DS-103
DS-103 is an inhibitor for HDAC that inhibits HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8 with IC50s of 0.029, 0.123, 0.022, 0.367 and 9.26 μM, respectively. DS-103 inhibits Plasmodium falciparum 3D7 with IC50 of 5.08 μM. DS-103 exhibits cytotoxicity in cells A2780 and Cal27 with IC50 of 1.48 μM and 1.47 μM, reverses Cisplatin (HY-17394) resistance in A2780 and Cal27 with IC50 of 4.62 μM and 2.23 μM. DS-103 exhibits synergistic effect with Cisplatin (HY-17394), enhances Cisplatin-induced apoptosis.
For research use only. We do not sell to patients.
- Formula: C28H33N5O3
- Molecular Weight:487.59
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Parasite Isoforms
More
Biological Activity
|
HDAC3 0.022 μM (IC50) |
HDAC1 0.029 μM (IC50) |
HDAC2 0.123 μM (IC50) |
HDAC6 0.367 μM (IC50) |
HDAC8 9.26 μM (IC50) |
Chemical Information
-
Molecular Weight 487.59
-
Formula C28H33N5O3
-
SMILES
O=C(N(CC1=CC=C(C=C1)C(NNCC)=O)CC(NCC2=CC=CC=C2)=O)C3=CC=C(C=C3)N(C)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DS-103 Related Classifications
HY-173064 Related Classifications
Powered by Bioz