Clozapine-d11
Clozapine-d11 (HF 1854-d11) is the deuterium labeled Clozapine (HY-14539). Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50 = 11 nM).
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- CAS No.: 1233341-42-8
- Formule: C18H8D11ClN4
- Masse moléculaire:337.89
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1233341-42-8
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Unlabeled Cas 5786-21-0
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Masse moléculaire 337.89
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Formule C18H8D11ClN4
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SMILES
ClC1=CC=C2NC3=CC=CC=C3C(N(C([2H])([2H])C4([2H])[2H])C([2H])([2H])C([2H])([2H])N4C([2H])([2H])[2H])=NC2=C1
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Synonyms
HF 1854-d11; ZINC000019796155-d11
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Clozapine-d11 Related Classifications
HY-14539S5 Related Classifications
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