Antcin K
Antcin K is a selective inhibitor targeting the PI3K/Akt, NF-κB, MEK1/2-ERK, p38 and AP-1 pathways. Antcin K upregulates IL-10 expression, thereby inhibiting the production of pro-inflammatory factors, blocking monocyte adhesion, reducing tissue damage, and promoting myogenesis. Antcin K has significant anti-inflammatory, anti-damage and tissue protective activities. Antcin K is mainly used in the research of inflammation-related diseases such as periodontitis, rheumatoid arthritis, and skeletal muscle injury.
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- CAS. Nr.: 741268-13-3
- Formel: C29H44O6
- Molecular Weight:488.66
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | ED50 |
>20 μg/mL
Compound: 32
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Cytotoxicity against human HeLa cells after 3 days by MTT assay
Cytotoxicity against human HeLa cells after 3 days by MTT assay
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[PMID: 21115251] |
| HEp-2 | ED50 |
>20 μg/mL
Compound: 32
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Cytotoxicity against human Hep2 cells after 3 days by MTT assay
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
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[PMID: 21115251] |
| MCF7 | ED50 |
>20 μg/mL
Compound: 32
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Cytotoxicity against human MCF7 cells after 3 days by MTT assay
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
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[PMID: 21115251] |
Chemical Information
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CAS. Nr. 741268-13-3
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Molecular Weight 488.66
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Formel C29H44O6
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SMILES
C[C@@]12C3=C([C@H](C[C@@]1([H])[C@@](O)([C@@H](CC2)O)C)O)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC(C(C)C(O)=O)=C)C
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Structure Classification
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Initial Source
Antrodia cinnamomea
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Wu YH, et al. Antcin K suppresses proinflammatory cytokines expression via the PI3K, Akt and NF-κB pathways in human gingival fibroblasts: implications for periodontitis treatment. Cell Death Discov. 2025 Nov 22. [Content Brief]
[2]. Achudhan D, et al. Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts. Food Nutr Res. 2022 Jun 2;66. [Content Brief]
[3]. Chang TK, et al. Antcin K ameliorates cardiotoxin-induced skeletal muscle injury and inflammation via IL-10 regulation. Int J Biol Sci. 2025 Mar 19;21(6):2493-2507. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antcin K Related Classifications
HY-N9980 Related Classifications
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