mAChR
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mAChR Related Products (484)
Related Products (484)
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LY 2033298 (Standard)
0 ImagesLY 2033298 (Standard) is the analytical standard of LY 2033298 (HY-101841). This product is intended for research and analytical applications. LY 2033298 is a selective positive allosteric modulator of the muscarinic M4 receptor. LY 2033298 can be used in the study of psychiatric disorders.
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Cevimeline hydrochloride (Standard)
0 ImagesCat. No.: HY-70020BRCAS No.: 107220-28-0Synonyms: AF102B hydrochloride (Standard)Cevimeline (hydrochloride) (Standard) is the analytical standard of Cevimeline (hydrochloride). This product is intended for research and analytical applications. Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride can cross the blood-brain barrier (BBB).
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Biperiden-d5
0 ImagesCat. No.: HY-13204ASCAS No.: 2938691-75-7Synonyms: KL 373-d5Biperiden-d5 (KL 373-d5) is deuterium labeled Biperiden. Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.
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Aclidinium Bromide (Standard)
0 ImagesSynonyms: LAS 34273 (Standard); LAS-W 330 (Standard)Aclidinium (Bromide) (Standard) is the analytical standard of Aclidinium (Bromide). This product is intended for research and analytical applications. Aclidinium Bromide (LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist. Aclidinium Bromide has the potential for chronic obstructive pulmonary disease (COPD) research.
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LG50643
0 ImagesCat. No.: HY-115413CAS No.: 111372-42-0LG50643 is a potent and selective M3 muscarinic receptor antagonist (pKi=8.64).
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Benzetimide hydrochloride (Standard)
0 ImagesSynonyms: R4929 (Standard); Dioxatrine (Standard)Benzetimide hydrochloride (Standard) (R4929 (Standard); Dioxatrine (Standard)) is the analytical standard of Benzetimide hydrochloride (HY-B1547A). This product is intended for research and analytical applications. Benzetimide hydrochloride (R4929) is a blood-brain barrier-permeable muscarinic acetylcholine receptor antagonist. Benzetimide hydrochloride blocks cholinergic receptor sites. Benzetimide hydrochloride induces mydriasis, prevents acetylcholine-induced muscle contraction, inhibits pilocarpine (HY-B0726A)-induced parasympathomimetic effects, and exhibits antisecretory activity. Benzetimide hydrochloride can be used in research related to Parkinson's disease.
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Tolterodine tartrate-d14
0 ImagesCat. No.: HY-90010SCAS No.: 1191280-48-4Synonyms: Kabi-2234-d14; PNU-200583E-d14Tolterodine tartrate-d14 (Kabi-2234-d14) is deuterium labeled Tolterodine tartrate. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.
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(S)-(+)-Dimethindene maleate (Standard)
0 ImagesCat. No.: HY-107647RCAS No.: 136152-65-3(S)-(+)-Dimethindene maleate (Standard) is the analytical standard of (S)-(+)-Dimethindene (maleate) (HY-107647). This product is intended for research and analytical applications. (S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).
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5-Hydroxymethyl tolterodine formate
0 ImagesCat. No.: HY-76569BCAS No.: 380636-49-7Synonyms: PNU-200577 formic5-Hydroxymethyl tolterodine (formate) (PNU-200577 (formic)) is an active metabolite of the muscarinic acetylcholine receptor antagonists Tolterodine (HY-A0024) and Fesoterodine (HY-70053). 5-Hydroxymethyl tolterodine (formate) is formed from tolterodine by the cytochrome P450 (CYP) isoform CYP2D6 and from fesoterodine by plasma esterases.
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Revefenacin (Standard)
0 ImagesCat. No.: HY-15851RCAS No.: 864750-70-9Synonyms: TD-4208 (Standard); GSK1160724 (Standard)Revefenacin (Standard) is the analytical standard of Revefenacin. This product is intended for research and analytical applications. Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM.
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Alvameline maleate
0 ImagesCat. No.: HY-101586ACAS No.: 219581-36-9Synonyms: Lu 25-109 maleateAlvameline (Lu 25-109) maleate is a partial agonist of M1 and an antagonist of M2/M3. Alvameline maleate competitively antagonizes contractions induced by ammonium chloride (HY-Y1269) and electrical field stimulation in human detrusor muscle, indicating its potential application in regulating bladder function. Additionally, alvameline maleate can improve cognitive function following traumatic brain injury in rats.
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Sabcomeline hydrochloride (Standard)
0 ImagesCat. No.: HY-106432ARCAS No.: 159912-58-0Synonyms: SB-202026 hydrochloride (Standard); Memric hydrochloride (Standard)Sabcomeline hydrochloride (Standard) is the analytical standard of Sabcomeline hydrochloride (HY-106432A). This product is intended for research and analytical applications. Sabcomeline (SB-202026) hydrochloride is a potent and functionally selective muscarinic M1 receptor partial agonist that improve cognition. Sabcomeline hydrochloride can be used for Alzheimer's disease research.
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Umeclidinium bromide (Standard)
0 ImagesCat. No.: HY-12100RCAS No.: 869113-09-7Synonyms: GSK573719A (Standard)Umeclidinium (bromide) (Standard) is the analytical standard of Umeclidinium (bromide). This product is intended for research and analytical applications. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.
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Deschloroclozapine (Standard)
0 ImagesDeschloroclozapine (Standard) is the analytical standard of Deschloroclozapine (HY-42110). This product is intended for research and analytical applications. Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist, with blood-brain barrier permeability. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.
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Dronedarone-d6
0 ImagesCat. No.: HY-A0016S3CAS No.: 1132693-87-8Synonyms: SR 33589-d6Dronedarone-d6 (SR 33589-d6) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4.
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Oxotremorine M iodide (Standard)
0 ImagesOxotremorine M (iodide) (Standard) is the analytical standard of Oxotremorine M (iodide) (HY-101372A). This product is intended for research and analytical applications. Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms.
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Atropine methyl bromide (Standard)
0 ImagesCat. No.: HY-112076RCAS No.: 2870-71-5Synonyms: Methylatropine bromide (Standard)Atropine methyl bromide (Standard) is the analytical standard of Atropine methyl bromide. This product is intended for research and analytical applications. Atropine methyl bromide (Methylatropine bromide), an antagonist of muscarinic acetylcholine receptors (mAChR), is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine.
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Piroheptine
0 ImagesCat. No.: HY-W683866CAS No.: 16378-21-5Piroheptine is a muscarinic acetylcholine receptor (mAChR) antagonist and dopamine reuptake inhibitor. Piroheptine blocks the high-affinity dopamine transport system, prevents MPP+ uptake into dopaminergic neurons, and exerts anticholinergic activity. Piroheptine completely prevents MPTP (HY-W114750)-induced loss of striatal dopamine and DOPAC, and increases striatal dopamine levels. Piroheptine can be used in studies related to Parkinson's disease.
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Ethopropazine hydrochloride (Standard)
0 ImagesSynonyms: Isothazine (Standard)Ethopropazine (hydrochloride) (Standard) is the analytical standard of Ethopropazine (hydrochloride) (HY-107922). This product is intended for research and analytical applications. Ethopropazine (Isothazine) hydrochloride is a potent and selective BChE inhibitor, a poor AChE inhibitor and a non-selective mAChR and NMDA antagonist. Ethopropazine hydrochloride has anticholinergic, antihistamine, antiadrenergic actions and properties. Ethopropazine hydrochloride alleviates thermal hyperalgesia in a dose dependent manner. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease.
