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Cat. No.: HY-14539S5

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Clozapine-d₁₁

Name: Clozapine-d11
Brand: MedChemExpress
SKU: HY-14539S5
Availability: PreOrder

(Synonyms: HF 1854-d₁₁; ZINC000019796155-d₁₁)

Clozapine-d₁₁ (HF 1854-d₁₁) is the deuterium labeled Clozapine (HY-14539). Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K_i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K_is of 9.5 nM and 4 nM, respectively Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC₅₀ = 11 nM).

For research use only. We do not sell to patients.

CAS No.: 1233341-42-8
Formula: C₁₈H₈D₁₁ClN₄
Molecular Weight:337.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Clozapine-d₁₁ Chemical Structure

CAS No.: 1233341-42-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Adrenergic Receptor Isoforms :

All mAChR Isoforms :

All Ligands for E3 Ligase Isoforms :

All Dopamine Receptor Isoforms :

All 5-HT Receptor Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1233341-42-8
Unlabeled Cas 5786-21-0
Molecular Weight 337.89
Formula C₁₈H₈D₁₁ClN₄
SMILES

ClC1=CC=C2NC3=CC=CC=C3C(N(C([2H])([2H])C4([2H])[2H])C([2H])([2H])C([2H])([2H])N4C([2H])([2H])[2H])=NC2=C1
Synonyms

HF 1854-d₁₁; ZINC000019796155-d₁₁
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.