Ret - ret proto-oncogene Gene

Also Known as PTC; RET9; RET51; c-Ret

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19713

About Ret

Chromosome 6: 118,128,706-118,174,679 reverse strand.GRCm39:CM000999.3

This gene has 2 transcripts (splice variants), 205 orthologues, 53 paralogues and is associated with 115 phenotypes. Broad expression in cerebellum adult (RPKM 5.3), subcutaneous fat pad adult (RPKM 4.5) and 18 other tissues.

Summary

Enables transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including Peyer's patch morphogenesis; neuron cell-cell adhesion; and positive regulation of metanephric glomerulus development. Acts upstream of or within several processes, including animal organ development; nervous system development; and positive regulation of macromolecule metabolic process. Predicted to be located in several cellular components, including endosome; membrane raft; and neuronal cell body. Predicted to be part of plasma membrane protein complex and receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; gut; nervous system; and sensory organ. Used to study Hirschsprung's disease; clubfoot; multiple endocrine neoplasia type 2B; and pheochromocytoma. Human ortholog(s) of this gene implicated in Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (RET proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Ret Products (2)

mRNA Protein Name
NM_009050.2 NP_033076.2 proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor
NM_001080780.1 NP_001074249.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9452475 MGI
enables transmembrane receptor protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
28846099 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within MAPK cascade IGI
IGI: Inferred from genetic interaction
15569713 MGI
involved in Peyer's patch morphogenesis IMP
IMP: Inferred from mutant phenotype
17322904 MGI
acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway IGI
IGI: Inferred from genetic interaction
9576965 MGI
acts upstream of or within embryonic epithelial tube formation IGI
IGI: Inferred from genetic interaction
15569713 MGI
acts upstream of or within enteric nervous system development IMP
IMP: Inferred from mutant phenotype
9834195 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
11069590 MGI
acts upstream of or within neural crest cell migration IMP
IMP: Inferred from mutant phenotype
15242795 MGI
involved in neuron cell-cell adhesion IDA
IDA: Inferred from direct assay
21357690 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
17553423 MGI
acts upstream of or within neuron maturation IMP
IMP: Inferred from mutant phenotype
15233745 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17047028 MGI
acts upstream of or within positive regulation of cell size IMP
IMP: Inferred from mutant phenotype
17553423 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22897442 MGI
involved in positive regulation of metanephric glomerulus development IMP
IMP: Inferred from mutant phenotype
17047028 MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
23872421 MGI
acts upstream of or within regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
17553423 MGI
involved in response to pain IMP
IMP: Inferred from mutant phenotype
20237269 MGI
acts upstream of or within ureter maturation IMP
IMP: Inferred from mutant phenotype
21521737 MGI
acts upstream of or within ureteric bud development IMP
IMP: Inferred from mutant phenotype
12195422 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ret Protein Structure

RET_CLD1

RET_CLD1: pfam17756 (28 - 153)

Cadherin

Cadherin: pfam00028 (172 - 261)

RET_CLD3

RET_CLD3: pfam17812 (265 - 379)

RET_CLD4

RET_CLD4: pfam17813 (408 - 507)

PTKc_RET

PTKc_RET: cd05045 (723 - 1012)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1073 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase receptor Ret

  • proto-oncogene c-Ret

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10981 Lenvatinib Inhibitor 99.75% Yes
HY-10331 Regorafenib Inhibitor 99.97% Yes
HY-10981A Lenvatinib mesylate Inhibitor 99.91% Yes
HY-114370 Selpercatinib Inhibitor 99.83% Yes
HY-112301 Pralsetinib Inhibitor 99.98% Yes
HY-10331A Regorafenib monohydrate Inhibitor 99.94% Yes
HY-13308 Regorafenib Hydrochloride Inhibitor 99.58% Yes
HY-10331B Regorafenib mesylate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-10206 Amuvatinib Inhibitor 99.40% Phase 2
HY-132846 Vepafestinib Inhibitor 98.61% Phase 2
HY-145565 Enbezotinib Inhibitor 99.50% Phase 2
HY-149451 SYHA1815 Inhibitor / Phase 2
HY-10032 PF 477736 Inhibitor 99.04% Phase 1
HY-100459 GSK3179106 Inhibitor 99.81% Phase 1
HY-139590 Zeteletinib Inhibitor 98.31% Phase 1
HY-116116 Tafetinib Inhibitor 96.20% Phase 1
HY-178061 APS03118 Inhibitor / Phase 1
HY-149413 FHND5071 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (125)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15002 AST 487 Inhibitor 98.90% Unkown
HY-10410 TG101209 Inhibitor 98.81% Unkown
HY-101963 AD80 Inhibitor 99.88% Unkown
HY-18840 BBT594 Inhibitor 99.81% Unkown
HY-156135 NSC194598 Inhibitor 98.90% Unkown
HY-153175 BT44 Activator 98.87% Unkown
HY-162565 CDD-2807 Inhibitor 99.52% Unkown
HY-N10889 Sominone Activator 99.96% Unkown
HY-136534 RET V804M-IN-1 Inhibitor 99.36% Unkown
HY-13342AS Apatinib-d8 free base 92.5% Unkown
HY-P10044 IGF1Rtide 99.53% Unkown
HY-18507 AD57 Inhibitor 98.27% Unkown
HY-110193 SPP-86 Inhibitor 99.87% Unkown
HY-101246 RPI-1 Inhibitor 98.47% Unkown
HY-10981S Lenvatinib-d4 Inhibitor 99.59% Unkown
HY-112301A trans-Pralsetinib Inhibitor 98.06% Unkown
HY-15769 WHI-P180 Inhibitor 99.84% Unkown
HY-U00437 Pz-1 Inhibitor 99.90% Unkown
HY-133551 WF-47-JS03 Inhibitor 99.63% Unkown
HY-148742 RET-IN-21 Inhibitor 97.00% Unkown
HY-133553 RET-IN-3 Inhibitor 99.51% Unkown
HY-18317 JNJ-38158471 Inhibitor 97.02% Unkown
HY-34595 Pyrazoloadenine Inhibitor 99.98% Unkown
HY-10331S Regorafenib-d3 Inhibitor 98.0% Unkown
HY-10206A Amuvatinib hydrochloride Inhibitor / Unkown
HY-132193 RET-IN-4 Inhibitor / Unkown
HY-139590A Zeteletinib hemiadipate Inhibitor / Unkown
HY-143545 RET-IN-8 Inhibitor / Unkown
HY-170373 RET ligand-1 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-117873A KBP-7018 hydrochloride Inhibitor / Unkown
HY-147563 RET-IN-17 Inhibitor / Unkown
HY-170856 RET ligand-4 Ligand / Unkown
HY-E70771 RET L730I Recombinant Human Active Protein Kinase / Unkown
HY-E70767 RET G691S Recombinant Human Active Protein Kinase / Unkown
HY-151987 RET-IN-20 Inhibitor / Unkown
HY-E70769 RET G810R Recombinant Human Active Protein Kinase / Unkown
HY-183783 PROTAC RET Degrader 2 Degrader / Unkown
HY-144422 RET-IN-15 Inhibitor / Unkown
HY-178964 PROTAC RET Degrader 1 Degrader / Unkown
HY-170926 CQ1373 Inhibitor / Unkown
HY-180551 ZW-6-052 Degrader / Unkown
HY-170019 RET-IN-28 Inhibitor / Unkown
HY-159824 Soxataltinib Inhibitor / Unkown
HY-170809 RET-IN-29 Inhibitor / Unkown
HY-144131 RET-IN-11 Inhibitor / Unkown
HY-151945 TRK II-IN-1 Inhibitor / Unkown
HY-164413 CLM3 Inhibitor / Unkown
HY-10981S2 Lenvatinib-15N,d4 Inhibitor 98.01% Unkown
HY-176937 HSN608 Inhibitor / Unkown
HY-14979 ML786 Inhibitor / Unkown
HY-168867 RD-23 Degrader / Unkown
HY-180550 ZW-18-116 Degrader / Unkown
HY-156471 RET-IN-26 Inhibitor / Unkown
HY-E70774 RET R749T Recombinant Human Active Protein Kinase / Unkown
HY-171146 HSN748 Inhibitor / Unkown
HY-178786 RET-IN-31 Inhibitor / Unkown
HY-168105 RET-IN-27 Inhibitor / Unkown
HY-E70859 RET L790F Recombinant Human Active Protein Kinase / Unkown
HY-E70768 RET G810C Recombinant Human Active Protein Kinase / Unkown
HY-148015 Enbezotinib (enantiomer) Inhibitor 99.72% Unkown
HY-176885A CDD-2212 Inhibitor / Unkown
HY-E70770 RET G810S Recombinant Human Active Protein Kinase / Unkown
HY-184396 GR2-128 Inhibitor / Unkown
HY-170855A YW-N-7 TFA Degrader / Unkown
HY-183729 RET-IN-34 Inhibitor / Unkown
HY-143615 RET-IN-10 Inhibitor / Unkown
HY-182741 RET-IN-32 Inhibitor / Unkown
HY-E70776 RET S891A Recombinant Human Active Protein Kinase / Unkown
HY-161775 RET/TRKA-IN-1 Inhibitor / Unkown
HY-145024 RET-IN-6 Inhibitor / Unkown
HY-183931 NPA101.3 Inhibitor / Unkown
HY-176885 CDD-2211 Inhibitor / Unkown
HY-E70781 RET Y806H Recombinant Human Active Protein Kinase / Unkown
HY-181895 PROTAC HyTTD Degrader-1 Degrader / Unkown
HY-143546 RET-IN-9 Inhibitor / Unkown
HY-149099 RET-IN-22 Inhibitor / Unkown
HY-E70789 BCR-RET Recombinant Human Active Protein Kinase / Unkown
HY-172952 LRRK2-IN-17 Inhibitor / Unkown
HY-18507A AD57 hydrochloride Inhibitor / Unkown
HY-174245 RET-IN-30 Inhibitor / Unkown
HY-10331S1 Regorafenib-13C,d3 Inhibitor / Unkown
HY-153676 RET-IN-23 Inhibitor / Unkown
HY-182354 VEGFR2-IN-84 Inhibitor / Unkown
HY-181918 PLM-101-C3-NHBoc / Unkown
HY-183684 RET-IN-33 Inhibitor / Unkown
HY-170852 QZ2135 Degrader / Unkown
HY-149539 PLM-101 Inhibitor / Unkown
HY-147564 RET-IN-18 Inhibitor / Unkown
HY-112950 RET-IN-1 Inhibitor / Unkown
HY-E70772 RET L730M Recombinant Human Active Protein Kinase / Unkown
HY-120214 TAS05567 / Unkown
HY-141896 RET-IN-7 Inhibitor 98.00% Unkown
HY-10981S1 Lenvatinib-d5 Inhibitor / Unkown
HY-E70779 RET V804M Recombinant Human Active Protein Kinase / Unkown
HY-E70775 RET R813Q Recombinant Human Active Protein Kinase / Unkown
HY-149415 Multi-kinase-IN-5 Inhibitor / Unkown
HY-115541 BRD4-IN-41 / Unkown
HY-146710 RET-IN-16 Inhibitor / Unkown
HY-168868 RET ligand-2 Inhibitor / Unkown
HY-114588 Tafetinib analogue 1 Inhibitor / Unkown
HY-153941 RET-IN-24 Inhibitor / Unkown
HY-151377 RET-IN-19 Inhibitor / Unkown
HY-E70766 RET E762Q Recombinant Human Active Protein Kinase / Unkown
HY-E70777 RET V804E Recombinant Human Active Protein Kinase / Unkown
HY-156113 RET-IN-25 Inhibitor / Unkown
HY-144170 RET-IN-14 Inhibitor / Unkown
HY-144029 RET-IN-13 Inhibitor / Unkown
HY-179308 RET ligand-5 Degrader / Unkown
HY-170854 RET Ligand-Linker Conjugate-1 Ligand / Unkown
HY-176884 CDD-2110 Inhibitor / Unkown
HY-145023 RET-IN-5 Inhibitor / Unkown
HY-E70778 RET V804L Recombinant Human Active Protein Kinase / Unkown
HY-170853 RET ligand-3 Degrader / Unkown
HY-146680 FLT3/ITD-IN-4 Inhibitor / Unkown
HY-E70773 RET M918T Recombinant Human Active Protein Kinase / Unkown
HY-E70780 RET Y791F Recombinant Human Active Protein Kinase / Unkown
HY-174993 FHND5071 (1H) Inhibitor / Unkown
HY-164549 XMD15-44 Inhibitor / Unkown
HY-18817 AFG210 Inhibitor / Unkown
HY-W759629 Selpercatinib-d3 Inhibitor / Unkown
HY-117873 KBP-7018 Inhibitor / Unkown
HY-15769A WHI-P180 hydrochloride Inhibitor / Unkown
HY-164482 HG-6-63-01 Inhibitor / Unkown
HY-144030 RET-IN-12 Inhibitor / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99828 Cofetuzumab Inhibitor 99.31% Unkown
HY-P992232 Anti-GFRA4 Antibody (scFv) Inhibitor / Unkown
HY-P992009 Anti-GFRA4 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ret NCBI NCBI:5979