Catenarin
Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice[1][2].
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 476-46-0
- Formel: C15H10O6
- Molecular Weight:286.24
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Calcium Channel Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Calu-1 | IC50 |
>100 μM
Compound: 11
|
Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
|
[PMID: 11374975] |
| HeLa | IC50 |
>100 μM
Compound: 11
|
Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
|
[PMID: 11374975] |
| K562 | IC50 |
>100 μM
Compound: 11
|
Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
|
[PMID: 11374975] |
| Raji | IC50 |
>100 μM
Compound: 11
|
Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
|
[PMID: 11374975] |
| RAW264.7 | IC50 |
41.32 μM
Compound: 6, Catenarin
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 15 mins prior to LPS challenge measured after 20 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 15 mins prior to LPS challenge measured after 20 hrs by Griess assay
|
[PMID: 24016057] |
| Vero | IC50 |
>100 μM
Compound: 11
|
Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
|
[PMID: 11374975] |
| WISH | IC50 |
>100 μM
Compound: 11
|
Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
|
[PMID: 11374975] |
Catenarin (0-2.5 μg/mL, 1 h) inhibits CCR5 (IC50 = 0.24 μg/mL) mediated chemotaxis in JK-EF1α-CCR5 cells and CXCR4 (IC50 = 0.46 μg/mL) mediated chemotaxis in Jurkat cells[1].
Catenarin (1-5 μg/mL, 1 h) inhibits calcium mobilization in CCR5 and CXCR4 pathways in JK-EF1α-CCR5 cells and Jurkat cells[1].
Catenarin (1 μg/mL, 0-15 min) inhibits the activation of MAPK cascades in CCR5 and CXCR4 pathways in JK-EF1α-CCR5 cells and Jurkat cells[1].
Catenarin (1 μg/mL, 1 h) does not affect surface expression of CCR5 and CXCR4 receptors in JK-EF1α-CCR5 cells or Jurkat cells[1].
Catenarin (0.1-0.2 μg/mL, 0-10 h) exhibits significant inhibitory effects against Gram-positive bacteria with a minimum inhibitory concentration (MIC) of 1 μg/mL in complex media and 0.2 μg/mL in synthetic media[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Jurkat cells and JK-EF1α-CCR5 cells
-
Concentration:0.5 μg/mL
-
Incubation Time:8 h
-
Result:Abolished the movement of Jurkat cells and JK-EF1α-CCR5 cells toward SDF-1β and MIP-1β.
Abolished Jurkat cell migration mediated by MKK6 and MKK7.
-
Cell Line:Jurkat cells, JK-EF1α-CCR5 cells and JK-EF1α-CCR5 cells
-
Concentration:1 μg/mL
-
Incubation Time:0, 5, 10, 15 min
-
Result:Inhibited the phosphorylation of the p38 and JNK in JK-EF1α-CCR5 and Jurkat cells in response to MIP-1β and SDF-1β.
Increased the phosphorylation of ERK1/2.
Reduced the phosphorylation of MKK6 in K-EF1α-CCR5 cells triggered by MIP-1β and Jurkat cells triggered by SDF-1β.
Decreased the phosphorylation of MKK7.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female NOD mice (4-30 weeks)[1]
-
Dosage:0.4, 4, and 20 mg/kg
-
Administration:i.p. three times per week for 26 weeks
-
Result:Reduced diabetes in the age-matched mice by 33%, 86%, and 100%.
Prevented T1D in NOD mice to a greater extent than Aspirin (acetylsalicylic acid) (HY-14654).
Showed a marginal-to-modest islet destruction and leukocyte infiltration at 4 mg/kg and over.
Reduced the level of blood glucose and HbA1C at 4 mg/kg and over.
Reduced the number of CD8+ T cells and dendritic cells.
Chemical Information
-
CAS. Nr. 476-46-0
-
Molecular Weight 286.24
-
Formel C15H10O6
-
SMILES
O=C1C2=C(C(C3=C(C=C(C)C(O)=C13)O)=O)C(O)=CC(O)=C2
-
Synonyms
Katenarin
-
Structure Classification
-
Initial Source
Conoideocrella krungchingensis
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Shen MY, et al. Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways. Evid Based Complement Alternat Med. 2012;2012:982396. [Content Brief]
[2]. Anke H, et al. The anthraquinones of the Aspergillus glaucus group. I. Occurrence, isolation, identification and antimicrobial activity. Arch Microbiol. 1980 Jul;126(3):223-30. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Powered by Bioz