Albanol B
Based on 1 Customer Validation
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2.
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- Purity: 99.79%
- CAS No.: 87084-99-9
- 화학식: C34H22O8
- 분자량:558.53
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Albanol B (10 μM, 30 μM; 24 h) decreases cell viability of A549 cells[1].
Albanol B (30 μM; 48 h) arrrests cell cycle at G2/M phase and induces apoptosis in A549 and H1975 cells[1].
Albanol B (1-30 μM; 1-9 h) mediates the activation of ERK-1/2 and AKT in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells, BZR, NCI-H1975, and NCI-H226 cells
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Concentration:0, 1, 3, 10, and 30 μM
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Incubation Time:48 hours
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Result:Exhibited inhibitory effects on cancer cells with IC50s of 5.6 μM (A549), 8.9 μM (BZR), 12.7 μM (NCI-H1975), and 15 μM (NCI-H226), respectively.
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Cell Line:A549 and H1975 cells
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Concentration:1, 3, 10 μM
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Incubation Time:48 hours
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Result:Increased cells in G2/M phase from 9.5% to 14.34%, 18.13% and 47.9%, respectively.
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Cell Line:A549 cells
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Concentration:1 h, 3 h, 6 h, and 9 h
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Incubation Time:48 hours
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Result:Increased the phosphorylation levels of ERK1/2 and AKT in time- and concentration-dependent manners.
Did not increase the phosphorylation level of JNK and p38 MAPKs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:EX-3LL tumor-bearing mice[1]
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Dosage:50 mg/kg, 100 mg/kg
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Administration:IP; once daily for 21 days
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Result:Decreased tumor volume and weight by 48.0% and 41.0% (for 50 mg/kg treatment), and 61.3% and 57.3% (for 100 mg/kg treatment), respectively.
Chemical Information
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CAS No. 87084-99-9
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Appearance Solid
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분자량 558.53
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화학식 C34H22O8
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Color Off-white to gray
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SMILES
OC1=C(C=CC(O)=C1)[C@@]23C4=C(C5=CC=C(O)C=C5O3)C=C(C)C=C4C6=C(O)C=C(C(OC7=C8)=CC7=CC=C8O)C=C6O2
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
순도&문서
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Albanol B Related Classifications
HY-N11439 Related Classifications
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