HMGB1 - Hmgb1 high mobility group box 1 Gene

Also Known as Hmg1; Ac2-008

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25459

Summary

Enables several functions, including DNA binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of DNA ligation; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including DNA geometric change; induction of positive chemotaxis; and positive regulation of mesenchymal cell proliferation. Located in several cellular components, including cytosol; extracellular space; and membrane raft. Used to study congestive heart failure; high grade glioma; myocardial infarction; pulmonary hypertension; and sciatic neuropathy. Biomarker of several diseases, including atherosclerosis; colon adenocarcinoma; hydrocephalus; middle cerebral artery infarction; and obstructive jaundice. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human HMGB1 (high mobility group box 1). [provided by Alliance of Genome Resources, Apr 2022]

HMGB1 Products (1)

mRNA Protein Name
NM_012963.3 NP_037095.1 high mobility group protein B1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5S rRNA binding IDA
IDA: Inferred from direct assay
18845125 RGD
enables DNA binding, bending IDA
IDA: Inferred from direct assay
17964600 RGD
enables RAGE receptor binding IMP
IMP: Inferred from mutant phenotype
15644117 RGD
enables RAGE receptor binding IPI
IPI: Inferred from physical interaction
7592757 RGD
enables bent DNA binding IDA
IDA: Inferred from direct assay
10962007 RGD
enables crossed form four-way junction DNA binding IDA
IDA: Inferred from direct assay
10962007 RGD
enables cytokine activity IDA
IDA: Inferred from direct assay
14744997 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
11024186 RGD
enables four-way junction DNA binding IDA
IDA: Inferred from direct assay
1547772 RGD
enables glycolipid binding IDA
IDA: Inferred from direct assay
11279268 RGD
enables heparin binding IDA
IDA: Inferred from direct assay
11279268 RGD
enables open form four-way junction DNA binding IDA
IDA: Inferred from direct assay
10962007 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
11748221 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14581561 RGD
enables protein heterodimerization activity EXP
EXP: Inferred from Experiment
38331917 RGD
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
11024186 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA geometric change IDA
IDA: Inferred from direct assay
10962007 RGD
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
11257120 RGD
involved in cell morphogenesis IMP
IMP: Inferred from mutant phenotype
1885601 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
16354107 RGD
involved in chemotaxis IDA
IDA: Inferred from direct assay
19139725 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
17226794 RGD
acts upstream of or within induction of positive chemotaxis IDA
IDA: Inferred from direct assay
14744997 RGD
involved in male-specific defense response to bacterium IDA
IDA: Inferred from direct assay
16997939 RGD
involved in myoblast proliferation IMP
IMP: Inferred from mutant phenotype
16407300 RGD
involved in negative regulation of DNA replication IDA
IDA: Inferred from direct assay
18191612 RGD
involved in nervous system development IMP
IMP: Inferred from mutant phenotype
1885601 RGD
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19944723 RGD
involved in neuron projection development IGI
IGI: Inferred from genetic interaction
7592757 RGD
involved in positive regulation of DNA ligation IDA
IDA: Inferred from direct assay
10866811 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16407300 RGD
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
23604926 RGD
acts upstream of or within positive regulation of cell migration IDA
IDA: Inferred from direct assay
14744997 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
18929840 RGD
involved in positive regulation of interleukin-1 production IDA
IDA: Inferred from direct assay
10952726 RGD
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
10952726 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
22514737 RGD
involved in positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
10952726 RGD
involved in positive regulation of macrophage inflammatory protein 1 alpha production IDA
IDA: Inferred from direct assay
10952726 RGD
acts upstream of or within positive regulation of mesenchymal cell proliferation IDA
IDA: Inferred from direct assay
14744997 RGD
acts upstream of or within positive regulation of mitotic cell cycle IDA
IDA: Inferred from direct assay
14744997 RGD
involved in positive regulation of myeloid cell apoptotic process IDA
IDA: Inferred from direct assay
18952078 RGD
involved in positive regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
15143181 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
11507219 RGD
involved in positive regulation of smooth muscle cell migration IDA
IDA: Inferred from direct assay
11257120 RGD
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
10952726 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
22514737 RGD
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
1547772 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
18596634 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
15192048 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19959191 RGD
involved in response to type II interferon IMP
IMP: Inferred from mutant phenotype
18004227 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16125245 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
14499952 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
20160670 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
14499952 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high mobility group protein B1

  • Ac2-008-like

  • HMG-1

  • amphoterin

  • heparin-binding protein p30

  • high mobility group 1

  • high mobility group protein 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14519 Methotrexate Inhibitor 99.95% Yes
HY-N0184 Glycyrrhizic acid Inhibitor 99.84% Yes
HY-B0581 Dexrazoxane 99.88% Yes
HY-14519A Methotrexate disodium Inhibitor 99.63% Yes
HY-N0184A Dipotassium glycyrrhizinate Inhibitor 99.68% Yes
HY-14519B Methotrexate hydrate Inhibitor 99.66% Unkown
HY-N0184R Glycyrrhizic acid (Standard) Inhibitor 97.54% Unkown
HY-14519D Methotrexate monohydrate Inhibitor / Unkown
HY-121151 (±)-Methotrexate Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9928 Alirocumab Inhibitor 97.00% Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-Y1362 Ethyl pyruvate 99.87% Phase 4
HY-P99813 Patritumab deruxtecan 99.08% Phase 3
HY-10447 Terameprocol 99.50% Phase 2
HY-113402B Gamma-glutamylcysteine ammonium / Phase 1

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101872 GSK-872 Inhibitor 99.91% Unkown
HY-113402 Gamma-glutamylcysteine 98.53% Unkown
HY-P990117 Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) Inhibitor 95.00% Unkown
HY-14307 Necrocide 1 99.55% Unkown
HY-101872A GSK-872 hydrochloride Inhibitor 98.85% Unkown
HY-111815A N4-Acetylcytidine triphosphate sodium / Unkown
HY-P2268 RAGE antagonist peptide Antagonist 98.16% Unkown
HY-162065 N6F11 Inducer 98.08% Unkown
HY-W019670 N4-Acetylcytidine 99.65% Unkown
HY-N0535 (+)-Magnoflorine chloride 99.29% Unkown
HY-148226 20-5,14-HEDGE 99.28% Unkown
HY-P3042 Chymostatin Inhibitor 99.9% Unkown
HY-113772 Inflachromene Inhibitor 99.76% Unkown
HY-N0334A (+)-Magnoflorine iodide 99.74% Unkown
HY-113402A Gamma-glutamylcysteine TFA 96.68% Unkown
HY-N0442 5-O-Methylvisammioside Inhibitor 99.90% Unkown
HY-124750 NecroX-7 Inhibitor 99.69% Unkown
HY-N1508 Ecliptasaponin A 99.81% Unkown
HY-N2055 Kaempferol 3-O-sophoroside 99.41% Unkown
HY-156675A Plecstatin-1 hydrochloride 98.96% Unkown
HY-W017180 2-(Bromomethyl)acrylic acid 97.51% Unkown
HY-14519S Methotrexate-d3 Inhibitor 99.83% Unkown
HY-P2268A RAGE antagonist peptide TFA Antagonist 99.41% Unkown
HY-172279A DSPE-PEG2000-TAT 95.0% Unkown
HY-155751 HMGB1-IN-1 Inhibitor 98.40% Unkown
HY-113402R Gamma-glutamylcysteine (Standard) 98.14% Unkown
HY-N0772 Isomangiferin 99.60% Unkown
HY-163409 CGK012 Inhibitor 99.96% Unkown
HY-N0320 Salvianolic acid D 95.15% Unkown
HY-RS06232 HMGB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N3097 Pellitorine 99.84% Unkown
HY-W753593 N4-Acetylcytidine-13C5 95.92% Unkown
HY-111815 N4-Acetylcytidine triphosphate / Unkown
HY-14519S1 Methotrexate-d3 diammonium Inhibitor 99.69% Unkown
HY-156675 Plecstatin-1 / Unkown
HY-177414 BB-1701 98.81% Unkown
HY-113402AR Gamma-glutamylcysteine TFA (Standard) 95.17% Unkown
HY-N0334 (+)-Magnoflorine / Unkown
HY-121151S (±)-Methotrexate-d3 Inhibitor / Unkown
HY-121151S2 (±)-Methotrexate-13C,d3 disodium Inhibitor / Unkown
HY-143456 Anti-inflammatory agent 18 Inhibitor / Unkown
HY-143457 Anti-inflammatory agent 19 Inhibitor / Unkown
HY-155759 HMGB1-IN-2 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-184943 Pan-PDK degrader-1 / Unkown
HY-19421 Orazamide Inhibitor / Unkown
HY-N9587 Tricin 7-O-β-D-glucopyranoside Inducer 99.23% Unkown
HY-P10321 HBP08 / Unkown
HY-P11549 pPB peptide Ligand / Unkown
HY-P5762A Phoenixin-14 TFA / Unkown
HY-110051 DPP4-In hydrochloride / Unkown
HY-167182 PUMAi Inhibitor / Unkown
HY-168053 HMGB1-IN-3 Inhibitor / Unkown
HY-182824 Sucrose dilaurate Inducer / Unkown
HY-N0442R 5-O-Methylvisammioside (Standard) Inhibitor / Unkown
HY-N20719 Vulgarin Inhibitor / Unkown
HY-RS16500 Hmgb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22930 Hmgb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25102 Hbp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P9928A Alirocumab (anti-PCSK9) Inhibitor 98.24% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens HMGB1 NCBI NCBI:3146