HMGB1 - high mobility group box 1 Gene

Also Known as HMG1; HMG3; HMG-1; SBP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3146

About HMGB1

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:30,456,704-30,617,597 (from NCBI)

This gene has 8 transcripts (splice variants), 250 orthologues, 20 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 98.7), lymph node (RPKM 87.4) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

HMGB1 Products (7)

mRNA	Protein	Name
NM_001313892.2	NP_001300821.1	high mobility group protein B1 isoform 1
NM_001313893.1	NP_001300822.1	high mobility group protein B1 isoform 1
NM_001363661.2	NP_001350590.1	high mobility group protein B1 isoform 2
NM_001370339.1	NP_001357268.1	high mobility group protein B1 isoform 2
NM_001370340.1	NP_001357269.1	high mobility group protein B1 isoform 1
NM_001370341.1	NP_001357270.1	high mobility group protein B1 isoform 1
NM_002128.7	NP_002119.1	high mobility group protein B1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C-X-C chemokine binding	IDA IDA: Inferred from direct assay	22370717	GOA
enables DNA binding, bending	IMP IMP: Inferred from mutant phenotype	19223331	GOA
enables DNA polymerase binding	IDA IDA: Inferred from direct assay	17803946	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19223331	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19223331	GOA
enables damaged DNA binding	IDA IDA: Inferred from direct assay	17803946	GOA
enables integrin binding	IDA IDA: Inferred from direct assay	20826760	GOA
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	21660935	GOA
enables lyase activity	IDA IDA: Inferred from direct assay	17803946	GOA
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	18768881	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8006019	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	17568691	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19158276	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	19223331	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	11748232	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T-helper 1 cell activation	IDA IDA: Inferred from direct assay	22473704	GOA
involved in T-helper 1 cell differentiation	IMP IMP: Inferred from mutant phenotype	15944249	GOA
involved in V(D)J recombination	IDA IDA: Inferred from direct assay	9166431	GOA
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	24971542	GOA
involved in apoptotic cell clearance	IDA IDA: Inferred from direct assay	18768881	GOA
involved in heterochromatin formation	IGI IGI: Inferred from genetic interaction	19158276	GOA
involved in inflammatory response	IDA IDA: Inferred from direct assay	23146691	GOA
involved in inflammatory response to antigenic stimulus	IEP IEP: Inferred from expression pattern	19841752	GOA
involved in negative regulation of CD4-positive, alpha-beta T cell differentiation	IDA IDA: Inferred from direct assay	22473704	GOA
involved in negative regulation of RNA polymerase II transcription preinitiation complex assembly	IDA IDA: Inferred from direct assay	8006019	GOA
involved in negative regulation of apoptotic cell clearance	IDA IDA: Inferred from direct assay	20826760	GOA
involved in negative regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	23148224	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11748232	GOA
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19158276	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19158276	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	22473704	GOA
involved in neutrophil clearance	IDA IDA: Inferred from direct assay	18768881	GOA
involved in positive regulation of DNA binding	IDA IDA: Inferred from direct assay	11748232	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	22370717	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	12765338	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	12765338	GOA
involved in positive regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	15944249	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	19800306	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	20819940	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	28276476	GOA
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production	IDA IDA: Inferred from direct assay	26961863	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	19800306	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	22370717	GOA
involved in positive regulation of dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	15944249	GOA
involved in positive regulation of interleukin-1 production	IDA IDA: Inferred from direct assay	12765338	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	22473704	GOA
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	15944249	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	12765338	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	26961863	GOA
involved in positive regulation of mismatch repair	IDA IDA: Inferred from direct assay	15014079	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: Inferred from direct assay	22370717	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19223331	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	12765338	GOA
involved in positive regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	28276476	GOA
involved in positive regulation of viral entry into host cell	IMP IMP: Inferred from mutant phenotype	33147444	GOA
involved in regulation of restriction endodeoxyribonuclease activity	IDA IDA: Inferred from direct assay	17803946	GOA
involved in regulation of tolerance induction	IDA IDA: Inferred from direct assay	18631454	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of alphav-beta3 integrin-HMGB1 complex	IDA IDA: Inferred from direct assay	20826760	GOA
located in cell surface	IDA IDA: Inferred from direct assay	19841752	GOA
located in condensed chromosome	IDA IDA: Inferred from direct assay	12925773	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	35239449	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	25595774	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	19841752	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8339930	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	19158276	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMGB1 Protein Structure

HMG_box_2

HMG_box

0
100
200
215 a.a.

Protein Preferred Names	Protein Names
high mobility group protein B1	Amphoterin

HMGB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HMGB1	P09429	AGER	Homo sapiens	Q15109	SPR	24474694
Intra	HMGB1	P09429	KRT7	Homo sapiens	P08729	Y2H	31694235
Intra	HMGB1	P09429	KRT7	Homo sapiens	P08729	Y2H	29721183
Intra	HMGB1	P09429	KRT7	Homo sapiens	P08729	Y2H	32867128
Intra	HMGB1	P09429	KRT7	Homo sapiens	P08729	Confocal	31694235
Intra	HMGB1	P09429	KRT7	Homo sapiens	P08729	Anti Bait CoIP	31694235
Intra	HMGB1	P09429	HNRNPU	Homo sapiens	Q00839	Anti Bait CoIP	31694235
Intra	HMGB1	P09429	HNRNPU	Homo sapiens	Q00839	Y2H	31694235
Intra	HMGB1	P09429	HNRNPU	Homo sapiens	Q00839	Anti Bait CoIP	29721183
Intra	HMGB1	P09429	PARP1	Homo sapiens	P09874	Anti Bait CoIP	29721183
Intra	HMGB1	P09429	MSH2	Homo sapiens	P43246	Anti Bait CoIP	15014079
Intra	HMGB1	P09429	TP53	Homo sapiens	P04637	Crosslink	23063560
Intra	HMGB1	P09429	TP53	Homo sapiens	P04637	ITC	23063560
Intra	HMGB1	P09429	TP53	Homo sapiens	P04637	Far-WB	9472015
Intra	HMGB1	P09429	TP53	Homo sapiens	P04637	GMS	23063560
Intra	HMGB1	P09429	TP53	Homo sapiens	P04637	NMR	23063560
Intra	HMGB1	P09429	SRSF3	Homo sapiens	P84103	Anti Bait CoIP	29721183
Intra	HMGB1	P09429	SRSF3	Homo sapiens	P84103	Anti Bait CoIP	31694235
Intra	HMGB1	P09429	SRSF3	Homo sapiens	P84103	Y2H	31694235
Intra	HMGB1	P09429	HTT	Homo sapiens	P42858	PLA	23303669
Intra	HMGB1	P09429	HTT	Homo sapiens	P42858	Anti Tag CoIP	23303669
Intra	HMGB1	P09429	HTT	Homo sapiens	P42858	Confocal	23303669
Intra	HMGB1	P09429	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	32296183
Intra	HMGB1	P09429	CCNDBP1	Homo sapiens	O95273	Y2H Array	32296183
Intra	HMGB1	P09429	RSF1	Homo sapiens	Q96T23	Y2H	32867128
Intra	HMGB1	P09429	RSF1	Homo sapiens	Q96T23	Anti Bait CoIP	29721183
Intra	HMGB1	P09429	RSF1	Homo sapiens	Q96T23	Y2H	31694235
Intra	HMGB1	P09429	BECN1	Homo sapiens	Q14457	Anti Bait CoIP	20819940
Intra	HMGB1	P09429	ZNF428	Homo sapiens	Q96B54	Y2H	31694235

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HMGB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70274	HMGB1/HMG-1 Protein, Human (HEK293, His, solution)	P09429 (G2-E215)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70570	HMGB1/HMG-1 Protein, Human	P09429 (M1-F89)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72797	HMGB1/HMG-1 Protein, Human (His)	P09429 (M1-E215)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73103	HMGB1/HMG-1 Protein, Human (102a.a, His)	P09429 (K57-D158)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73102	HMGB1/HMG-1 Protein, Human (HEK293, Fc)	P09429/NP_002119.1 (M1-E215)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78139	HMGB1/HMG-1 Protein, Human (Biotinylated, HEK293, His)	P09429 (M1-E215)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P72797AF	Animal-Free HMGB1/HMG-1 Protein, Human (His)	P09429 (M1-E215)	≥ 95%, as determined by reducing SDS-PAGE.

HMGB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80183	HMGB1 Antibody (YA361)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
HY-P85867	HMGB1 Antibody (YA5559)	WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86393	HMGB1 Antibody (YA6085)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Endophthalmitis
Borna Disease	Enzootic Encephalomyelitis
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Malignant Pleural Mesothelioma	Malignant Mesothelioma Of Pleura Pleural Malignant Mesothelioma
Synovitis
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Disseminated Intravascular Coagulation	Defibrination Syndrome Dic Diffuse Or Disseminated Intravascular Coagulation Fibrinolytic Purpura Consumption Coagulopathy Diffuse Intravascular Coagulation Dic - [Disseminated Intravascular Coagulation] Disseminated Intravascular Coagulopathy Fibrinolysis Nos Thrombolytic Purpura
Chorioamnionitis
Cardiac Arrest	Cardiopulmonary Arrest Circulatory Arrest Heart Arrest
Churg-Strauss Syndrome	Eosinophilic Granulomatosis With Polyangiitis Allergic Granulomatous Angiitis Churg-Strauss Vasculitis Allergic Angiitis Egpa Granulomatous Allergic Angiitis Allergic Granulomatosis Angiitis Allergic Angiitis And Granulomatosis Allergic Granulomatosis Allergic Granulomatous And Angiitis Css
Autoimmune Hepatitis	Aih Hepatitis, Autoimmune Autoimmune Chronic Active Hepatitis Autoimmune Hepatitis With Centrilobular Necrosis Autoimmune Chronic Hepatitis Hepatitis Autoimmune
Mouth Disease	Mouth Diseases Mouth Disorders
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Pituitary Apoplexy	Pituitary Tumor Apoplexy
Silicosis	Silicotuberculosis Acute Silicosis Chronic Silicosis Pneumoconiosis Due To Silicates Silica Pneumoconiosis Silicotic Fibrosis Of Lung Accelerated Silicosis Experimental Silicosis
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Melioidosis	Melioidosis, Susceptibility To Acute And Fulminating Melioidosis Nightcliff Gardener'S Disease Pseudoglanders Subacute And Chronic Melioidosis Burkholderia Pseudomallei Infection Whitmore Disease Whitmore'S Disease B Pseudomallei Infection Epizootic Lymphangitis Infection Due To Burkholderia Pseudomallei Infection Due To Burkholderia Pseudomallei Nos Infection Due To Malleomyces Pseudomallei Infection Due To Pseudomonas Pseudomallei Infection Due To Pseudomonas Pseudomallei Nos Infection Due To Whitmore Bacillus Stanton Disease
Appendicitis	Acute Appendicitis Acute Appendicitis With Generalized Peritonitis Acute Appendicitis Nos Acute Appendicitis With Peritoneal Abscess Appendiceal Inflammation Appendicitis, Unqualified Acute Appendix Inflammation Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation Acute Appendicitis With Free Peritonitis Acute Appendicitis With Free Perforation To The Abdominal Cavity Perforated Appendix With Generalised Peritonitis Appendicitis With Perforation And Free Pus In The Peritoneal Cavity Perforated Appendix With Localised Peritonitis Acute Appendicitis With Contained Perforation To A Localised Abscess Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess Appendicitis With Abscess Appendicitis With Peritoneal Abscess Ruptured Appendix Nos Acute Appendicitis With No Perforation Or Abscess And No Visible Pus Acute Appendicitis With No Specification If Perforated Or Not Acute Appendicitis With Phlegmone
Mucositis	Inflammatory Disease Of Mucous Membrane Gastrointestinal Mucositis
Enterocolitis
Peritonitis	Retractile Mesenteritis Sclerosing Mesenteritis Acute Generalized Peritonitis Primary Bacterial Peritonitis Idiopathic Sclerosing Mesenteritis Mesenteric Panniculitis Peritoneal Retractile Mesenteritis Liposclerotic Mesenteritis Mesenteric Fibromatosis Mesenteric Lipodystrophy Mesenteric Lipogranuloma Fibromatosis, Abdominal Peritoneum Inflammation Peritonitis Of Undetermined Cause Peritonitis Of Unspecified Cause Pelviperitonitis Pelvic Peritonitis, Nos Generalised Peritonitis Nos Abdominal Peritonitis Acute Idiopathic Peritonitis Acute Lesser Sac Peritonitis Acute Peritoneal Inflammation Diffuse Peritonitis Peritoneal Inflammation Acute Primary Peritonitis Pneumococcal Peritonitis
Thrombophilia	Hypercoagulability State
Toxic Shock Syndrome	Septic Shock Toxic Shock Tss Shock, Septic Staphylococcal Toxic Shock Syndrome Tss - [Toxic Shock Syndrome]
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Post-Cardiac Arrest Syndrome	Post Cardiac Syndrome
Retinal Detachment	Retinal Detachments Rhegmatogenous Retinal Detachment Ruptured Retina With Detachment Retinal Hole With Detachment
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Deafness, Autosomal Recessive 74	DFNB74 Autosomal Recessive Nonsyndromic Deafness 74 Autosomal Recessive Deafness 74 Deafness, Autosomal Recessive, 74 Deafness, Autosomal Recessive, Type 74
Bacterial Sepsis
Cardiomyopathy, Familial Hypertrophic, 6	Hypertrophic Cardiomyopathy 6 CMH6 Familial Hypertrophic Cardiomyopathy With Wolff-Parkinson-White Syndrome Cardiomyopathy, Familial Hypertrophic 6 Cardiomyopathy, Hypertrophic 6 Cardiomyopathy, Hypertrophic, Familial, Type 6
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Abacavir Allergy	Abc Allergy
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Preterm Premature Rupture Of The Membranes	Preterm Premature Rupture Of Membranes PPROM Preterm Premature Rupture Of The Membranes, Susceptibility To Pprom - [Preterm Premature Rupture Of Membranes] Preterm Rupture Of Membranes
Diabetes Mellitus	Diabetes
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Purulent Acute Otitis Media	Acute Suppurative Otitis Media Acute Or Subacute Suppurative Otitis Media Acute Or Subacute Purulent Otitis Media
Intracranial Berry Aneurysm	Familial Aneurysmal Subarachnoid Hemorrhage Familial Berry Aneurysm Familial Intracranial Saccular Aneurysm Saccular Cerebral Aneurysm Aneurysm, Intracranial Berry Aneurysmal Subarachnoid Hemorrhage Aneurysm, Intracranial Berry, 1
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14519	Methotrexate	Inhibitor	99.95%	Yes
HY-N0184	Glycyrrhizic acid	Inhibitor	99.84%	Yes
HY-B0581	Dexrazoxane		99.88%	Yes
HY-14519A	Methotrexate disodium	Inhibitor	99.63%	Yes
HY-N0184A	Dipotassium glycyrrhizinate	Inhibitor	99.68%	Yes
HY-14519B	Methotrexate hydrate	Inhibitor	99.66%	Unkown
HY-N0184R	Glycyrrhizic acid (Standard)	Inhibitor	97.54%	Unkown
HY-14519D	Methotrexate monohydrate	Inhibitor	/	Unkown
HY-121151	(±)-Methotrexate	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9928	Alirocumab	Inhibitor	97.00%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Phase
HY-Y1362	Ethyl pyruvate	99.87%	Phase 4
HY-10447	Terameprocol	99.50%	Phase 2
HY-113402B	Gamma-glutamylcysteine ammonium	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (54)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101872	GSK-872	Inhibitor	99.91%	Unkown
HY-113402	Gamma-glutamylcysteine		98.53%	Unkown
HY-14307	Necrocide 1		99.55%	Unkown
HY-101872A	GSK-872 hydrochloride	Inhibitor	98.85%	Unkown
HY-111815A	N4-Acetylcytidine triphosphate sodium solution (100 mM)		98.04%	Unkown
HY-P2268	RAGE antagonist peptide	Antagonist	98.16%	Unkown
HY-162065	N6F11	Inducer	98.11%	Unkown
HY-W019670	N4-Acetylcytidine		99.65%	Unkown
HY-N0535	(+)-Magnoflorine chloride		99.29%	Unkown
HY-148226	20-5,14-HEDGE		99.28%	Unkown
HY-P3042	Chymostatin	Inhibitor	99.9%	Unkown
HY-113772	Inflachromene	Inhibitor	99.76%	Unkown
HY-N0334A	(+)-Magnoflorine iodide		99.74%	Unkown
HY-113402A	Gamma-glutamylcysteine TFA		96.68%	Unkown
HY-N0442	5-O-Methylvisammioside	Inhibitor	99.90%	Unkown
HY-124750	NecroX-7	Inhibitor	99.69%	Unkown
HY-N1508	Ecliptasaponin A		99.81%	Unkown
HY-N2055	Kaempferol 3-O-sophoroside		99.41%	Unkown
HY-W017180	2-(Bromomethyl)acrylic acid		97.51%	Unkown
HY-14519S	Methotrexate-d3	Inhibitor	99.83%	Unkown
HY-P2268A	RAGE antagonist peptide TFA	Antagonist	99.41%	Unkown
HY-172279A	DSPE-PEG2000-TAT		95.0%	Unkown
HY-155751	HMGB1-IN-1	Inhibitor	98.40%	Unkown
HY-113402R	Gamma-glutamylcysteine (Standard)		98.14%	Unkown
HY-N0772	Isomangiferin		99.60%	Unkown
HY-163409	CGK012	Inhibitor	99.96%	Unkown
HY-N0320	Salvianolic acid D		95.15%	Unkown
HY-RS06232	HMGB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N3097	Pellitorine		99.84%	Unkown
HY-W753593	N4-Acetylcytidine-13C5		95.92%	Unkown
HY-111815	N4-Acetylcytidine triphosphate		/	Unkown
HY-14519S1	Methotrexate-d3 diammonium	Inhibitor	99.69%	Unkown
HY-113402AR	Gamma-glutamylcysteine TFA (Standard)		95.17%	Unkown
HY-N0334	(+)-Magnoflorine		/	Unkown
HY-121151S	(±)-Methotrexate-d3	Inhibitor	/	Unkown
HY-121151S2	(±)-Methotrexate-13C,d3 disodium	Inhibitor	/	Unkown
HY-143456	Anti-inflammatory agent 18	Inhibitor	/	Unkown
HY-143457	Anti-inflammatory agent 19	Inhibitor	/	Unkown
HY-155759	HMGB1-IN-2	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-184943	Pan-PDK degrader-1		/	Unkown
HY-19421	Orazamide	Inhibitor	/	Unkown
HY-N9587	Tricin 7-O-β-D-glucopyranoside	Inducer	99.23%	Unkown
HY-P10321	HBP08		/	Unkown
HY-P5762A	Phoenixin-14 TFA		/	Unkown
HY-110051	DPP4-In hydrochloride		/	Unkown
HY-167182	PUMAi	Inhibitor	/	Unkown
HY-168053	HMGB1-IN-3	Inhibitor	/	Unkown
HY-182824	Sucrose dilaurate	Inducer	/	Unkown
HY-N0442R	5-O-Methylvisammioside (Standard)	Inhibitor	/	Unkown
HY-N20719	Vulgarin	Inhibitor	/	Unkown
HY-RS16500	Hmgb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22930	Hmgb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25102	Hbp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990117	Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10)	Inhibitor	95.00%	Unkown
HY-P9928A	Alirocumab (anti-PCSK9)	Inhibitor	98.24%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HMGB1	VGNC	VGNC:53816
Canis familiaris	HMGB1	VGNC	VGNC:59082
Rattus norvegicus	HMGB1	RGD	RGD:2802
Mus musculus	HMGB1	MGD	MGI:96113