Cantharidic acid
Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway.
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- CAS. Nr.: 28874-45-5
- Formel: C10H14O5
- Molecular Weight:214.22
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
218.5 μM
Compound: 4
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Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 33454654] |
| HL-60 | IC50 |
103.2 μM
Compound: 4
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Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 33454654] |
| KB 3-1 | IC50 |
79.2 μM
Compound: 4
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Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 33454654] |
| leukaemia cell line | IC50 |
>50 μM
Compound: 4
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Anticancer activity against human leukaemia cell line assessed as cell growth inhibition
Anticancer activity against human leukaemia cell line assessed as cell growth inhibition
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[PMID: 33454654] |
Chemical Information
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CAS. Nr. 28874-45-5
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Molecular Weight 214.22
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Formel C10H14O5
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SMILES
OC([C@@]([C@@]1(C)C(O)=O)([C@@H]2O[C@H]1CC2)C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cantharidic acid Related Classifications
HY-137135 Related Classifications
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