Cat. No.: HY-N0638

Dendrobine

7 Cited Publications

Customer Review

Based on 7 publication(s) in Google Scholar

Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC₅₀s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2 signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties.

For research use only. We do not sell to patients.

Purity: 99.92%
CAS No.: 2115-91-5
Formula: C₁₆H₂₅NO₂
Molecular Weight:263.38

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Dendrobine Chemical Structure

CAS No.: 2115-91-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 3.39 μM (A/FM-1/1/47), 2.16 μM (A/Puerto Rico/8/34 H274Y), 5.32 μM (A/Aichi/2/68)^[1]

All JNK Isoforms :

All p38 MAPK Isoforms :

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>40 μM Compound: 5	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29338260]
HL-60	IC₅₀	>40 μM Compound: 5	Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29338260]
MCF7	IC₅₀	>40 μM Compound: 5	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29338260]
SMMC-7721	IC₅₀	>40 μM Compound: 5	Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29338260]
SW480	IC₅₀	>40 μM Compound: 5	Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29338260]

In Vitro

Dendrobine (1-10 μg/mL, 24 h) inhibits the cell viability, migration and invasion of cancer cell A549^[2].
Dendrobine (0.001-0.1 µM, 36 h) inhibits Aβ1−42-induced apoptosis in cell PC12 by inhibiting the activation of CDK5, and regulating the apoptosis-related proteins^[3].
Dendrobine (0.01-1 µM, 36 h) inhibits the ROS and MDA generation, activates the antioxidant enzymes SOD, CAT and GSH-Px, thereby exhibiting antioxidant efficacy in HACAT cell^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

A549
Concentration:

1-10 μg/mL
Incubation Time:

24 h
Result:

Inhibited cell viability.

Real Time qPCR^[3]

Cell Line:

PC12
Concentration:

0.001-0.1 µM
Incubation Time:

12 h
Result:

Upregulated the expression of Bcl-2, downregulated the expression of Bax, cytochrome c and caspase-3.

In Vivo

Dendrobine (25 mg/kg, ip for 14 days) exhibits antitumor efficacy in A549 xenograft mouse models^[2].
Dendrobine (20 mg/kg, po for 20 days) ameliorates gestational diabetes mellitus (GDM) in mouse models^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

A549 xenograft BALB/c mouse models^[2]
Dosage:

25 mg/kg
Administration:

ip for 14 days
Result:

Inhibited tumor growth.

Animal Model:

GDM mouse models^[5]
Dosage:

20 mg/kg
Administration:

po for 20 days
Result:

Improved glucose and insulin tolerance, reduced Th17 cells in the spleen of GDM mice.

Chemical Information

CAS No. 2115-91-5
Appearance Solid
Molecular Weight 263.38
Formula C₁₆H₂₅NO₂
Color White to yellow
SMILES

O=C1O[C@]2([H])[C@@H](C(C)C)[C@@]1([H])[C@@](CC3)([H])[C@]4(C)[C@@]3([H])CN(C)[C@]24[H]
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (7)

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Journal Impact Factor

Phytomedicine

Dendrobine attenuates lipopolysaccharide-induced acute lung injury by modulating FAM134B-mediated endoplasmic reticulum autophagy and mitochondrial function. [Abstract]

2025 Aug:144:156952. PMID: 40532488
J Ethnopharmacol

Dendrobine alleviates LPS-induced acute lung injury via activation of the PI3K/AKT/GSK3β pathway. [Abstract]

2025 Apr 25:346:119634. PMID: 40089200
J Agric Food Chem

Dendrobine Ameliorates Glucocorticoid-Induced Osteoporosis by Promoting Osteogenesis through JNK/p38 MAPK Pathway Activation and GR Nuclear Translocation Inhibition. [Abstract]

2024 Jul 31;72(30):16739-16748. PMID: 39033544
Int Immunopharmacol

Dendrobine attenuates sepsis-associated acute kidney injury by promoting PINK1/PARKIN-mediated mitophagy. [Abstract]

2025 Jun 5:157:114741. PMID: 40306112
Drug Dev Res

Dendrobine modulates autophagy to alleviate ox-LDL-induced oxidative stress and senescence in HUVECs. [Abstract]

2022 Aug;83(5):1125-1137. PMID: 35417048
J Pharmacol Sci

Dendrobine alleviates lung injury in septic mice by inhibiting mitochondrial-endoplasmic reticulum crosstalk-mediated NLRP3 inflammasome activation. [Abstract]

2026 Aug;161(4):119-129. PMID: 42303347
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (126.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.7968 mL

18.9839 mL

37.9678 mL

5 mM

0.7594 mL

3.7968 mL

7.5936 mL

10 mM

0.3797 mL

1.8984 mL

3.7968 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (9.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (9.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (9.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (288 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li R, et al. Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action. J Agric Food Chem. 2017 May 10;65(18):3665-3674. [Content Brief]

[2]. Kim YR, et al., Dendrobine Inhibits γ-Irradiation-Induced Cancer Cell Migration, Invasion and Metastasis in Non-Small Cell Lung Cancer Cells. Biomedicines. 2021 Aug 3;9(8):954. [Content Brief]

[3]. Zhang CC, et al., Two new alkaloids from Dendrobium nobile Lindl. exhibited neuroprotective activity, and dendrobine alleviated Aβ1-42 -induced apoptosis by inhibiting CDK5 activation in PC12 cells. Drug Dev Res. 2023 Apr;84(2):262-274. [Content Brief]

[4]. Yue Q, et al., Dendrobine protects HACAT cells from H2O2-induced oxidative stress and apoptosis damage via Nrf2/Keap1/ARE signaling pathway. Toxicol Appl Pharmacol. 2022 Nov 1;454:116217. [Content Brief]

[5]. Feng Y, et al., Dendrobine attenuates gestational diabetes mellitus in mice by inhibiting Th17 cells. Basic Clin Pharmacol Toxicol. 2021 Mar;128(3):379-385. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.7968 mL	18.9839 mL	37.9678 mL	94.9195 mL
	5 mM	0.7594 mL	3.7968 mL	7.5936 mL	18.9839 mL
	10 mM	0.3797 mL	1.8984 mL	3.7968 mL	9.4920 mL
	15 mM	0.2531 mL	1.2656 mL	2.5312 mL	6.3280 mL
	20 mM	0.1898 mL	0.9492 mL	1.8984 mL	4.7460 mL
	25 mM	0.1519 mL	0.7594 mL	1.5187 mL	3.7968 mL
	30 mM	0.1266 mL	0.6328 mL	1.2656 mL	3.1640 mL
	40 mM	0.0949 mL	0.4746 mL	0.9492 mL	2.3730 mL
	50 mM	0.0759 mL	0.3797 mL	0.7594 mL	1.8984 mL
	60 mM	0.0633 mL	0.3164 mL	0.6328 mL	1.5820 mL
	80 mM	0.0475 mL	0.2373 mL	0.4746 mL	1.1865 mL
	100 mM	0.0380 mL	0.1898 mL	0.3797 mL	0.9492 mL

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Dendrobine

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Publications Citing Use of MedChemExpress (MCE) Dendrobine

All JNK Isoforms

All p38 MAPK Isoforms

All CDK Isoforms

Biological Activity

Chemical Information

Publications (7)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Dendrobine Related Classifications