IKZF3 - IKAROS family zinc finger 3 Gene

Also Known as AIO; IMD84; AIOLOS; ZNFN1A3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22806

About IKZF3

Cytogenetic location: 17q12-q21.1 Genomic coordinates (GRCh38): 17:39,757,715-39,864,312 (from NCBI)

This gene has 17 transcripts (splice variants), 133 orthologues, 11 paralogues and is associated with 71 phenotypes. Biased expression in lymph node (RPKM 17.4), spleen (RPKM 11.5) and 10 other tissues.

Summary

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

IKZF3 Products (16)

mRNA	Protein	Name
NM_001257408.2	NP_001244337.1	zinc finger protein Aiolos isoform 7
NM_001257409.2	NP_001244338.1	zinc finger protein Aiolos isoform 8
NM_001257410.2	NP_001244339.1	zinc finger protein Aiolos isoform 9
NM_001257411.2	NP_001244340.1	zinc finger protein Aiolos isoform 10
NM_001257412.2	NP_001244341.1	zinc finger protein Aiolos isoform 11
NM_001257413.2	NP_001244342.1	zinc finger protein Aiolos isoform 12
NM_001257414.2	NP_001244343.1	zinc finger protein Aiolos isoform 13
NM_001284514.2	NP_001271443.1	zinc finger protein Aiolos isoform 14
NM_001284515.2	NP_001271444.1	zinc finger protein Aiolos isoform 14
NM_001284516.1	NP_001271445.1	zinc finger protein Aiolos isoform 14
NM_012481.5	NP_036613.2	zinc finger protein Aiolos isoform 1
NM_183228.3	NP_899051.1	zinc finger protein Aiolos isoform 2
NM_183229.3	NP_899052.1	zinc finger protein Aiolos isoform 3
NM_183230.3	NP_899053.1	zinc finger protein Aiolos isoform 4
NM_183231.3	NP_899054.1	zinc finger protein Aiolos isoform 5
NM_183232.3	NP_899055.1	zinc finger protein Aiolos isoform 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	34155405	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	17646674	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	17646674	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10369681	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	34155405	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17646674	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	34155405	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10369681	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10369681	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10369681	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IKZF3 Protein Structure

zf-H2C2_2

0
100
200
300
400
509 a.a.

Protein Preferred Names	Protein Names
zinc finger protein Aiolos	zinc finger DNA binding protein Aiolos

IKZF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IKZF3	Q9UKT9	FBF1	Homo sapiens	Q8TES7-6	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	FBF1	Homo sapiens	Q8TES7-6	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	POLM	Homo sapiens	Q6PIY2	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	POLM	Homo sapiens	Q6PIY2	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	LGALS14	Homo sapiens	Q8TCE9	Y2H Array	31515488
Intra	IKZF3	Q9UKT9	LGALS14	Homo sapiens	Q8TCE9	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	LGALS14	Homo sapiens	Q8TCE9	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	OAZ3	Homo sapiens	Q9UMX2	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	27107012
Intra	IKZF3	Q9UKT9	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	31515488
Intra	IKZF3	Q9UKT9	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	CABP5	Homo sapiens	Q9NP86	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	BCAS2	Homo sapiens	O75934	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	BCAS2	Homo sapiens	O75934	Y2H Array	31515488
Intra	IKZF3	Q9UKT9	BCAS2	Homo sapiens	O75934	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	BCAS2	Homo sapiens	O75934	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	PCID2	Homo sapiens	Q5JVF3	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	PCID2	Homo sapiens	Q5JVF3	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	PRKAB2	Homo sapiens	O43741	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	PRKAB2	Homo sapiens	O43741	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	PRKAB2	Homo sapiens	O43741	Validated Y2H	27107012
Intra	IKZF3	Q9UKT9	PRKAB2	Homo sapiens	O43741	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	POLR1C	Homo sapiens	O15160	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	POLR1C	Homo sapiens	O15160	Validated Y2H	27107012
Intra	IKZF3	Q9UKT9	POLR1C	Homo sapiens	O15160	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	RAD51D	Homo sapiens	O75771	Y2H Array	31515488
Intra	IKZF3	Q9UKT9	RAD51D	Homo sapiens	O75771	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	RAD51D	Homo sapiens	O75771	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	IKZF3	Q9UKT9	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	IKZF3	Q9UKT9	ATPAF2	Homo sapiens	Q8N5M1	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	ATPAF2	Homo sapiens	Q8N5M1	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	ATPAF2	Homo sapiens	Q8N5M1	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	ATPAF2	Homo sapiens	Q8N5M1	Y2H	21516116
Intra	IKZF3	Q9UKT9	PRKAA1	Homo sapiens	Q13131	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	PRKAA1	Homo sapiens	Q13131	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	IKZF3	Q9UKT9	IKZF4	Homo sapiens	Q9H2S9	Anti Tag CoIP	33961781
Intra	IKZF3	Q9UKT9	CHCHD2	Homo sapiens	Q9Y6H1	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	CHCHD2	Homo sapiens	Q9Y6H1	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	FANCL	Homo sapiens	Q9NW38	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	FANCL	Homo sapiens	Q9NW38	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	FANCL	Homo sapiens	Q9NW38	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	IKZF3	Q9UKT9	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	IKZF3	Q9UKT9	ZMYM2	Homo sapiens	Q9UBW7	Y2H Prey Pooling	32296183
Intra	IKZF3	Q9UKT9	ZMYM2	Homo sapiens	Q9UBW7	Y2H Array	32296183
Intra	IKZF3	Q9UKT9	CDK4	Homo sapiens	P11802	Y2H Prey Pooling	32296183
Intra	IKZF3	Q9UKT9	CDK4	Homo sapiens	P11802	Y2H Array	32296183
Intra	IKZF3	Q9UKT9	ZGPAT	Homo sapiens	Q8N5A5	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	PIK3R2	Homo sapiens	O00459	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	PIK3R2	Homo sapiens	O00459	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	ABLIM3	Homo sapiens	O94929	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	PFDN5	Homo sapiens	Q99471	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	IKZF3	Q9UKT9	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	IKZF3	Q9UKT9	EMC2	Homo sapiens	Q15006	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	EMC2	Homo sapiens	Q15006	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	EXOSC5	Homo sapiens	Q9NQT4	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	EXOSC5	Homo sapiens	Q9NQT4	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	CDKN1A	Homo sapiens	P38936	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	CDKN1A	Homo sapiens	P38936	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	TSSK3	Homo sapiens	Q96PN8	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	TSSK3	Homo sapiens	Q96PN8	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	KAT5	Homo sapiens	Q92993	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	KAT5	Homo sapiens	Q92993	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	KAT5	Homo sapiens	Q92993	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	GRB2	Homo sapiens	P62993	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	GRB2	Homo sapiens	P62993	Validated Y2H	27107012
Intra	IKZF3	Q9UKT9	RHOA	Homo sapiens	P61586	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	ING5	Homo sapiens	Q8WYH8	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	ING5	Homo sapiens	Q8WYH8	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	TRIM42	Homo sapiens	Q8IWZ5	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	PIN1	Homo sapiens	Q13526	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	NEK6	Homo sapiens	Q9HC98	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	NEK6	Homo sapiens	Q9HC98	Y2H Array	29892012
Intra	IKZF3	Q9UKT9	EXOC8	Homo sapiens	Q8IYI6	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	EXOC8	Homo sapiens	Q8IYI6	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	KRT19	Homo sapiens	P08727	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	FAM50B	Homo sapiens	Q9Y247	Validated Y2H	32296183
Intra	IKZF3	Q9UKT9	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	27107012
Intra	IKZF3	Q9UKT9	ARMC7	Homo sapiens	Q9H6L4	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	EFHC1	Homo sapiens	Q5JVL4	Y2H Array	31515488
Intra	IKZF3	Q9UKT9	EFHC1	Homo sapiens	Q5JVL4	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	EFHC1	Homo sapiens	Q5JVL4	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	RCOR3	Homo sapiens	Q9P2K3	Y2H	21516116
Intra	IKZF3	Q9UKT9	TRAPPC6A	Homo sapiens	O75865	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	TRAPPC6A	Homo sapiens	O75865	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	GEM	Homo sapiens	P55040	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	GEM	Homo sapiens	P55040	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	IKZF3	Q9UKT9	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	AQP1	Homo sapiens	P29972	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	AQP1	Homo sapiens	P29972	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	CDKN2D	Homo sapiens	P55273	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	CDKN2D	Homo sapiens	P55273	Y2H	21516116
Intra	IKZF3	Q9UKT9	CDKN2D	Homo sapiens	P55273	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	MAGOHB	Homo sapiens	Q96A72	Y2H	21516116
Intra	IKZF3	Q9UKT9	MAGOHB	Homo sapiens	Q96A72	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	STK16	Homo sapiens	O75716	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	TCAF1	Homo sapiens	Q9Y4C2	Y2H	21516116
Intra	IKZF3	Q9UKT9	TCAF1	Homo sapiens	Q9Y4C2	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	TEKT4	Homo sapiens	Q8WW24	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	TEKT4	Homo sapiens	Q8WW24	Y2H	21516116
Intra	IKZF3	Q9UKT9	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	NATD1	Homo sapiens	Q8N6N6	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	TBC1D22B	Homo sapiens	Q9NU19	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	29892012
Intra	IKZF3	Q9UKT9	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	31515488
Intra	IKZF3	Q9UKT9	TSTD2	Homo sapiens	Q5T7W7	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	TSTD2	Homo sapiens	Q5T7W7	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	OSGIN1	Homo sapiens	Q9UJX0	Y2H Array	31515488
Intra	IKZF3	Q9UKT9	OSGIN1	Homo sapiens	Q9UJX0	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	AKAP9	Homo sapiens	Q99996-2	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	AKAP9	Homo sapiens	Q99996-2	Validated Y2H	25416956
Intra	IKZF3	Q9UKT9	MORN3	Homo sapiens	Q6PF18	Y2H Prey Pooling	25416956
Intra	IKZF3	Q9UKT9	MORN3	Homo sapiens	Q6PF18	Y2H Array	25416956
Intra	IKZF3	Q9UKT9	FOXP3	Homo sapiens	Q9BZS1	Anti Tag CoIP	20676092

Cross: Cross-species interaction Intra: Intraspecies interaction

IKZF3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82371	IKZF3 Antibody (YA2116)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency 84	IMD84
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Gestational Ovarian Choriocarcinoma
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10984	Pomalidomide	Degrader	99.96%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-144841	Cemsidomide	Degrader	99.54%	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W1135319	SB-405483		99.33%	Unkown
HY-161101	MG degrader 1	Degrader	99.30%	Unkown
HY-168615	MGD-28	Degrader	99.73%	Unkown
HY-168614	MGD-4	Degrader	/	Unkown
HY-169077	IKZF3 degrader 1	Degrader	/	Unkown
HY-179075	PROTAC BCL6/IKZF1/3 Degrader-1	Degrader	/	Unkown
HY-182797	NHWL071065	Degrader	/	Unkown
HY-175600	MI-2-80	Degrader	/	Unkown
HY-175602	TM-04-064-02	Degrader	/	Unkown
HY-175040	PROTAC FLT-3 degrader 5	Degrader	/	Unkown
HY-180836	DIX-01	Degrader	/	Unkown
HY-181651	SZU305	Inhibitor	/	Unkown
HY-179077	PROTAC BTK/IKZF1/3 Degrader-1	Degrader	/	Unkown
HY-179076	BTK/IKZF1/3 ligand 1	Ligand	/	Unkown
HY-175502	MGD-22	Degrader	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IKZF3	RGD	RGD:1307024
Felis catus	IKZF3	VGNC	VGNC:62900
Canis familiaris	IKZF3	VGNC	VGNC:41925
Mus musculus	IKZF3	MGD	MGI:1342542
Macaca mulatta	IKZF3	VGNC	VGNC:73587
Bos taurus	IKZF3	VGNC	VGNC:30104
Others	IKZF3	NCBI