臨床実験
化学情報
Publications (1)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

Microbial Metabolite

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

MMP アイソフォーム固有の製品をすべて表示 :

Interleukin Related アイソフォーム固有の製品をすべて表示 :

PKA アイソフォーム固有の製品をすべて表示 :

体外実験

Rhamnose (50 mM, 30 h) monohydrate can regulate the expression of P_rha target genes in Listeria monocytogenes^[1].
Rhamnose (1 mM) monohydrate can reduce the levels of pro-inflammatory interleukins and matrix metalloproteinases (MMPs) in a human dermal fibroblast (NHDF) skin aging model stimulated by advanced glycation end products (AGEs), thus possessing anti-aging potential^[2].
Rhamnose (0-300 μM, 1 h) monohydrate promotes phosphorylation of PKA substrate and HSL in SVF-derived adipocytes, stimulates PKA signaling and induces thermogenesis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

L. monocytogenes 10403S
Concentration:

50 mM
Incubation Time:

30 h
Result:

Promoted the growth of L. monocytogenes.

体内実験

Rhamnose (0.25-1 mg/mL (dissolve in water; 9 weeks; p.o.) or 300 mg/kg (7 days; i.p.)) monohydrate has anti-obesity effects in obese mice through stimulation of adipose dopamine receptors and thermogenesis^[3].
Rhamnose (5,-15 mg/kg; i.p.) monohydrate competitively inhibits the toxic effects of BEC on murine sarcoma 180 (S180) and reduces survival in sarcoma-bearing mice^[4].
Rhamnose (1-5 g/kg; once daily; 14 days; i.p.) monohydrate has antitumor activity in mice with Ehrlich’s solid tumor^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Diet induced obese mice obtained by administering high-fat diet (HFD) to 6-week-old male C57BL/6J mice for a total of 9-10 weeks^[3]
Dosage:

0.25, 0.5, 1 mg/mL (dissolve in water) or 300 mg/kg
Administration:

Oral gavage (p.o.), 9 weeks; Intraperitoneal injection (i.p.), 7 days
Result:

Reduced the total fat content of mice, improved glucose sensitivity, and promoted the expression of thermogenic genes.

Animal Model:

Herston White mice injected intraperitoneally with S180 tumor cells, 30 g, aged 8-10 weeks^[4]
Dosage:

5, 10, 15 mg/kg
Administration:

Intraperitoneal injection (i.p.); the first dose was given 0.5 h after administration of the S180 tumour cells and the remaining three doses were given at daily intervals
Result:

Reduced the survival rate of mice in a dose-dependent manner in the presence of BEC.

Animal Model:

NMRI female mouse model of subcutaneous inoculation of Ehrlich's solid tumor (SET)^[5]
Dosage:

1, 3, 5 g/kg
Administration:

Intraperitoneal injection (i.p.); once daily; 14 days
Result:

Inhibited tumor growth and prolonged the survival time of mice.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 10030-85-0
性状 Solid
分子量 182.17
分子式 C₆H₁₄O₆
Color White to off-white
SMILES

O=C[C@@H]([C@@H]([C@H]([C@H](C)O)O)O)O.O
別名

L-Rhamnose (monohydrate); L-ラムノース
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
- Plants
- other families
- Microorganisms
Widespread
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Ultrason Sonochem

Ultrasonic complexation with Lycium barbarum polysaccharide significantly enhances the aqueous solubility and bioavailability of curcumin. [Abstract]

2025 Dec:123:107673. PMID: 41223460

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (548.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.4894 mL

27.4469 mL

54.8938 mL

5 mM

1.0979 mL

5.4894 mL

10.9788 mL

10 mM

0.5489 mL

2.7447 mL

5.4894 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (27.45 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 3

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (283 KB)
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- Korean - KR (396 KB)
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COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
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MS (2659 KB)
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IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Fieseler L, et al. Rhamnose-inducible gene expression in Listeria monocytogenes. PLoS One. 2012;7(8):e43444. [Content Brief]

[2]. Novotná R, et al. Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents. Molecules. 2023 Feb 11;28(4):1728. [Content Brief]

[3]. Lv S, et al. Rhamnose Displays an Anti-Obesity Effect Through Stimulation of Adipose Dopamine Receptors and Thermogenesis. Diabetes. 2023 Mar 1;72(3):326-335. [Content Brief]

[4]. Cham BE, et al. Selective cytotoxicity for cancer cells and inhibition of cytotoxicity by rhamnose in mice with sarcoma 180. Cancer Lett. 1990 Dec 17;55(3):221-5. [Content Brief]

[5]. Tomsik P, et al. L-rhamnose and L-fucose suppress cancer growth in mice[J]. Central European Journal of Biology, 2011, 6: 1-9.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.4894 mL	27.4469 mL	54.8938 mL	137.2345 mL
	5 mM	1.0979 mL	5.4894 mL	10.9788 mL	27.4469 mL
	10 mM	0.5489 mL	2.7447 mL	5.4894 mL	13.7234 mL
	15 mM	0.3660 mL	1.8298 mL	3.6596 mL	9.1490 mL
	20 mM	0.2745 mL	1.3723 mL	2.7447 mL	6.8617 mL
	25 mM	0.2196 mL	1.0979 mL	2.1958 mL	5.4894 mL
	30 mM	0.1830 mL	0.9149 mL	1.8298 mL	4.5745 mL
	40 mM	0.1372 mL	0.6862 mL	1.3723 mL	3.4309 mL
	50 mM	0.1098 mL	0.5489 mL	1.0979 mL	2.7447 mL
	60 mM	0.0915 mL	0.4574 mL	0.9149 mL	2.2872 mL
	80 mM	0.0686 mL	0.3431 mL	0.6862 mL	1.7154 mL
	100 mM	0.0549 mL	0.2745 mL	0.5489 mL	1.3723 mL

Keywords

Rhamnose monohydrate

1 Cited Publications

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Rhamnose (monohydrate)

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MedChemExpress（MCE）の使用を引用している文献 Rhamnose monohydrate

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

MMP アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示

PKA アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Rhamnose monohydrate 関連分類

HY-N1420A 関連分類