Igf1r - insulin-like growth factor I receptor Gene

Also Known as hyft; CD221; IGF-1R; D930020L01; A330103N21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16001

About Igf1r

Chromosome 7: 67,602,575-67,883,416 forward strand.GRCm39:CM001000.3

This gene has 6 transcripts (splice variants), 276 orthologues, 53 paralogues and is associated with 37 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 1.6), kidney adult (RPKM 1.1) and 27 other tissues.

Summary

Enables insulin-like growth factor binding activity. Involved in several processes, including adrenal gland development; positive regulation of cold-induced thermogenesis; and positive regulation of meiotic cell cycle. Acts upstream of or within several processes, including gland development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney Cancer (multiple); liver disease (multiple); nervous system Cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (Insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Igf1r Products (1)

mRNA Protein Name
NM_010513.3 NP_034643.2 insulin-like growth factor 1 receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables insulin-like growth factor binding IPI
IPI: Inferred from physical interaction
14566968 MGI
enables insulin-like growth factor receptor activity IDA
IDA: Inferred from direct assay
19302825 MGI
enables insulin-like growth factor receptor activity IGI
IGI: Inferred from genetic interaction
33567274 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12771153 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
7799946 MGI
enables protein tyrosine kinase activity IGI
IGI: Inferred from genetic interaction
9024787 MGI
enables protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
12483226 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
18451178 MGI
involved in adrenal gland development IGI
IGI: Inferred from genetic interaction
23300479 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
12101187 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
12904469 MGI
acts upstream of or within cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
21677284 MGI
acts upstream of or within cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
21677284 MGI
acts upstream of or within epidermis development IMP
IMP: Inferred from mutant phenotype
23906066 MGI
acts upstream of or within exocrine pancreas development IMP
IMP: Inferred from mutant phenotype
12101187 MGI
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
29348399 MGI
involved in insulin-like growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
8402901 MGI
involved in insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12483226 MGI
acts upstream of or within male sex determination IMP
IMP: Inferred from mutant phenotype
14628051 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
17662267 MGI
acts upstream of mitotic nuclear division IMP
IMP: Inferred from mutant phenotype
23906066 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
23906066 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
18451178 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
18451178 MGI
acts upstream of or within peptidyl-tyrosine autophosphorylation IDA
IDA: Inferred from direct assay
10100151 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
18451178 MGI
involved in positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
23300479 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
18451178 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
26910308 MGI
involved in positive regulation of developmental growth IMP
IMP: Inferred from mutant phenotype
23300479 MGI
involved in positive regulation of meiotic cell cycle IGI
IGI: Inferred from genetic interaction
23300479 MGI
acts upstream of or within positive regulation of mitotic nuclear division IMP
IMP: Inferred from mutant phenotype
23906066 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
18451178 MGI
involved in postsynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
28683263 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
28683263 MGI
acts upstream of or within prostate gland epithelium morphogenesis IMP
IMP: Inferred from mutant phenotype
18451178 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
18216249 MGI
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
23695157 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
28683263 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28683263 MGI
located in membrane IDA
IDA: Inferred from direct assay
7931420 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18451178 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Igf1r Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (50 - 160)

Furin-like

Furin-like: pfam00757 (174 - 329)

Recep_L_domain

Recep_L_domain: pfam01030 (352 - 467)

FN3

FN3: cd00063 (493 - 606)

FN3

FN3: cd00063 (611 - 655)

FN3

FN3: cd00063 (835 - 924)

PTKc_InsR_like

PTKc_InsR_like: cd05032 (992 - 1269)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1369 a.a.
Protein Preferred Names Protein Names

insulin-like growth factor 1 receptor

  • IGF-I receptor

  • line 186

Recombinant Igf1r Proteins

Cat. No. Product Name Accession Purity
HY-P78723 IGF-I R Protein, Mouse (HEK293, His) Q60751-1 (E31-H936) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15656 Ceritinib Inhibitor 99.95% Yes
HY-15656A Ceritinib dihydrochloride Inhibitor 99.90% Yes
HY-B0025 Voglibose Inhibitor 98.0% Unkown
HY-15656AR Ceritinib dihydrochloride (Standard) Inhibitor / Unkown
HY-15656R Ceritinib (Standard) Inhibitor 99.72% Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99165 Teprotumumab Inhibitor 99.46% Unkown
HY-P990084 Veligrotug 99.25% Unkown

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-15656B Ceritinib mesylate Inhibitor / Phase 4
HY-15494 Picropodophyllin 99.85% Phase 2
HY-10200 BMS-754807 Inhibitor 99.42% Phase 2
HY-19565 KW-2450 tosylate / Phase 2
HY-B0794 AZ7550 Inhibitor 97.09% Phase 1
HY-15749 XL228 Inhibitor 99.64% Phase 1
HY-13326 ASP3026 99.88% Phase 1
HY-113402B Gamma-glutamylcysteine ammonium / Phase 1
Inhibitory Antibodies (8)
Cat. No. Product Name Effect
Purity Phase
HY-P99294 Ganitumab Inhibitor 96.00% Phase 3
HY-P99197 Figitumumab Inhibitor ≥99.0% Phase 3
HY-P99189 Cixutumumab Inhibitor 99.63% Phase 2
HY-P99284 Dalotuzumab 97.43% Phase 2
HY-P99218 Robatumumab Inhibitor 98.00% Phase 2
HY-P99712 Lonigutamab 95.00% Phase 2
HY-P99672 Istiratumab Inhibitor 98.45% Phase 2
HY-P991253 BIIB022 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (65)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113402 Gamma-glutamylcysteine 98.53% Unkown
HY-116624 MAZ51 99.96% Unkown
HY-50866 NVP-AEW541 99.71% Unkown
HY-10262 BMS-536924 99.83% Unkown
HY-15609 AZD-3463 99.31% Unkown
HY-13203 NVP-TAE 226 99.77% Unkown
HY-N7922 Urolithin M5 Inhibitor 97.31% Unkown
HY-10252 NVP-ADW742 99.30% Unkown
HY-10253 AG1024 99.50% Unkown
HY-N0908 Ginsenoside Rg5 99.88% Unkown
HY-10524 GSK1904529A 99.03% Unkown
HY-Y1322 Triphenyl phosphate 99.67% Unkown
HY-113402A Gamma-glutamylcysteine TFA 96.68% Unkown
HY-N1990 Gypenoside XLIX 99.88% Unkown
HY-P5133 Synstatin (92-119) Inhibitor 97.61% Unkown
HY-P3226 JB-1 99.63% Unkown
HY-100349 SU4312 Inhibitor 99.74% Unkown
HY-B0794B AZ7550 Mesylate Inhibitor 98.70% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-135680 I-OMe-Tyrphostin AG 538 Inhibitor 98.03% Unkown
HY-18785 Indirubin Derivative E804 Inhibitor 98.54% Unkown
HY-113402R Gamma-glutamylcysteine (Standard) 98.14% Unkown
HY-145110 IGF-1R inhibitor-2 Inhibitor 98.07% Unkown
HY-156914 IGF-1R/SRC-IN-1 Inhibitor 99.86% Unkown
HY-177760 PrCP-7414 / Unkown
HY-125102 AZ12253801 Inhibitor / Unkown
HY-15656S Ceritinib-d7 Inhibitor 98.00% Unkown
HY-B0794A AZ7550 hydrochloride Inhibitor 98.66% Unkown
HY-113402AR Gamma-glutamylcysteine TFA (Standard) 95.17% Unkown
HY-15494R Picropodophyllin (Standard) 99.70% Unkown
HY-21291 SU-4313 Modulator 99.31% Unkown
HY-B0794S AZ7550-d5 Inhibitor / Unkown
HY-N6611 Chimaphilin Inhibitor 99.80% Unkown
HY-50866B NVP-AEW541 dihydrochloride / Unkown
HY-100038 AZD9362 Inhibitor / Unkown
HY-10252A cis-NVP-ADW742 Inhibitor / Unkown
HY-10438 BMS-577098 Inhibitor / Unkown
HY-108230 ALK-IN-12 Inhibitor / Unkown
HY-116059 EGFR-IN-199 Inhibitor / Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-13312A GTx-134 / Unkown
HY-15494S Picropodophyllin-d3 / Unkown
HY-15494S1 Picropodophyllin-d6 / Unkown
HY-162506 IGF-1R inhibitor-3 Inhibitor / Unkown
HY-167854 KW-2450 free base Inhibitor / Unkown
HY-169572 IGF-1R inhibitor-5 Inhibitor / Unkown
HY-169600 IGF-1R inhibitor-4 Inhibitor / Unkown
HY-17603A (E)-Belizatinib Inhibitor / Unkown
HY-177622 Cibrigirsen Inhibitor / Unkown
HY-177622A Cibrigirsen sodium Inhibitor / Unkown
HY-179732 PROTAC ALK degrader-4 / Unkown
HY-180972 PROTAC EML4-ALK Degrader-2 Inhibitor / Unkown
HY-182264 Masoprocol tetrapivalate Inhibitor / Unkown
HY-183292 SH-1092 Inhibitor / Unkown
HY-402309 IGF-1R modulator 1 Modulator / Unkown
HY-E70730 INSR Recombinant Human Active Protein Kinase / Unkown
HY-RS06615 IGF1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06616 Igf1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06617 Igf1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100349A cis-SU4312 Inhibitor / Unkown
HY-14357 BMS 695735 Inhibitor / Unkown
HY-168616 CL-A3-7 Inhibitor / Unkown
HY-174654 Human IGF1R mRNA / Unkown
HY-174721 Human EGFR mRNA / Unkown
HY-W749516 Voglibose-13C3 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991134 Elegrobart Inhibitor 95.27% Unkown
HY-P991255 VRDN-002 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Igf1r NCBI NCBI:3480