2. Gene
  3. Mmp13 - matrix metallopeptidase 13 Gene

Mmp13 - matrix metallopeptidase 13 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 171052 | Gene type: protein coding

About Mmp13

Primary_assembly 8: 4,497,960-4,508,239 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 203 orthologues, 23 paralogues and is associated with 44 phenotypes. Biased expression in Thymus (RPKM 2.9), Muscle (RPKM 1.6) and 5 other tissues.

Summary

Enables several functions, including fibronectin binding activity; low-density lipoprotein particle receptor binding activity; and metal ion binding activity. Involved in several processes, including animal organ development; embryonic hindlimb morphogenesis; and estrous cycle. Located in several cellular components, including Golgi apparatus; intercellular canaliculus; and lysosome. Used to study brain ischemia; degenerative disc disease; and myocardial infarction. Biomarker of several diseases, including degenerative disc disease; gastric ulcer; liver cirrhosis (multiple); meningococcal meningitis; and silicosis. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); osteoarthritis; ovarian carcinoma; and spondyloepimetaphyseal dysplasia, Missouri type. Orthologous to human MMP13 (matrix metallopeptidase 13). [provided by Alliance of Genome Resources, Apr 2022]

Mmp13 Products(1)

mRNA Protein Name
NM_133530.1 NP_598214.1 collagenase 3 precursor

Mmp13 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (39 - 91)

Peptidase_M10

Peptidase_M10: pfam00413 (112 - 267)

HX

HX: cd00094 (281 - 471)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
Protein Preferred Names Protein Names

collagenase 3

MMP-13

UMRCASE

interstitial collagenase

matrix metalloproteinase-13

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-12170 Prinomastat ≥98.0% Phase 3
HY-12170A Prinomastat hydrochloride 98.18% Phase 3
HY-10398 CTS-1027 Inhibitor 99.19% Phase 2
HY-19485 XL-784 98.13% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99590 Sotatercept 99.61% Phase 3
Pre-clinical Phase
Bioactive Molecules (41)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12270 T-5224 Inhibitor 99.59% Unkown
HY-100359 CL-82198 Inhibitor 99.78% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-N1463 Luteolin 7-O-glucuronide 99.80% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-P4931 Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 99.87% Unkown
HY-107428 PD-166793 Inhibitor 99.45% Unkown
HY-N2350 Cynaropicrin Inhibitor 99.71% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-108672 NF157 Antagonist ≥92.0% Unkown
HY-125166 DB04760 Inhibitor 99.33% Unkown
HY-N1454 Apigenin-7-glucuronide 99.06% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-N2503 Ginsenoside F4 98.35% Unkown
HY-100518 T-26c 99.54% Unkown
HY-124029 BI-4394 Inhibitor 99.91% Unkown
HY-110116 SD-2590 hydrochloride Inhibitor ≥99.0% Unkown
HY-117970 MMPI-1154 Inhibitor 99.87% Unkown
HY-12168 Tanomastat Inhibitor ≥99.0% Unkown
HY-122624 MMP13-IN-2 Inhibitor 99.85% Unkown
HY-128026 MMP-9/MMP-13 Inhibitor I Inhibitor 99.90% Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-N2199 Sotetsuflavone 96.75% Unkown
HY-100518A T 26c sodium Inhibitor / Unkown
HY-107013 CP-544439 Inhibitor / Unkown
HY-107640 WAY-170523 Inhibitor / Unkown
HY-110046 CL-82198 hydrochloride Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-12168B (Rac)-Tanomastat Inhibitor / Unkown
HY-149377 MMP13-IN-4 Inhibitor / Unkown
HY-149378 MMP13-IN-5 Inhibitor / Unkown
HY-153913 MMP-9-IN-7 Inhibitor / Unkown
HY-154868 MMP-13-IN-1 Inhibitor / Unkown
HY-P2414 MMP-13 Substrate / Unkown
HY-RS08525 MMP13 Human Pre-designed siRNA Set A / Unkown
HY-RS08526 Mmp13 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08527 Mmp13 Rat Pre-designed siRNA Set A / Unkown
HY-W011085 CP-471474 Inhibitor / Unkown
HY-116302 MMP-9-IN-9 Inhibitor / Unkown
HY-43586 BR351 precursor Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp13 NCBI NCBI:4322