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Bosutinib

(Synonyms: SKI-606)
24 Cited Publications
고객리뷰

Based on 24 publication(s) in Google Scholar

Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

  • Purity: 99.97%
  • CAS No.: 380843-75-4
  • 화학식: C26H29Cl2N5O3
  • 분자량:530.45
  • 보관:

    4°C, protect from light

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

  • Bosutinib Chemical Structure
    Bosutinib Chemical Structure
  • Experimental Validation Results for Bosutinib
  • Experimental Validation Results for Bosutinib
  • Experimental Validation Results for Bosutinib
  • Experimental Validation Results for Bosutinib
  • Experimental Validation Results for Bosutinib
CAS No.: 380843-75-4
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Cell Imaging/StainingWBFlow CytometryCell Proliferation/Viability AssayHistological Imaging/Staining
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  • Cell Proliferation/Viability Assay
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  • Bosutinib Chemical Structure
    Bosutinib Chemical Structure
    1/16
  • 1/16

    Bosutinib purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 Dec 13;10(50):eadq4274. [Abstract]

    Customer Validation
     Bright-field microscopy images of 3D sphere cultures of MIA PaCa-2R and mKRC.1 with vehicles, MRTX849, dasatinib, DGY-06-116, and Bosutinib (0.1 μM) as well as combinations, after 7 days of treatment.

  • 1/16

    Bosutinib purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 Dec 13;10(50):eadq4274. [Abstract]

    Customer Validation
     The combined use of Bosutinib (0.1 μM), DGY-06-116, or Dasatinib with MRTX849 demonstrated a similar synergistic effect in mKRC.1 cells.

  • 1/16

    Bosutinib purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 Dec 13;10(50):eadq4274. [Abstract]

    Customer Validation
     Representative images of H&E staining of the liver, lung, pancreas, and spleen from mice bearing mKRC.1 tumors, treated with either vehicle or the combination of MRTX849 and Bosutinib.

  • 1/16

    Bosutinib purchased from MedChemExpress. Usage Cited in: Life Sci Alliance. 2022 Dec 20;6(3):e202201616. [Abstract]

    Customer Validation
     Primary neurons from embryo brains of of WT rats and Tspan7−/− rats at E17 were cultured for 6 d. The WT neurons were treated without or with 10 μM Bosutinib for 4 h. Then phosphorylated and total SRC, PSD95, SYN, GluR1, and GluR2 in the primary neurons were detected with Western blot.

  • 1/16

    Bosutinib purchased from MedChemExpress. Usage Cited in: Saudi J Biol Sci. 2022 Apr;29(4):2323-2328. [Abstract]

    Customer Validation
     K562 cells were incubated with Bosutinib (BOS) (250 nM) in the absence or addition of Boc-D-FMK (5 μM) for up to 48 h. Cell cycle phase distribution was assessed using flow cytometry, PI labeling of total DNA content, and the Guava Cell Cycle Assay software module. Left to right; colored areas indicate sub-G1, G0/G1, S and G2/M phases.

  • Bosutinib