Melafolone
Melafolone is a potent dual COX-2/EGFR inhibitor with IC50s of 13.2 μM (COX-2) and 17.4 μM (EGFR). Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research.
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- No. CAS: 129724-42-1
- Fòrmula: C22H24O7
- Peso molecular:400.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
COX-2 13.2 μM (IC50) |
EGFR 17.4 μM (IC50) |
Chemical Information
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No. CAS 129724-42-1
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Peso molecular 400.42
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Fòrmula C22H24O7
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SMILES
O=C(C1=C(C(OC(C(C)CC)=O)=C(C(OC)=C1O)O)OC)/C=C/C2=CC=CC=C2
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Melafolone Related Classifications
HY-165394 Related Classifications
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