Ilmofosine
Ilmofosine (BM41440) is a potent and selective protein kinase C inhibitor. Ilmofosine induces cell cycle arrest at the G2 phase. Ilmofosine also is an anti-leishmanial agent.
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- CAS No.: 83519-04-4
- Formule: C26H56NO5PS
- Masse moléculaire:525.77
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-427 | IC50 |
20 μM
Compound: rac-1(ilmofosine)
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Inhibition of large cell lung carcinoma (A427)
Inhibition of large cell lung carcinoma (A427)
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[PMID: 9135036] |
| A549 | IC50 |
10 μM
Compound: rac-1(ilmofosine)
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Inhibition of non-small-cell lung adenocarcinoma (A549)
Inhibition of non-small-cell lung adenocarcinoma (A549)
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[PMID: 9135036] |
| MCF7 | IC50 |
2 μM
Compound: rac-1(ilmofosine)
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Inhibition of proliferation of breast adenocarcinoma cell line MCF-7
Inhibition of proliferation of breast adenocarcinoma cell line MCF-7
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[PMID: 9135036] |
| RBL-2H3 | IC50 |
6.4 μM
Compound: 3
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Inhibition of rat RBL2H3 cell granulation assessed as reduction of beta hexasaminidase release
Inhibition of rat RBL2H3 cell granulation assessed as reduction of beta hexasaminidase release
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[PMID: 20153565] |
Ilmofosine inhibits amastigotes of Leishmania donovani and an antimony-resistant line of L. infantum with ED50 values of 3.73, 3.46 µM[1].
Ilmofosine (15 µM; 48 h) induces cell cycle arrest at G2 phase in CA46 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CA46 cells
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Concentration:15 µM
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Incubation Time:48 h
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Result:Induced cell cycle arrest at G2-phase.
Chemical Information
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CAS No. 83519-04-4
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Masse moléculaire 525.77
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Formule C26H56NO5PS
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SMILES
CCCCCCCCCCCCCCCCSCC(COC)COP(OCC[N+](C)(C)C)([O-])=O
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Synonyms
BM41440
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Croft SL, et al. Antileishmanial activity of the ether phospholipid ilmofosine. Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87(2):217-9. [Content Brief]
[2]. Hofmann J, et al. The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents. Biochem Biophys Res Commun. 1994 Mar 15;199(2):937-43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ilmofosine Related Classifications
HY-133838 Related Classifications
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