Anticancer agent 331
Anticancer agent 331 is an anticancer agent with favorable cell permeability and limited blood-brain barrier penetration. Anticancer agent 331 forms stable long-acting complexes with TNF-α, PI3K p110α, AKT1 and mTOR, and exerts cytotoxic effects on cancer cells. Anticancer agent 331 can be used in the research of colorectal cancer.
For research use only. We do not sell to patients.
- Formula: C29H20ClN5O3S2
- Molecular Weight:586.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Akt1 |
p110α |
Anticancer agent 331 (compound 5d) (4.10-49.08 µM) potently inhibits human colorectal carcinoma HCT-116 cell viability with an IC50 of 4.10 µM and exhibits high selectivity for cancer cells over human dermal fibroblast CCD-1076Sk cells, with a selectivity index of 12.0[1].
Anticancer agent 331 has a viable pharmacokinetic profile, with acceptable intestinal permeability, good predicted oral absorption, limited blood-brain barrier penetration, and two Lipinski rule of five violations typical of potent kinase inhibitors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 586.08
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Formula C29H20ClN5O3S2
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SMILES
O=S(C1=CN=CC=C1)(N2C=C(C3=CC=CC=C32)/C=N/N=C4SC=C(N\4C5=CC=CC(Cl)=C5)C6=CC=C(C=C6)O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 331 Related Classifications
HY-184487 Related Classifications
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