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Cat. No.: HY-N15686

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Torulene

Name: Torulene
Brand: MedChemExpress
SKU: HY-N15686
Price: 1860.00 USD
Availability: PreOrder

(Synonyms: Torulin)

Torulene (Torulin) is an orally active carotenoid with anti-cancer activity. Torulene inhibits proliferation and induces apoptosis of tumor cells via a mitochondrial signal pathway and the down-regulation of androgen receptor (AR) expression. Torulene can be used for the study of prostate cancer.

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CAS No.: 547-23-9
화학식: C₄₀H₅₄
분자량:534.86

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Torulene Chemical Structure

CAS No.: 547-23-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Bcl-2 Family Isoforms :

All MMP Isoforms :

In Vitro

Torulene (40 μM, 24 h) exhibits dose-dependent inhibition of the proliferation of two types of LNCaP cells and PC-3 cells^[2].
Torulene (30 μM, 12-48 h) leads to cell apoptosis time-dependently in LNCaP cells and PC-3 cells, and it is more significant in the androgen-sensitive LNCaP cells^[2].
Torulene (10-40 μM, 24 h) reduces mitochondrial membrane potential (MMP) and Bax expression and leads to an increase in intracellular calcium ion concentration and Bcl-2 expression in LNCaP cells and PC-3 cells^[2].
Torulene (10-30 μM, 24 h) significantly decreased AR and PSA protein and mRNA expression in a dose-dependent manner in LNCaP cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

LNCaP and PC-3 cells
Concentration:

0, 10, 20, 30, 40, 50 μM
Incubation Time:

24 h
Result:

Decreased cell viability approx. 50% on androgen-insensitive PC-3 cells.
Decreased cell viability approx. 15% on androgen-sensitive LNCaP cells.

RT-PCR^[2]

Cell Line:

LNCaP and PC-3 cells
Concentration:

10, 20 and 30 μM
Incubation Time:

24 h
Result:

Decreased mRNA expression of Bcl-2 from 1.00 to 0.94 (LNCap) and 0.59 (PC-3)-fold.
Increased expression of Bax from 1.00 to 2.29 (LNCap)- and 3.08 (PC-3)-fold.

In Vivo

Torulene (9 and 18 mg/kg, p.o., for 2 weeks) markedly inhibits the growth of prostate cancer in nude mice injected with hormone-independent prostatic carcinoma PC-3 cells and likely associated with the apoptosis of the tumor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

PC-3 xenograft prostate tumors model established in six-week-old BALB/c male nude mice^[1]
Dosage:

9 and 18 mg/kg
Administration:

Oral administration (p.o.), for 2 weeks
Result:

Lowered the mean number of tumors from 248.13 to 50.83.
Showed tumor degeneration, apoptosis and necrosis presented.
Decreased the expression of Bcl-2 and Increased the expression of Bax.
Increased the mRNA expressions of caspase-3, 8 and 9 in tumor tissues.

Chemical Information

CAS No. 547-23-9
분자량 534.86
화학식 C₄₀H₅₄
SMILES

C/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C
Synonyms

Torulin
Structure Classification
- Others
Initial Source
- Microorganisms
Ramalina usnea thalli
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Du C, et al. The suppression of torulene and torularhodin treatment on the growth of PC-3 xenograft prostate tumors. Biochem Biophys Res Commun. 2016 Jan 22;469(4):1146-52. [Content Brief]

[2]. Chao Du, et al. The suppression of torulene and torularhodin treatment on the growth of PC-3 xenograft prostate tumors, Biochemical and Biophysical Research Communications, Volume 469, Issue 4,2016,Pages 1146-1152,ISSN 0006-291X

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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Torulene

All Bcl-2 Family Isoforms

All MMP Isoforms