Copy Link Print Information

Halofuginone lactate

(Synonyms: RU-19110 lactate)
22 Cited Publications
고객리뷰

Based on 22 publication(s) in Google Scholar

Halofuginone lactate, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

  • Purity: 98.32%
  • CAS No.: 82186-71-8
  • 화학식: C19H23BrClN3O6
  • 분자량:504.76
  • 보관:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Halofuginone lactate Chemical Structure
    Halofuginone lactate Chemical Structure
  • Experimental Validation Results for Halofuginone lactate
  • Experimental Validation Results for Halofuginone lactate
  • Experimental Validation Results for Halofuginone lactate
  • Experimental Validation Results for Halofuginone lactate
  • Experimental Validation Results for Halofuginone lactate
CAS No.: 82186-71-8
사이즈
가격
재고
수량
Amount: USD 0.00
Please select quantity
or
or

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Halofuginone lactate:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
주변의 대리점 찾기 Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • 용액&용해도
  • 순도&문서
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Halofuginone lactate

More
Customer Validation & Images
Bio/Physico-chemical AssayCell Imaging/StainingWBCell Proliferation/Viability AssayCell Migration/Invasion Assay
  • Cell Imaging/Staining
  • Bio/Physico-chemical Assay
  • Cell Proliferation/Viability Assay
  • Cell Migration/Invasion Assay
  • WB

All DNA/RNA Synthesis Isoforms

More

All TGF-beta/Smad Isoforms

More

All Parasite Isoforms

More

All Sodium Channel Isoforms

More

All Calcium Channel Isoforms

More
Keywords
MOQ
Minimum order quantity
100 mg

견적 받기 해외재고보유

Other size
견적 받기
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress 로그인
Register
Sign in to MedChemExpress
회원가입

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Halofuginone lactate Chemical Structure
    Halofuginone lactate Chemical Structure
    1/16
  • 1/16

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jul 25:143:156788. [Abstract]

    Customer Validation
     Cell morphology under the microscope after 24 h of 4 μM AUM in combination with 50 nM Halofuginone (HF) in the resistant cell lines and inhibition of colony formation.

  • 1/16

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e2514837122. [Abstract]

    Customer Validation
     Cultured L929, L929(Pkr-/-Hri-/-Perk-/-Gcn2-/-), L929(G3bp1-/-G3bp2-/-), L929(Zbp1-/-), L929(Ripk3-/-) and L929(Mlkl-/-) cells were treated Halofuginone (500 nM) and Halofuginone (500 nM)+IFN-β(10 ng/ml) for 42 hours; The intracellular ATP levels were measured by Cell Titer-Glo.

  • 1/16

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2024 Jul.

    Customer Validation
     Cell viability measured by MTT assay after treatment with 100, 200, 400, 800, and 1000 nM concentrations of Halofuginone (HF) in parental cells MDA-MB-231 and BT-20 for 24 h, as well as resistant cells MDA-MB-231/PR and BT-20/PR.

  • 1/16

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2024 Jul.

    Customer Validation
     Halofuginone (HF; 200 nM; 24 h) treated MDA-MB-231/PR and BT20/PR cells reduced cell invasion capabilities.

  • 1/16

    Halofuginone lactate purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Sep;178(17):3373-3394. [Abstract]

    Customer Validation
     Western blot analysis on p-Akt, Akt, p-mTOR and mTOR in control PASMCs and PASMCs treated with PDGF in the absence (vehicle control, Veh) and presence (Halofuginone; HF) of 1 μM halofuginone (for 24 h).

  • Halofuginone lactate