Cat. No.: HY-N7688

Regaloside B

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Regaloside B is a phenylpropane. Regaloside B can be isolated from Lilium longiflorum. Regaloside B can inhibit the expression of VCAM-1, iNOS, and COX-2, with a p-p65/p-65 ratio. Regaloside B inhibits the mRNA of various chemokines and angiogenic factors (CXCL9, CXCL10, IL8, IDO). Regaloside B has anti-inflammatory activity. Regaloside B can be used for osteogenic differentiation research.

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Pureté: 99.90%
CAS No.: 114420-67-6
Formule: C₂₀H₂₆O₁₁
Masse moléculaire:442.41

Stockage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Regaloside B Chemical Structure

CAS No.: 114420-67-6

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]^[2]^[3]

iNOS

COX-2

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In Vitro

Regaloside B (50 μg/mL; 2-24 h) inhibits iNOS expression, reduces COX-2 expression, and decreases the p-p65/p-65 ratio in RAW264.7 cells^[1]. Regaloside B (400 μg/mL; 1 h) significantly inhibits TNF-α/IFN-γ-induced mRNA expression of chemotactic and angiogenic factors in human umbilical cord mesenchymal stem cells (hUCMSCs)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

RAW264.7 cells
Concentration:

50 μg/mL
Incubation Time:

2 h; 24 h
Result:

Inhibited the expression of iNOS to 26.2.
Decreased the expression of COX-2 to 98.9.
Decreased the ratio of p-p65 to p65 by 43.2.

Western Blot Analysis^[1]

Cell Line:

HASMCs
Concentration:

50 μg/mL
Incubation Time:

2 h
Result:

Markedly inhibited the expression of VCAM-1 by 33.8.

Real Time qPCR^[3]

Cell Line:

Human umbilical cord-derived mesenchymal stem cells (hUCMSCs)
Concentration:

400 μg/mL
Incubation Time:

1 h
Result:

Inhibited the mRNA expression of CCL5, CXCL9, CXCL10, IL8, ICAM, VCAM, and IDO.

Cell Viability Assay^[3]

Cell Line:

Human umbilical cord-derived mesenchymal stem cells (hUCMSCs)
Concentration:

25; 50; 100; 200; 400; 800; 1600 μg/mL
Incubation Time:

24 h
Result:

Did not show adverse effects on cell viability.

Chemical Information

CAS No. 114420-67-6
Appearance Solid
Masse moléculaire 442.41
Formule C₂₀H₂₆O₁₁
Color White to off-white
SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1O[C@H](COC(/C=C/C2=CC=C(O)C=C2)=O)COC(C)=O
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
- Phenols
- Monophenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (226.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2603 mL

11.3017 mL

22.6035 mL

5 mM

0.4521 mL

2.2603 mL

4.5207 mL

10 mM

0.2260 mL

1.1302 mL

2.2603 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Thi NN, et, al. Phenylpropanoids from Lilium Asiatic hybrid flowers and their anti-inflammatory activities. Applied Biological Chemistry. 2017; 60: 527–533.

[2]. Kim BR, et, al. Purification of Phenylpropanoids from the Scaly Bulbs of Lilium Longiflorum by CPC and Determination of Their DPP-IV Inhibitory Potentials. ACS Omega. 2020 Feb 20; 5(8): 4050-4057. [Content Brief]

[3]. Chen G, et al. Total Glycosides and Regaloside B from Lily: Potential Therapeutic Agents for Osteogenic Differentiation, Migration, and Angiogenesis. ACS Omega. 2025 Jul 20;10(29):31638-31648. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2603 mL	11.3017 mL	22.6035 mL	56.5087 mL
	5 mM	0.4521 mL	2.2603 mL	4.5207 mL	11.3017 mL
	10 mM	0.2260 mL	1.1302 mL	2.2603 mL	5.6509 mL
	15 mM	0.1507 mL	0.7534 mL	1.5069 mL	3.7672 mL
	20 mM	0.1130 mL	0.5651 mL	1.1302 mL	2.8254 mL
	25 mM	0.0904 mL	0.4521 mL	0.9041 mL	2.2603 mL
	30 mM	0.0753 mL	0.3767 mL	0.7534 mL	1.8836 mL
	40 mM	0.0565 mL	0.2825 mL	0.5651 mL	1.4127 mL
	50 mM	0.0452 mL	0.2260 mL	0.4521 mL	1.1302 mL
	60 mM	0.0377 mL	0.1884 mL	0.3767 mL	0.9418 mL
	80 mM	0.0283 mL	0.1413 mL	0.2825 mL	0.7064 mL
	100 mM	0.0226 mL	0.1130 mL	0.2260 mL	0.5651 mL

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Regaloside B

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Voir tous les produits spécifiques à Isoform NO Synthase

Voir tous les produits spécifiques à Isoform COX

Voir tous les produits spécifiques à Isoform NF-κB

Voir tous les produits spécifiques à Isoform CXCR

Voir tous les produits spécifiques à Isoform Interleukin Related

Voir tous les produits spécifiques à Isoform Indoleamine 2,3-Dioxygenase (IDO)

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table