CDC42 - cell division cycle 42 Gene

Also Known as TKS; G25K; CDC42Hs

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 998

About CDC42

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,052,709-22,101,360 (from NCBI)

This gene has 24 transcripts (splice variants), 237 orthologues, 22 paralogues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 88.8), colon (RPKM 72.7) and 25 other tissues.

Summary

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae CDC 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

CDC42 Products (3)

mRNA	Protein	Name
NM_001039802.2	NP_001034891.1	cell division control protein 42 homolog isoform 1 precursor
NM_001791.4	NP_001782.1	cell division control protein 42 homolog isoform 1 precursor
NM_044472.3	NP_426359.1	cell division control protein 42 homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GBD domain binding	IPI IPI: Inferred from physical interaction	8625410	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	8625410	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	19787194	GOA
enables apolipoprotein A-I receptor binding	IPI IPI: Inferred from physical interaction	16443932	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9748241	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7493928	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	19039103	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8625410	GOA
enables thioesterase binding	IPI IPI: Inferred from physical interaction	12612085	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	21435037	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11035016	GOA
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	26465210	GOA
involved in cell junction assembly	IMP IMP: Inferred from mutant phenotype	22891260	GOA
involved in establishment of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	22891260	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	26051942	GOA
involved in modulation by host of viral process	IMP IMP: Inferred from mutant phenotype	19376974	GOA
involved in negative regulation of protein-containing complex assembly	IPI IPI: Inferred from physical interaction	11584266	GOA
involved in neuropilin signaling pathway	IMP IMP: Inferred from mutant phenotype	26051942	GOA
involved in phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	26465210	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	21435037	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20023705	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	15642749	GOA
involved in positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	26051942	GOA
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	8625410	GOA
involved in positive regulation of pseudopodium assembly	IDA IDA: Inferred from direct assay	11035016	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	8625410	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	11807099	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	26051942	GOA
involved in regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	15642749	GOA
involved in regulation of filopodium assembly	IDA IDA: Inferred from direct assay	14978216	GOA
involved in regulation of lamellipodium assembly	IGI IGI: Inferred from genetic interaction	8625410	GOA
involved in regulation of stress fiber assembly	IGI IGI: Inferred from genetic interaction	8625410	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Golgi transport complex	IMP IMP: Inferred from mutant phenotype	16380373	GOA
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11260256	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
located in filopodium	IDA IDA: Inferred from direct assay	11035016	GOA
located in membrane	IDA IDA: Inferred from direct assay	11807099	GOA
located in membrane	IMP IMP: Inferred from mutant phenotype	22801373	GOA
located in midbody	IDA IDA: Inferred from direct assay	15642749	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	15642749	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	21048939	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	21048939	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11260256	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA
located in spindle midzone	IDA IDA: Inferred from direct assay	15642749	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC42 Protein Structure

Ras

0
100
191 a.a.

Protein Preferred Names	Protein Names
cell division control protein 42 homolog	G25K GTP-binding protein

CDC42 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC42	P60953	PAK2	Homo sapiens	Q13177	Y2H Pooling	20936779
Intra	CDC42	P60953	PAK2	Homo sapiens	Q13177	Validated Y2H	25416956
Intra	CDC42	P60953	PAK2	Homo sapiens	Q13177	Validated Y2H	32296183
Intra	CDC42	P60953	PAK2	Homo sapiens	Q13177	Y2H Array	25416956
Intra	CDC42	P60953	PAK6	Homo sapiens	Q9NQU5	Anti Tag CoIP	31980649
Intra	CDC42	P60953	CDC42EP1	Homo sapiens	Q00587-2	Validated Y2H	32296183
Intra	CDC42	P60953	CDC42EP1	Homo sapiens	Q00587-2	Y2H Array	32296183
Intra	CDC42	P60953	CDC42EP1	Homo sapiens	Q00587-2	Y2H Prey Pooling	32296183
Cross	CDC42	P60953	sopB	Salmonella typhimurium	O30916	Pull Down	21435037
Intra	CDC42	P60953	HDAC7	Homo sapiens	Q8WUI4-6	Validated Y2H	32296183
Intra	CDC42	P60953	PAK1	Homo sapiens	Q13153	Imaging	8107774
Intra	CDC42	P60953	PAK1	Homo sapiens	Q13153	Pull Down	19596003
Intra	CDC42	P60953	PAK1	Homo sapiens	Q13153	Y2H Pooling	20936779
Intra	CDC42	P60953	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	14676191
Intra	CDC42	P60953	PRKCI	Homo sapiens	P41743	Y2H	11260256
Intra	CDC42	P60953	PRKCI	Homo sapiens	P41743	CoIP	11260256
Intra	CDC42	P60953	PARD6B	Homo sapiens	Q9BYG5	Y2H Prey Pooling	32296183
Intra	CDC42	P60953	PARD6B	Homo sapiens	Q9BYG5	Pull Down	11260256
Intra	CDC42	P60953	PARD6B	Homo sapiens	Q9BYG5	CoIP	11260256
Intra	CDC42	P60953	PARD6B	Homo sapiens	Q9BYG5	Y2H Array	32296183
Intra	CDC42	P60953	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	25416956
Intra	CDC42	P60953	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	32296183
Intra	CDC42	P60953	PARD6B	Homo sapiens	Q9BYG5	Y2H	11260256
Intra	CDC42	P60953	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	14676191
Intra	CDC42	P60953	PARD6G	Homo sapiens	Q9BYG4	Y2H	11260256
Intra	CDC42	P60953	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	14676191
Intra	CDC42	P60953	PARD6G	Homo sapiens	Q9BYG4	Pull Down	11260256
Intra	CDC42	P60953	IQGAP1	Homo sapiens	P46940	CoIP	8670801
Intra	CDC42	P60953	IQGAP1	Homo sapiens	P46940	Pull Down	8702968
Intra	CDC42	P60953	IQGAP1	Homo sapiens	P46940	Anti Tag CoIP	35271311
Intra	CDC42	P60953	IQGAP1	Homo sapiens	P46940	CoIP	8798539
Intra	CDC42	P60953	IQGAP1	Homo sapiens	P46940	Anti Tag CoIP	31980649
Intra	CDC42	P60953	IQGAP1	Homo sapiens	P46940	Pull Down	8670801
Intra	CDC42	P60953	IQGAP1	Homo sapiens	P46940	Pull Down	8798539
Intra	CDC42	P60953	IQGAP1	Homo sapiens	P46940	Anti Tag CoIP	26496610
Intra	CDC42	P60953	IQGAP1	Homo sapiens	P46940	IF	18809683
Intra	CDC42	P60953	CDC42EP2	Homo sapiens	O14613	Y2H Prey Pooling	32296183
Intra	CDC42	P60953	CDC42EP2	Homo sapiens	O14613	Y2H Array	25416956
Intra	CDC42	P60953	CDC42EP2	Homo sapiens	O14613	Y2H Array	32296183
Intra	CDC42	P60953	CDC42EP2	Homo sapiens	O14613	Y2H Pooling	20936779
Intra	CDC42	P60953	CDC42EP2	Homo sapiens	O14613	Y2H Prey Pooling	25416956
Intra	CDC42	P60953	WAS	Homo sapiens	P42768	Y2H	22252508
Intra	CDC42	P60953	WAS	Homo sapiens	P42768	Y2H Array	31515488
Intra	CDC42	P60953	WAS	Homo sapiens	P42768	Y2H Array	25502805
Intra	CDC42	P60953	WAS	Homo sapiens	P42768	Imaging	8625410
Intra	CDC42	P60953	WAS	Homo sapiens	P42768	SPR	9660763
Intra	CDC42	P60953	RIT1	Homo sapiens	Q92963	Confocal	29734338
Cross	CDC42	P60953	Pak3	Mus musculus	Q61036	Pull Down	23022564
Intra	CDC42	P60953	BAIAP2	Homo sapiens	Q9UQB8	Pull Down	21311754
Intra	CDC42	P60953	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	21454543
Intra	CDC42	P60953	BAIAP2	Homo sapiens	Q9UQB8-4	Pull Down	19171758
Intra	CDC42	P60953	BAIAP2	Homo sapiens	Q9UQB8-4	Pull Down	24076653
Intra	CDC42	P60953	CDC42BPA	Homo sapiens	Q5VT25	Far-WB	15194684
Intra	CDC42	P60953	CDC42BPA	Homo sapiens	Q5VT25	Anti Tag CoIP	35271311
Intra	CDC42	P60953	ARHGDIA	Homo sapiens	P52565	Anti Tag CoIP	31980649
Intra	CDC42	P60953	PAK4	Homo sapiens	O96013	Anti Tag CoIP	22653441
Intra	CDC42	P60953	PAK4	Homo sapiens	O96013	Y2H Pooling	20936779
Intra	CDC42	P60953	PAK4	Homo sapiens	O96013	Anti Tag CoIP	29734338
Intra	CDC42	P60953	APC	Homo sapiens	P25054	FRET	21311754
Intra	CDC42	P60953	APC	Homo sapiens	P25054	Pull Down	21311754
Intra	CDC42	P60953	APC	Homo sapiens	P25054	Confocal	21311754
Intra	CDC42	P60953	PAK5	Homo sapiens	Q9P286	Y2H Prey Pooling	32296183
Intra	CDC42	P60953	PAK5	Homo sapiens	Q9P286	Validated Y2H	32296183
Intra	CDC42	P60953	PAK5	Homo sapiens	Q9P286	Y2H Array	32296183
Intra	CDC42	P60953	CDC42EP1	Homo sapiens	Q00587	Validated Y2H	25416956
Intra	CDC42	P60953	CDC42EP1	Homo sapiens	Q00587	Y2H Array	25416956
Intra	CDC42	P60953	CDC42EP1	Homo sapiens	Q00587	Y2H Pooling	16189514
Intra	CDC42	P60953	CDC42EP1	Homo sapiens	Q00587	Anti Tag CoIP	31980649
Intra	CDC42	P60953	CDC42EP1	Homo sapiens	Q00587	Anti Tag CoIP	35271311
Intra	CDC42	P60953	CDC42EP1	Homo sapiens	Q00587	Y2H	21988832
Intra	CDC42	P60953	ABCA1	Homo sapiens	O95477	Anti Tag CoIP	16443932
Intra	CDC42	P60953	ABCA1	Homo sapiens	O95477	Anti Bait CoIP	16443932
Cross	CDC42	P60953	Pard6b	Mus musculus	Q9JK83	X-Ray Diffraction	12606577
Cross	CDC42	P60953	Pard6b	Mus musculus	Q9JK83	Y2H	10934474
Cross	CDC42	P60953	Pard6b	Mus musculus	Q9JK83	CoIP	10934474
Cross	CDC42	P60953	Pard6b	Mus musculus	Q9JK83	Anti Tag CoIP	12606577
Intra	CDC42	P60953	PARD6A	Homo sapiens	Q9NPB6	Y2H	10934474
Intra	CDC42	P60953	PARD6A	Homo sapiens	Q9NPB6	Anti Tag CoIP	14676191
Intra	CDC42	P60953	PARD6A	Homo sapiens	Q9NPB6	Y2H	11260256
Intra	CDC42	P60953	WASL	Homo sapiens	O00401	Y2H Pooling	20936779
Cross	CDC42	P60953	Bin1	Drosophila melanogaster	Q9VEX9	Y2H	9082982
Cross	CDC42	P60953	Bin1	Drosophila melanogaster	Q9VEX9	Pull Down	9082982
Cross	CDC42	P60953	Wasl	Rattus norvegicus	O08816	Far-WB	9422512

Cross: Cross-species interaction Intra: Intraspecies interaction

CDC42 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82859	Phospho-Rac1/CDC42 (Ser71) Antibody (YA2604)	WB	Human
HY-P83703	CDC42 Antibody (YA3440)	WB, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Takenouchi-Kosaki Syndrome	Macrothrombocytopenia-Lymphedema-Developmental Delay-Facial Dysmorphism-Camptodactyly Syndrome TKS Macrothrombocytopenia And Mental Retardation Syndrome
Neonatal-Onset Severe Multisystemic Autoinflammatory Disease With Increased Il18	Neonatal-Onset Autoinflammation-Cytopenia-Facial Dysmorphism Syndrome Neonatal-Onset Severe Multisystemic Autoinflammatory Disease With Increased Interleukin 18
Immune System Disease	Abnormality Of The Immune System Immune System And Disorders Immune System Diseases
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Temperature-Sensitive Lethal Mutation
Aarskog-Scott Syndrome	Aarskog Syndrome Faciogenital Dysplasia Faciodigitogenital Syndrome AAS Fgdy X-Linked Aarskog Syndrome Intellectual Developmental Disorder, X-Linked, Syndromic 16 Aarskog Syndrome, X-Linked Intellectual Developmental Disorder, X-Linked Syndromic 16 Greig'S Syndrome Aarskog Scott Syndrome Aarskog Disease Scott Aarskog Syndrome Facio-Digito-Genital Dysplasia Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder Aarskog-Scott Syndrome ) Syndrome
Clostridium Difficile Colitis	Pseudomembranous Colitis Colitis Pseudomembranous Enterocolitis, Pseudomembranous Pseudomembranous Enterocolitis Clostridium Difficile Infection
Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis	Neutrophil Immunodeficiency Syndrome IMD73A Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis Rac 2 Deficiency
Charcot-Marie-Tooth Disease, Type 4h	Charcot-Marie-Tooth Disease Type 4h CMT4H Charcot-Marie-Tooth Neuropathy Type 4h Charcot-Marie-Tooth Disease, Autosomal Recessive, Type 4h Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4h Charcot-Marie-Tooth Neuropathy, Type 4h Autosomal Recessive Charcot-Marie-Tooth Disease Type 4h Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4h Charcot-Marie-Tooth Disease 4h Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4h
Unilateral Focal Polymicrogyria
Adams-Oliver Syndrome	Adams Oliver Syndrome Aos Congenital Scalp Defects With Distal Limb Reduction Anomalies Aplasia Cutis Congenita With Terminal Transverse Limb Defects Congenital Scalp Defects With Distal Limb Anomalies Limb, Scalp And Skull Defects Limb Scalp And Skull Defects Absence Defect Of Limbs, Scalp, And Skull
Pancytopenia
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Constipation
Neutropenia, Severe Congenital, X-Linked	X-Linked Severe Congenital Neutropenia XLN SCNX Severe Congenital Neutropenia X-Linked Neutropenia, Congenital, Severe, X-Linked
Asbestos-Related Lung Carcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Spinal Cord Lipoma	Lipoma Of Spinal Cord
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Salmonellosis	Salmonella Infections Salmonella Infection
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Parameningeal Embryonal Rhabdomyosarcoma
Prolapse Of Urethra	Urethrocele
Periventricular Nodular Heterotopia	Periventricular Heterotopia Pvnh Familial Nodular Heterotopia Heterotopia, Periventricular Periventricular Heterotopia, X-Linked
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-I0400	N-Acetylneuraminic acid		99.95%	Phase 1
HY-112842	MBQ-167	Inhibitor	99.85%	Phase 1

Pre-clinical Phase

Bioactive Molecules (40)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12755	ML141		99.96%	Unkown
HY-12646	Rhosin hydrochloride		99.94%	Unkown
HY-12874	CASIN		99.89%	Unkown
HY-12810	EHop-016	Inhibitor	99.38%	Unkown
HY-12646A	Rhosin		98.74%	Unkown
HY-111424	BDP9066	Inhibitor	98.18%	Unkown
HY-13963	ZCL278	Inhibitor	98.49%	Unkown
HY-115376	Z62954982	Inhibitor	99.38%	Unkown
HY-N0710	alpha-Cyperone		99.68%	Unkown
HY-N2438	Methylophiopogonanone B		99.84%	Unkown
HY-113849	MLS-573151	Inhibitor	99.66%	Unkown
HY-136383	AZA1		98.17%	Unkown
HY-136379	CID44216842	Inhibitor	99.84%	Unkown
HY-B0580B	(R)-Ketorolac	Inhibitor	99.35%	Unkown
HY-10943	GNF-7	Inhibitor	99.70%	Unkown
HY-15031	l-Naproxen	Inhibitor	99.63%	Unkown
HY-149464	ARN22089	Inhibitor	98.18%	Unkown
HY-D2415	BODIPY-FL staurosporine		95.4%	Unkown
HY-111424A	(R)-BDP9066	Inhibitor	98.49%	Unkown
HY-121667	Scaff10-8	Inhibitor	99.11%	Unkown
HY-RS02300	CDC42 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-116269	AZA197		98.71%	Unkown
HY-152095	PPI-GIT1/β-Pix PPI-IN-1	Inhibitor	99.01%	Unkown
HY-170327	ZCL279	Inhibitor	99.20%	Unkown
HY-RS23116	Cdc42 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-111423	BDP8900	Inhibitor	/	Unkown
HY-13963S	ZCL278-13C		/	Unkown
HY-149921	Antiangiogenic agent 3	Inhibitor	/	Unkown
HY-161736	ARN25499	Inhibitor	/	Unkown
HY-172917	Rho GTPase inhibitor 1	Inhibitor	/	Unkown
HY-183246	Rac/Cdc42-IN-1	Inhibitor	/	Unkown
HY-RS02301	CDC42BPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02302	CDC42BPB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02303	CDC42EP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02304	CDC42EP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02305	CDC42EP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-167828	ARN25062	Inhibitor	/	Unkown
HY-N15267	Ovalitenone	Inhibitor	/	Unkown
HY-N16021	4A-MPLA ammonium		/	Unkown
HY-RS16681	Cdc42 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDC42	VGNC	VGNC:97251
Rattus norvegicus	CDC42	RGD	RGD:71043
Mus musculus	CDC42	MGD	MGI:106211
Macaca mulatta	CDC42	VGNC	VGNC:106339
Others	CDC42	NCBI