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製品番号: HY-N15686

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Torulene

Name: Torulene
Brand: MedChemExpress
SKU: HY-N15686
Price: 1860.00 USD
Availability: PreOrder

(別名: Torulin)

Torulene (Torulin) is an orally active carotenoid with anti-cancer activity. Torulene inhibits proliferation and induces apoptosis of tumor cells via a mitochondrial signal pathway and the down-regulation of androgen receptor (AR) expression. Torulene can be used for the study of prostate cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 547-23-9
分子式: C₄₀H₅₄
分子量:534.86

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Torulene 構造式

CAS 番号: 547-23-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Bcl-2 Family アイソフォーム固有の製品をすべて表示 :

MMP アイソフォーム固有の製品をすべて表示 :

体外実験

Torulene (40 μM, 24 h) exhibits dose-dependent inhibition of the proliferation of two types of LNCaP cells and PC-3 cells^[2].
Torulene (30 μM, 12-48 h) leads to cell apoptosis time-dependently in LNCaP cells and PC-3 cells, and it is more significant in the androgen-sensitive LNCaP cells^[2].
Torulene (10-40 μM, 24 h) reduces mitochondrial membrane potential (MMP) and Bax expression and leads to an increase in intracellular calcium ion concentration and Bcl-2 expression in LNCaP cells and PC-3 cells^[2].
Torulene (10-30 μM, 24 h) significantly decreased AR and PSA protein and mRNA expression in a dose-dependent manner in LNCaP cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

LNCaP and PC-3 cells
Concentration:

0, 10, 20, 30, 40, 50 μM
Incubation Time:

24 h
Result:

Decreased cell viability approx. 50% on androgen-insensitive PC-3 cells.
Decreased cell viability approx. 15% on androgen-sensitive LNCaP cells.

RT-PCR^[2]

Cell Line:

LNCaP and PC-3 cells
Concentration:

10, 20 and 30 μM
Incubation Time:

24 h
Result:

Decreased mRNA expression of Bcl-2 from 1.00 to 0.94 (LNCap) and 0.59 (PC-3)-fold.
Increased expression of Bax from 1.00 to 2.29 (LNCap)- and 3.08 (PC-3)-fold.

体内実験

Torulene (9 and 18 mg/kg, p.o., for 2 weeks) markedly inhibits the growth of prostate cancer in nude mice injected with hormone-independent prostatic carcinoma PC-3 cells and likely associated with the apoptosis of the tumor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

PC-3 xenograft prostate tumors model established in six-week-old BALB/c male nude mice^[1]
Dosage:

9 and 18 mg/kg
Administration:

Oral administration (p.o.), for 2 weeks
Result:

Lowered the mean number of tumors from 248.13 to 50.83.
Showed tumor degeneration, apoptosis and necrosis presented.
Decreased the expression of Bcl-2 and Increased the expression of Bax.
Increased the mRNA expressions of caspase-3, 8 and 9 in tumor tissues.

化学情報

CAS 番号 547-23-9
分子量 534.86
分子式 C₄₀H₅₄
SMILES

C/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C
別名

Torulin
Structure Classification
- Others
Initial Source
- Microorganisms
Ramalina usnea thalli
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Du C, et al. The suppression of torulene and torularhodin treatment on the growth of PC-3 xenograft prostate tumors. Biochem Biophys Res Commun. 2016 Jan 22;469(4):1146-52. [Content Brief]

[2]. Chao Du, et al. The suppression of torulene and torularhodin treatment on the growth of PC-3 xenograft prostate tumors, Biochemical and Biophysical Research Communications, Volume 469, Issue 4,2016,Pages 1146-1152,ISSN 0006-291X

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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Torulene

Bcl-2 Family アイソフォーム固有の製品をすべて表示

MMP アイソフォーム固有の製品をすべて表示