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Art. -Nr.: HY-107101

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(5R)-5-Hydroxytriptolide

(Synonyms: PG 701; LLDT-8; 5α-Hydroxytriptolide)

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(5R)-5-Hydroxytriptolide is an extracted compound from Tripterygium, and shows lower cell cytotoxicity and higher immunosuppressive activity. (5R)-5-Hydroxytriptolide can be used for study of rheumatoid arthritis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.67%
CAS. Nr.: 583028-68-6
Formel: C₂₀H₂₄O₇
Molecular Weight:376.40

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(5R)-5-Hydroxytriptolide Chemical Structure

CAS. Nr.: 583028-68-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.04 nM Compound: 7; LLDT-8	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 31121546]
BGC-823	IC₅₀	1.5 μM Compound: 7; LLDT-8	Cytotoxicity against human BGC823 cells assessed as decrease in cell viability by MTT assay Cytotoxicity against human BGC823 cells assessed as decrease in cell viability by MTT assay	[PMID: 31121546]
HeLa	IC₅₀	0.34 μM Compound: 7; LLDT-8	Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay	[PMID: 31121546]
HL-60	IC₅₀	0.04 nM Compound: 7; LLDT-8	Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 31121546]
HL-60	IC₅₀	0.47 μM Compound: 7; LLDT-8	Cytotoxicity against human HL60 cells assessed as decrease in cell viability by MTT assay Cytotoxicity against human HL60 cells assessed as decrease in cell viability by MTT assay	[PMID: 31121546]
KB	IC₅₀	0.3 μM Compound: 7; LLDT-8	Cytotoxicity against human KB cells assessed as decrease in cell viability by MTT assay Cytotoxicity against human KB cells assessed as decrease in cell viability by MTT assay	[PMID: 31121546]
MCF7	IC₅₀	0.04 nM Compound: 7; LLDT-8	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 31121546]
MCF7	IC₅₀	1.05 μM Compound: 7; LLDT-8	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by MTT assay	[PMID: 31121546]
MKN-28	IC₅₀	0.04 nM Compound: 7; LLDT-8	Cytotoxicity against human MKN28 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human MKN28 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 31121546]
P388	IC₅₀	0.04 nM Compound: 7; LLDT-8	Cytotoxicity against mouse P388 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against mouse P388 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 31121546]
PC-3	IC₅₀	0.275 μM Compound: 4	Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation by sulforhodamine B assay Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation by sulforhodamine B assay	[PMID: 25467158]
U-251	IC₅₀	0.488 μM Compound: 4	Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay	[PMID: 25467158]

Chemical Information

CAS. Nr. 583028-68-6
Appearance Solid
Molecular Weight 376.40
Formel C₂₀H₂₄O₇
Color White to off-white
SMILES

CC([C@@]12[C@H]([C@H]3[C@]4([C@@]5(C)CCC6=C(COC6=O)[C@]5(O)C[C@H]7[C@@]4(O7)[C@@H]2O)O3)O1)C
Synonyms

PG 701; LLDT-8; 5α-Hydroxytriptolide
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Guo S, et al. (5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients. Sci Rep. 2019;9(1):11155. Published 2019 Aug 1. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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Reinheit & Dokumentation
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(5R)-5-Hydroxytriptolide

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Alle HIV Isoform-spezifische Produkte anzeigen

Alle JNK Isoform-spezifische Produkte anzeigen

Alle NF-κB Isoform-spezifische Produkte anzeigen

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

(5R)-5-Hydroxytriptolide Related Classifications

HY-107101 Related Classifications