CST651
CST651 (PROTAC CDK4/6 degrader 34) is a selective cyclin dependent kinase CDK4/6 PROTAC degrader. CST651 can degrade CDK4 and CDK6 in MM.1S cells with DC50 values of 20 and 5.1 nM. CST651 can inhibit cancer cells proliferation and migration. CST651 can be used for the research of cancer, such as acute lymphoblastic leukemia.
(Pink: Cdk4/cyclin D3 and Cdk4/cyclin D1 and Cdk6/cyclin D2 ligand (HY-50767); Blue: VHL ligand (HY-125905); Black: linker (HY-W017440)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2489241-16-7
- Fòrmula: C56H72FN11O9S
- Peso molecular:1094.30
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas PROTACs
More
Actividad biológica
|
CDK6 5.1 nM (DC50, In MM.1S cells) |
CDK4 20 nM (DC50, In MM.1S cells) |
VHL |
Chemical Information
-
No. CAS 2489241-16-7
-
Peso molecular 1094.30
-
Fòrmula C56H72FN11O9S
-
SMILES
O=C1C(C(C)=O)=C(C2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCN(CCOCCOCCOC6=CC(C7=C(C)N=CS7)=CC=C6CNC([C@H]8N(C([C@H](C(C)(C)C)NC(C9(CC9)F)=O)=O)C[C@H](O)C8)=O)CC5)C=N4)C
-
Synonyms
PROTAC CDK4/6 degrader 34
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CST651 Related Classifications
HY-134303 Related Classifications
Powered by Bioz