Hmgb1 - high mobility group box 1 Gene

Also Known as p30; Hmg1; HMG-1; SBP-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15289

Summary

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

Hmgb1 Products (2)

mRNA Protein Name
NM_001313894.1 NP_001300823.1 high mobility group protein B1
NM_010439.4 NP_034569.1 high mobility group protein B1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent protein kinase regulator activity IDA
IDA: Inferred from direct assay
7741753 MGI
enables cytokine activity IDA
IDA: Inferred from direct assay
7635200 MGI
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
19890330 MGI
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
19890330 MGI
enables nucleic acid binding EXP
EXP: Inferred from Experiment
15379539 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11099378 MGI
enables protein kinase activator activity IDA
IDA: Inferred from direct assay
7741753 MGI
enables single-stranded RNA binding IDA
IDA: Inferred from direct assay
19890330 MGI
Biological Process GO Annotation Evidence References Source
involved in base-excision repair IMP
IMP: Inferred from mutant phenotype
17803946 MGI
acts upstream of or within cellular response to interleukin-7 IDA
IDA: Inferred from direct assay
29581031 MGI
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
28096568 MGI
involved in chromatin organization IDA
IDA: Inferred from direct assay
18650382 MGI
involved in endothelial cell chemotaxis IDA
IDA: Inferred from direct assay
16365390 MGI
involved in endothelial cell proliferation IDA
IDA: Inferred from direct assay
16365390 MGI
acts upstream of or within eye development IMP
IMP: Inferred from mutant phenotype
10391216 MGI
acts upstream of glycogen catabolic process IMP
IMP: Inferred from mutant phenotype
10391216 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
10391216 MGI
involved in macrophage activation involved in immune response IMP
IMP: Inferred from mutant phenotype
19890330 MGI
acts upstream of myeloid cell differentiation IDA
IDA: Inferred from direct assay
7635200 MGI
involved in myeloid dendritic cell activation IMP
IMP: Inferred from mutant phenotype
19890330 MGI
acts upstream of myeloid progenitor cell differentiation IDA
IDA: Inferred from direct assay
7635200 MGI
involved in plasmacytoid dendritic cell activation IMP
IMP: Inferred from mutant phenotype
19890330 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
16365390 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
20819940 MGI
acts upstream of or within positive regulation of glycogen catabolic process IMP
IMP: Inferred from mutant phenotype
10391216 MGI
involved in positive regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
19890330 MGI
involved in positive regulation of interferon-alpha production IMP
IMP: Inferred from mutant phenotype
19890330 MGI
involved in positive regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
19890330 MGI
involved in positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
19890330 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
19264983 MGI
involved in positive regulation of monocyte chemotactic protein-1 production IMP
IMP: Inferred from mutant phenotype
19264983 MGI
acts upstream of or within positive regulation of myeloid cell differentiation IDA
IDA: Inferred from direct assay
7635200 MGI
acts upstream of or within positive regulation of myeloid progenitor cell differentiation IDA
IDA: Inferred from direct assay
7635200 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
16267105 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
7741753 MGI
involved in positive regulation of sprouting angiogenesis IDA
IDA: Inferred from direct assay
16365390 MGI
involved in positive regulation of toll-like receptor 2 signaling pathway IDA
IDA: Inferred from direct assay
16267105 MGI
involved in positive regulation of toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
16267105 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10391216 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
19264983 MGI
involved in positive regulation of wound healing IDA
IDA: Inferred from direct assay
16365390 MGI
involved in regulation of T cell mediated immune response to tumor cell IDA
IDA: Inferred from direct assay
23108142 MGI
involved in regulation of nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
18650382 MGI
involved in regulation of tolerance induction IMP
IMP: Inferred from mutant phenotype
18631454 MGI
acts upstream of or within response to glucocorticoid IMP
IMP: Inferred from mutant phenotype
10391216 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10391216 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9767109 MGI
located in early endosome IDA
IDA: Inferred from direct assay
19890330 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
7635200 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
12609598 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9767109 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high mobility group protein B1

  • amphoterin

  • high mobility group protein 1

Recombinant Hmgb1 Proteins

Cat. No. Product Name Accession Purity
HY-P73104 HMGB1/HMG-1 Protein, Mouse (HEK293, Fc, solution) P63158 (M1-E215) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73104A HMGB1/HMG-1 Protein, Mouse (HEK293, Fc) P63158 (M1-E215) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P700182AF Animal-Free HMGB1/HMG-1 Protein, Mouse (His) P63158 (M1-E215) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14519 Methotrexate Inhibitor 99.95% Yes
HY-N0184 Glycyrrhizic acid Inhibitor 99.84% Yes
HY-B0581 Dexrazoxane 99.88% Yes
HY-14519A Methotrexate disodium Inhibitor 99.63% Yes
HY-N0184A Dipotassium glycyrrhizinate Inhibitor 99.68% Yes
HY-14519B Methotrexate hydrate Inhibitor 99.66% Unkown
HY-N0184R Glycyrrhizic acid (Standard) Inhibitor 97.54% Unkown
HY-14519D Methotrexate monohydrate Inhibitor / Unkown
HY-121151 (±)-Methotrexate Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9928 Alirocumab Inhibitor 97.00% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-Y1362 Ethyl pyruvate 99.87% Phase 4
HY-10447 Terameprocol 99.50% Phase 2
HY-113402B Gamma-glutamylcysteine ammonium / Phase 1

Pre-clinical Phase

Bioactive Molecules (55)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101872 GSK-872 Inhibitor 99.91% Unkown
HY-113402 Gamma-glutamylcysteine 98.53% Unkown
HY-14307 Necrocide 1 99.55% Unkown
HY-101872A GSK-872 hydrochloride Inhibitor 98.85% Unkown
HY-111815A N4-Acetylcytidine triphosphate sodium solution (100 mM) / Unkown
HY-P2268 RAGE antagonist peptide Antagonist 98.16% Unkown
HY-162065 N6F11 Inducer 98.11% Unkown
HY-W019670 N4-Acetylcytidine 99.65% Unkown
HY-N0535 (+)-Magnoflorine chloride 99.29% Unkown
HY-148226 20-5,14-HEDGE 99.28% Unkown
HY-P3042 Chymostatin Inhibitor 99.9% Unkown
HY-113772 Inflachromene Inhibitor 99.76% Unkown
HY-N0334A (+)-Magnoflorine iodide 99.74% Unkown
HY-113402A Gamma-glutamylcysteine TFA 96.68% Unkown
HY-N0442 5-O-Methylvisammioside Inhibitor 99.90% Unkown
HY-124750 NecroX-7 Inhibitor 99.69% Unkown
HY-N1508 Ecliptasaponin A 99.81% Unkown
HY-N2055 Kaempferol 3-O-sophoroside 99.41% Unkown
HY-W017180 2-(Bromomethyl)acrylic acid 97.51% Unkown
HY-14519S Methotrexate-d3 Inhibitor 99.83% Unkown
HY-P2268A RAGE antagonist peptide TFA Antagonist 99.41% Unkown
HY-172279A DSPE-PEG2000-TAT 95.0% Unkown
HY-155751 HMGB1-IN-1 Inhibitor 98.40% Unkown
HY-113402R Gamma-glutamylcysteine (Standard) 98.14% Unkown
HY-N0772 Isomangiferin 99.60% Unkown
HY-163409 CGK012 Inhibitor 99.96% Unkown
HY-N0320 Salvianolic acid D 95.15% Unkown
HY-RS06232 HMGB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N3097 Pellitorine 99.84% Unkown
HY-W753593 N4-Acetylcytidine-13C5 95.92% Unkown
HY-111815 N4-Acetylcytidine triphosphate / Unkown
HY-14519S1 Methotrexate-d3 diammonium Inhibitor 99.69% Unkown
HY-113402AR Gamma-glutamylcysteine TFA (Standard) 95.17% Unkown
HY-N0334 (+)-Magnoflorine / Unkown
HY-121151S (±)-Methotrexate-d3 Inhibitor / Unkown
HY-121151S2 (±)-Methotrexate-13C,d3 disodium Inhibitor / Unkown
HY-143456 Anti-inflammatory agent 18 Inhibitor / Unkown
HY-143457 Anti-inflammatory agent 19 Inhibitor / Unkown
HY-155759 HMGB1-IN-2 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-184943 Pan-PDK degrader-1 / Unkown
HY-19421 Orazamide Inhibitor / Unkown
HY-N9587 Tricin 7-O-β-D-glucopyranoside Inducer 99.23% Unkown
HY-P10321 HBP08 / Unkown
HY-P11549 pPB peptide Ligand / Unkown
HY-P5762A Phoenixin-14 TFA / Unkown
HY-110051 DPP4-In hydrochloride / Unkown
HY-167182 PUMAi Inhibitor / Unkown
HY-168053 HMGB1-IN-3 Inhibitor / Unkown
HY-182824 Sucrose dilaurate Inducer / Unkown
HY-N0442R 5-O-Methylvisammioside (Standard) Inhibitor / Unkown
HY-N20719 Vulgarin Inhibitor / Unkown
HY-RS16500 Hmgb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22930 Hmgb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25102 Hbp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990117 Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) Inhibitor 95.00% Unkown
HY-P9928A Alirocumab (anti-PCSK9) Inhibitor 98.24% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgb1 NCBI NCBI:3146