Scly - selenocysteine lyase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363285

Summary

Enables several functions, including protein homodimerization activity; selenocysteine lyase activity; and vitamin B6 binding activity. Involved in selenocysteine catabolic process. Part of catalytic complex. Orthologous to human SCLY (selenocysteine lyase). [provided by Alliance of Genome Resources, Apr 2022]

Scly Products (1)

mRNA Protein Name
NM_001007755.1 NP_001007756.1 selenocysteine lyase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amino acid binding IDA
IDA: Inferred from direct assay
20164179 RGD
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
20164179 RGD
enables selenocysteine lyase activity IMP
IMP: Inferred from mutant phenotype
20164179 RGD
enables vitamin B6 binding IDA
IDA: Inferred from direct assay
20164179 RGD
Biological Process GO Annotation Evidence References Source
involved in selenocysteine catabolic process IMP
IMP: Inferred from mutant phenotype
20164179 RGD
Cellular Component GO Annotation Evidence References Source
part of catalytic complex IDA
IDA: Inferred from direct assay
20164179 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

selenocysteine lyase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0361 Aspartame 99.70% Unkown
HY-17474 Parecoxib Inhibitor 99.29% Yes
HY-132587 Fitusiran 98.70% Unkown
HY-17474A Parecoxib Sodium Inhibitor 99.82% Yes
HY-B0561R Spironolactone (Standard) 98.55% Unkown
HY-17509 Deracoxib 99.96% Unkown
HY-132587A Fitusiran sodium 95.08% Unkown
HY-B0455A Lomefloxacin 99.99% Unkown
HY-B0318A Metronidazole hydrochloride 98.44% Yes
HY-B1341 Norethynodrel Activator 90.53% Unkown
HY-132587C Fitusiran sodium scrambled negative control Activator / Unkown
HY-132587D FAM labled Fitusiran sodium / Unkown
HY-132587E Cy3 labled Fitusiran sodium / Unkown
HY-B0455AR Lomefloxacin (Standard) Inhibitor / Unkown
HY-B0455B Lomefloxacin (aspartate) Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99590 Sotatercept 99.94% Unkown

Clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Phase
HY-14718 Resminostat Inhibitor 99.44% Phase 4
HY-14398GL Celecoxib (GMP Like) Inhibitor / Phase 4
HY-170554 ABBV-706 Inhibitor 99.71% Phase 3
HY-132257 Rovalpituzumab tesirine Inhibitor 97.47% Phase 3
HY-U00232 Bidisomide Ligand 99.62% Phase 3
HY-136657 SC-43 99.01% Phase 2
HY-16012 Domatinostat tosylate 99.66% Phase 2
HY-106395 Telinavir Inhibitor 98.16% Phase 2
HY-100934 SC-9 Activator 99.33% Phase 2
HY-14908A Vidofludimus hemicalcium / Phase 2
HY-19046 AGN-2979 hydrochloride Inhibitor / Phase 2
HY-19080 SC-45662 Inhibitor / Phase 2
HY-19500 SC-75416 Inhibitor / Phase 2
HY-16451 SC-49483 / Phase 2
HY-19897 4SC-203 Inhibitor 98.98% Phase 1
HY-112739 SC-41930 Agonist / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99886 Pexelizumab Inhibitor 99.0% Phase 3

Pre-clinical Phase

Bioactive Molecules (171)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18749 SC79 Activator 98.0% Unkown
HY-107410 SC-26196 Inhibitor 99.66% Unkown
HY-10496 SC75741 Inhibitor 99.24% Unkown
HY-148559 4A3-SC8 99.93% Unkown
HY-15614 SC144 99.48% Unkown
HY-145799 5A2-SC8 Chemical 99.89% Unkown
HY-59105 SC-560 Inhibitor 99.87% Unkown
HY-13802 SC-514 Inhibitor 99.97% Unkown
HY-145758 FEN1-IN-SC13 Inhibitor 98.42% Unkown
HY-126681 SC-VC-PAB-MMAE 99.07% Unkown
HY-140698 m-PEG5000-NHS ester 95.0% Unkown
HY-W591424 m-PEG2000-NHS ester Ligand 95.89% Unkown
HY-15614A SC144 hydrochloride 98.98% Unkown
HY-161409 SC912 99.13% Unkown
HY-124876 SynuClean-D Inhibitor 99.89% Unkown
HY-103226 SC-57461A Inhibitor 99.93% Unkown
HY-16012A Domatinostat 99.34% Unkown
HY-P0323A GP(33-41) TFA Inhibitor 99.62% Unkown
HY-18086 TCS PIM-1 1 Inhibitor 98.40% Unkown
HY-108562 SC-51322 Antagonist 98.93% Unkown
HY-Y0079S D-Phenylalanine-d5 99.92% Unkown
HY-W010983 SC-236 99.59% Unkown
HY-19832 SC66 99.65% Unkown
HY-157745 m-PEG40000-NHS ester 98.0% Unkown
HY-144880 SC209 Inhibitor 98.99% Unkown
HY-101955A (2R,6R)-Hydroxynorketamine hydrochloride 99.91% Unkown
HY-164373 SC428 98.0% Unkown
HY-158031 PLK1/BRD4-IN-5 98.80% Unkown
HY-100931 SC-10 Activator 99.59% Unkown
HY-108563A SC 51089 free base Antagonist 98.60% Unkown
HY-131236 EBNA1-IN-SC7 98.37% Unkown
HY-145799A 5A2-SC8 TFA Chemical 98.85% Unkown
HY-155656 Anti-inflammatory agent 49 Inhibitor 99.44% Unkown
HY-203862 Polyquaternium-51 / Unkown
HY-P10827 PIC1 PA Inhibitor 98.37% Unkown
HY-140699 m-PEG10000-NHS ester 98.0% Unkown
HY-W013164 SC-58125 Inhibitor 99.92% Unkown
HY-Y0079S1 D-Phenylalanine-d8 98.28% Unkown
HY-114857 Clofencet 98.62% Unkown
HY-120113 SC-2001 99.37% Unkown
HY-124858 SC99 98.90% Unkown
HY-177069 4A3-SC7 98.55% Unkown
HY-118827 Vedaprofen Inhibitor 98.73% Unkown
HY-138865 BiCAPPA Inhibitor 98.35% Unkown
HY-140700 m-PEG20000-NHS ester 98.0% Unkown
HY-N9319 Fulvotomentoside A 99.76% Unkown
HY-102065 SC-19220 99.86% Unkown
HY-171099 SC-919 Inhibitor 98.68% Unkown
HY-132306 CCF0058981 Inhibitor 98.02% Unkown
HY-148194 SC239 99.97% Unkown
HY-124775 (S)-C33 Inhibitor 99.46% Unkown
HY-126693 SC-VC-PAB-DM1 97.04% Unkown
HY-129982 SC-435 99.14% Unkown
HY-B0561S Spironolactone-d7 99.96% Unkown
HY-47968 SC209 intermediate-1 ≥96.0% Unkown
HY-106395A (Rac)-Telinavir Inhibitor / Unkown
HY-108563 SC 51089 Antagonist 98.64% Unkown
HY-148402 p53 Activator 3 Activator 98.35% Unkown
HY-148404 p53 Activator 5 Activator 98.43% Unkown
HY-148528 SC-VC-PAB-N-Me-L-Ala-Maytansinol 98.66% Unkown
HY-B0455S Lomefloxacin-d5 hydrochloride 99.88% Unkown
HY-B0561S1 Spironolactone-d3 99.87% Unkown
HY-P3326A Targeting the bacterial sliding clamp peptide 46 TFA Inhibitor 99.83% Unkown
HY-W009934 2-Phenyl-2-(2-pyridyl)acetonitrile 99.97% Unkown
HY-W028047 JFD01307SC Inhibitor 98.0% Unkown
HY-U00129 SC57666 Inhibitor 98.94% Unkown
HY-100857 PrPSc-IN-1 / Unkown
HY-B0361S1 Aspartame-d5 / Unkown
HY-105052 SC 34301 / Unkown
HY-105894 SC-42867 Antagonist / Unkown
HY-10828 SC-57461 Inhibitor / Unkown
HY-111251 4SC-207 / Unkown
HY-112740 SC-53228 Antagonist / Unkown
HY-113727 SC-39070 Antagonist / Unkown
HY-114786 SC-44463 Inhibitor / Unkown
HY-115360 IND45193 Inhibitor / Unkown
HY-117896 SC-50605 Antagonist / Unkown
HY-118795 SC-22716 Inhibitor / Unkown
HY-119753 Disobutamide Inhibitor / Unkown
HY-120053 SC-53606 Antagonist / Unkown
HY-120776 SC-51316 Antagonist / Unkown
HY-120794 SC-67655 / Unkown
HY-121598 Actisomide Inducer / Unkown
HY-122134 SC-58272 Inhibitor / Unkown
HY-123014 (Rac)-SC-45694 Agonist / Unkown
HY-123014A SC-45694 lithium / Unkown
HY-123229 Ropizine / Unkown
HY-123864 SC-68448 Antagonist / Unkown
HY-124985 VU6010608 Modulator / Unkown
HY-125494 Droxinavir hydrochloride Inhibitor / Unkown
HY-125494A Droxinavir Inhibitor / Unkown
HY-126667 SC-Val-Cit-PAB / Unkown
HY-129782 SC-55858 / Unkown
HY-139678 SC13 / Unkown
HY-14237 SC-77964 Inhibitor / Unkown
HY-156271 Tubulin polymerization-IN-52 Inhibitor / Unkown
HY-162791 (1s,4s)-C1-Piperidine-C1-cyclohexane-C1 / Unkown
HY-168730 Anticancer agent 259 Modulator / Unkown
HY-172133 HDAC3-IN-6 / Unkown
HY-172887 Kv7.2/Kv7.3 activator-2 Activator / Unkown
HY-172944 GPR40 Activator 3 Activator / Unkown
HY-17474AS Parecoxib-d5 sodium Inhibitor / Unkown
HY-17474S Parecoxib-d3 Inhibitor / Unkown
HY-174808 SC691 Inhibitor / Unkown
HY-17509S Deracoxib-d3 / Unkown
HY-175318S p53 Activator 15 Activator / Unkown
HY-176065 Nav1.2-IN-1 Inhibitor / Unkown
HY-178732 AB-22 Inhibitor / Unkown
HY-180145 Furin-IN-3 Inhibitor / Unkown
HY-181980 SPB07393SC Inhibitor / Unkown
HY-182309 SC83288 Inhibitor / Unkown
HY-184428 PROTAC TSSK1 Degrader-1 Degrader / Unkown
HY-184728 Antifungal agent-169 Inhibitor / Unkown
HY-400056 SC209 intermediate-2 99.60% Unkown
HY-B0561S2 Spironolactone-d3-1 / Unkown
HY-D2996 BOD-NH-SC / Unkown
HY-E70596 endo-α-1,5-Arabinanases, Paenibacillus polymyxa SC2 / Unkown
HY-N12229 Penipurdin A Inhibitor / Unkown
HY-N15703 Norisocorydine / Unkown
HY-N16606 2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone Inhibitor / Unkown
HY-N17737 Floramanoside F / Unkown
HY-N19135 SB87-H Inhibitor / Unkown
HY-N19661 1-O-Caffeoyl-3-O-galloyl-β-D-glucopyranose / Unkown
HY-N9229 Myricadenin A Inhibitor / Unkown
HY-P3326 Targeting the bacterial sliding clamp peptide 46 Inhibitor / Unkown
HY-RS12473 SC5D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12514 SCLY Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1130429 4A3-SC10 Inhibitor / Unkown
HY-W717425 SC-60 / Unkown
HY-W777079 Valdecoxib-13C2,15N / Unkown
HY-102065R SC-19220 (Standard) / Unkown
HY-106593 Prorenone Antagonist / Unkown
HY-112333 SC-68376 Inhibitor / Unkown
HY-117717 (Rac)-SC-31391 Activator / Unkown
HY-118827S Vedaprofen-d3 Inhibitor / Unkown
HY-120045A DuP 747 hydrochloride / Unkown
HY-120550 RS 49676 Inhibitor / Unkown
HY-120586 SC-46944 Inhibitor / Unkown
HY-122288 SC 28538 Inhibitor / Unkown
HY-123156 SC-23110 Inhibitor / Unkown
HY-123354 SC 44914 Inhibitor / Unkown
HY-123747 SC-53116 Agonist / Unkown
HY-123747A SC-53116 hydrochloride Agonist / Unkown
HY-137089 Azacosterol dihydrochloride Inhibitor / Unkown
HY-137225 HTS07944 / Unkown
HY-157405 DENV-IN-11 Inhibitor / Unkown
HY-163631 Antibacterial agent 218 Inhibitor / Unkown
HY-164525 SD-7300 Inhibitor / Unkown
HY-165401 SC 19886 Inhibitor / Unkown
HY-168776 (S)-C12-200 / Unkown
HY-170520 Antibiofilm agent-14 Inhibitor / Unkown
HY-172411 GLP-1R agonist 29 Agonist / Unkown
HY-172536 m-PEG30000-NHS ester / Unkown
HY-17474S1 Parecoxib-d5 Inhibitor / Unkown
HY-175697 Glycosyltransferase-IN-2 Inhibitor / Unkown
HY-181494 FAPI-X5 Inhibitor / Unkown
HY-184865 Anticancer agent 340 / Unkown
HY-B0361S Aspartame-d3 / Unkown
HY-N12164 Linearmycin B Inhibitor / Unkown
HY-N12871 Floramanoside D Inhibitor / Unkown
HY-N14006 Louisianin D / Unkown
HY-N14139 Dioxamycin Inhibitor / Unkown
HY-N14632 Louisianin A / Unkown
HY-N14633 Louisianin B / Unkown
HY-N14634 Louisianin C / Unkown
HY-RS19952 Scly Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26454 Scly Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W703540 Deracoxib-d4 / Unkown
HY-P0323 GP(33-41) Inhibitor / Unkown
HY-U00200 Dicirenone Antagonist / Unkown
HY-U00239 SC58451 Inhibitor / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991041 Turmetabart 99.75% Unkown
HY-P99506 Tamrintamab 98.51% Unkown
HY-P990664 Anti-Melanotransferrin/CD228 Antibody 99.34% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scly NCBI NCBI:51540