Trpv1 - transient receptor potential cation channel, subfamily V, member 1 Gene

Also Known as Vr1; VR-1; OTRPC1; TRPV1beta; TRPV1alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 193034

Summary

Enables Calcium Channel activity; identical protein binding activity; and temperature-gated ion channel activity. Involved in detection of temperature stimulus involved in sensory perception of pain; ion transmembrane transport; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception; diet induced thermogenesis; and fever generation. Located in neuron projection and plasma membrane. Is expressed in central nervous system; cochlea; and dorsal root ganglion. Human ortholog(s) of this gene implicated in migraine. Orthologous to human TRPV1 (transient receptor potential cation channel subfamily V member 1). [provided by Alliance of Genome Resources, Apr 2022]

Trpv1 Products (1)

mRNA Protein Name
NM_001001445.2 NP_001001445.1 transient receptor potential cation channel subfamily V member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
15489017 MGI
enables calcium channel activity IMP
IMP: Inferred from mutant phenotype
10764638 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
20351268 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18455988 MGI
enables temperature-gated ion channel activity IDA
IDA: Inferred from direct assay
18455988 MGI
enables temperature-gated ion channel activity IMP
IMP: Inferred from mutant phenotype
22634729 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral response to pain IDA
IDA: Inferred from direct assay
18455988 MGI
acts upstream of or within behavioral response to pain IMP
IMP: Inferred from mutant phenotype
17767493 MGI
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
17194758 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
17767493 MGI
acts upstream of or within catagen IMP
IMP: Inferred from mutant phenotype
16645591 MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain IDA
IDA: Inferred from direct assay
18272293 MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
18297068 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IGI
IGI: Inferred from genetic interaction
22634729 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
22634729 MGI
acts upstream of or within detection of temperature stimulus involved in thermoception IDA
IDA: Inferred from direct assay
18455988 MGI
acts upstream of or within diet induced thermogenesis IMP
IMP: Inferred from mutant phenotype
12161756 MGI
acts upstream of or within fever generation IMP
IMP: Inferred from mutant phenotype
15763167 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
12161756 MGI
involved in monoatomic ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
22634729 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23021218 MGI
acts upstream of or within peptide secretion IMP
IMP: Inferred from mutant phenotype
18172555 MGI
acts upstream of or within response to heat IMP
IMP: Inferred from mutant phenotype
10764638 MGI
acts upstream of or within response to pH IMP
IMP: Inferred from mutant phenotype
10764638 MGI
acts upstream of or within response to pain IDA
IDA: Inferred from direct assay
18272293 MGI
acts upstream of or within response to pain IMP
IMP: Inferred from mutant phenotype
18297068 MGI
acts upstream of or within sensory perception of mechanical stimulus IMP
IMP: Inferred from mutant phenotype
12161756 MGI
acts upstream of or within sensory perception of pain IMP
IMP: Inferred from mutant phenotype
10764638 MGI
acts upstream of or within sensory perception of taste IMP
IMP: Inferred from mutant phenotype
17767493 MGI
acts upstream of or within smooth muscle contraction involved in micturition IMP
IMP: Inferred from mutant phenotype
12161756 MGI
acts upstream of or within temperature homeostasis IMP
IMP: Inferred from mutant phenotype
10764638 MGI
acts upstream of or within urinary bladder smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
12161756 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
25775089 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
25775089 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
11466438 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18455988 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
25775089 MGI
is active in postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
25775089 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily V member 1

  • capsaicin receptor

  • cation channel

  • deltaN-TRPv1

  • osm-9-like TRP channel 1

  • transient receptor potential cation channel V1

  • vanilloid receptor 1

  • vanilloid receptor subtype 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16413 Protokylol hydrochloride Agonist 99.07% Unkown
HY-A0191 Dexbrompheniramine Antagonist 99.93% Unkown
HY-124073 Dihydrocapsiate Agonist 99.33% Unkown

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-118785 MSP-3 Agonist 98.53% Phase 2
HY-114017 Libvatrep Antagonist 99.54% Phase 2
HY-12914 V116517 Antagonist / Phase 2
HY-W517163 MK-2295 Antagonist / Phase 2
HY-19589 JTS-653 Antagonist / Phase 2
HY-N8377 Capsiate Agonist 99.85% Phase 1
HY-P10762 Ricorfotide vedotin Ligand 98.45% Phase 1
HY-10635 ABT-102 Antagonist 98.50% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10863 Anandamide Activator ≥99.0% Unkown
HY-12245 SB-366791 Antagonist 99.29% Unkown
HY-N0361 Dihydrocapsaicin Agonist 99.93% Unkown
HY-120691A GSK205 Antagonist 99.47% Unkown
HY-107436 LE135 Activator 99.0% Unkown
HY-108448 N-Oleoyldopamine Agonist 99.47% Unkown
HY-101323 Olvanil Agonist ≥99.0% Unkown
HY-N8264 Moringin Agonist 99.95% Unkown
HY-132596A Tivanisiran sodium Inhibitor 96.85% Unkown
HY-100129 JNJ-17203212 Antagonist 99.44% Unkown
HY-N5084 Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside Antagonist 98.92% Unkown
HY-N0637A (±)-Eriodictyol Inhibitor 99.9% Unkown
HY-136363 MDR-652 Agonist 98.08% Unkown
HY-110018 N-Arachidonyldopamine Activator 98.36% Unkown
HY-144372 TRPV1 antagonist 3 Antagonist 99.30% Unkown
HY-101389 (R)-Methanandamide Agonist 99.61% Unkown
HY-N7144A Citronellyl acetate 98.0% Unkown
HY-103333 Arvanil Agonist 99.1% Unkown
HY-120962 N-Arachidonoyl Taurine Activator 99.3% Unkown
HY-120294 Chrysin 6-C-glucoside 8-C-arabinoside Inhibitor 98.55% Unkown
HY-185011 AM9053 Activator 98.36% Unkown
HY-103325 JTE-907 Activator 98.54% Unkown
HY-172774 TRPV1 antagonist 10 Antagonist 98.54% Unkown
HY-W014394 Vanillyl butyl ether Agonist 99.75% Unkown
HY-P1175 L-R4W2 Antagonist 98.13% Unkown
HY-W790266 Polygodial pyridazine Agonist / Unkown
HY-162908 TRPV1/CB2 agonist 1 Agonist / Unkown
HY-105324 GRC-6211 Antagonist / Unkown
HY-P11022 TL-119 Inhibitor / Unkown
HY-106427 SA-13353 Agonist / Unkown
HY-115133 ABT-116 Antagonist / Unkown
HY-176063 TRPV1 antagonist 11 Antagonist / Unkown
HY-111218 TRPV1 antagonist 5 Antagonist / Unkown
HY-167160 AZ12099548 Antagonist / Unkown
HY-182517 AG1529 Antagonist / Unkown
HY-156959 Ovalicin Inhibitor / Unkown
HY-120037 A 80426 Inhibitor / Unkown
HY-157766 FAAH/TRPV1 blocker-1 Inhibitor / Unkown
HY-P1175A L-R4W2 TFA Antagonist / Unkown
HY-108459 6-Iodonordihydrocapsaicin Antagonist / Unkown
HY-165459 KJM429 Modulator / Unkown
HY-184331 FAAH-IN-10 Antagonist / Unkown
HY-183857 DD-161515 Inhibitor / Unkown
HY-184973 2,2-Diphenyltetrahydrofuran Antagonist / Unkown
HY-181463 20-Hydroxy-N-arachidonoyl taurine Activator / Unkown
HY-N11077 4,5-Di-O-caffeoylquinic acid Activator 98% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpv1 NCBI NCBI:7442