AMPK
AMP-activated protein kinase
AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
AMPK Isoform Specific Products
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NUAK1
(10)
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NUAK2
(5)
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AMPK
(332)
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AMPK α1β1γ1
(11)
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AMPK α2β1γ1
(8)
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AMPK α1β2γ1
(4)
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AMPK α2β2γ1
(6)
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BRSK1
(1)
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BRSK2
(1)
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HUNK
(1)
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AMPKα
(2)
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All Product Categories
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AMPK Inhibitors
(73)
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AMPK Agonists
(14)
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AMPK Antagonists
(2)
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AMPK Activators
(304)
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AMPK Modulators
(4)
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AMPK Inducers
(4)
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AMPK Substrate
(1)
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AMPK Proteins
(7)
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AMPK Related Products (453)
Related Products (453)
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Recombinant Proteins (7)
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Antibodies (17)
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AMPK Isoform Comparison
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Cinnamyl Alcohol-d9
0 ImagesCat. No.: HY-Y0078S1CAS No.: 3028869-57-7
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GSK-690693 (Standard)
0 ImagesCat. No.: HY-10249RCAS No.: 937174-76-0GSK-690693 (Standard) is the analytical standard of GSK-690693 (HY-10249). This product is intended for research and analytical applications. GSK-690693 is an ATP-competitive pan-Akt inhibitor with IC50s of 2 nM, 13 nM, 9 nM for Akt1, Akt2 and Akt3, respectively. GSK-690693 is also an AMPK inhibitor, affects Unc-51-like autophagy activating kinase 1 (ULK1) activity and robustly inhibits STING-dependent IRF3 activation.
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Phenformin hydrochloride (Standard)
0 ImagesSynonyms: Phenethylbiguanide hydrochloride (Standard)Phenformin (Phenethylbiguanide) hydrochloride (Standard) is the analytical standard of Phenformin hydrochloride (HY-16397). This product is intended for research and analytical applications. Phenformin hydrochloride (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin hydrochloride inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin hydrochloride inhibits cancer stem cells (CSCs) and possesses potent antitumor potential.
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Fenitrothion (Standard)
0 ImagesFenitrothion (Standard) is the analytical standard of Fenitrothion (HY-B1885). This product is intended for research and analytical applications. Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies.
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Saponarin (Standard)
0 ImagesCat. No.: HY-N5083RCAS No.: 20310-89-8Saponarin (Standard) is the analytical standard of Saponarin (HY-N5083). This product is intended for research and analytical applications. Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits ERK/p38, NF-κB and MAPK phosphorylation and activates AMPK. Saponarin reduces IL-1β and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders.
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IND 1316
0 ImagesCat. No.: HY-161163CAS No.: 1888473-12-8IND 1316 is an orally active, blood-brain barrier permeable AMPK activator with neuroprotective effects in animal models of Huntington's disease. IND 1316 can be used for research on neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.
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COTI-2 hydrochloride
0 ImagesCat. No.: HY-19896ACAS No.: 1204956-74-0COTI-2 hydrochloride is an orally active thiosemicarbazone anticancer agent and p53 mutant activator. COTI-2 hydrochloride induces Apoptosis. COTI-2 hydrochloride triggers the activation of AMPK and the inhibition of the mTOR pathway. COTI-2 hydrochloride induces DNA damage and replication stress responses. COTI-2 hydrochloride binds to misfolded mutant p53 proteins, thereby inducing conformational changes that restore p53 to its normal state and reactivate its function. COTI-2 hydrochloride acts on a variety of cancer cell lines and xenografts. COTI-2 hydrochloride can be used in research related to colorectal cancer, small cell lung cancer, glioblastoma, breast cancer, and ovarian cancer.
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Cinnamyl Alcohol (Standard)
0 ImagesCinnamyl Alcohol (Standard) is the analytical standard of Cinnamyl Alcohole (HY-Y0078). This product is intended for research and analytical applications. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities.
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Alisol A (Standard)
0 ImagesCat. No.: HY-N0853RCAS No.: 19885-10-0Alisol A (Standard) is the analytical standard of Alisol A (HY-N0853). This product is intended for research and analytical applications. Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity.
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ZLN024
0 ImagesCat. No.: HY-16708CAS No.: 723249-01-2ZLN024 is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.
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Dorsomorphin dihydrochloride (Standard)
0 ImagesSynonyms: Compound C dihydrochloride (Standard); BML-275 dihydrochloride (Standard)Dorsomorphin (dihydrochloride) (Standard) is the analytical standard of Dorsomorphin (dihydrochloride). This product is intended for research and analytical applications. Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).
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Metformin-13C2 (hydrochloride)
0 ImagesCat. No.: HY-B0627S1Synonyms: 1,1-Dimethylbiguanide-13C2 hydrochlorideMetformin-13C2 (1,1-Dimethylbiguanide-13C2) hydrochloride is the 13C-labeled Metformin hydrochloride (HY-17471A). Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.
