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製品番号: HY-107101

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(5R)-5-Hydroxytriptolide

(別名: PG 701; LLDT-8; 5α-Hydroxytriptolide)

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(5R)-5-Hydroxytriptolide is an extracted compound from Tripterygium, and shows lower cell cytotoxicity and higher immunosuppressive activity. (5R)-5-Hydroxytriptolide can be used for study of rheumatoid arthritis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.67%
CAS 番号: 583028-68-6
分子式: C₂₀H₂₄O₇
分子量:376.40

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(5R)-5-Hydroxytriptolide 構造式

CAS 番号: 583028-68-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.04 nM Compound: 7; LLDT-8	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 31121546]
BGC-823	IC₅₀	1.5 μM Compound: 7; LLDT-8	Cytotoxicity against human BGC823 cells assessed as decrease in cell viability by MTT assay Cytotoxicity against human BGC823 cells assessed as decrease in cell viability by MTT assay	[PMID: 31121546]
HeLa	IC₅₀	0.34 μM Compound: 7; LLDT-8	Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay	[PMID: 31121546]
HL-60	IC₅₀	0.04 nM Compound: 7; LLDT-8	Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 31121546]
HL-60	IC₅₀	0.47 μM Compound: 7; LLDT-8	Cytotoxicity against human HL60 cells assessed as decrease in cell viability by MTT assay Cytotoxicity against human HL60 cells assessed as decrease in cell viability by MTT assay	[PMID: 31121546]
KB	IC₅₀	0.3 μM Compound: 7; LLDT-8	Cytotoxicity against human KB cells assessed as decrease in cell viability by MTT assay Cytotoxicity against human KB cells assessed as decrease in cell viability by MTT assay	[PMID: 31121546]
MCF7	IC₅₀	0.04 nM Compound: 7; LLDT-8	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 31121546]
MCF7	IC₅₀	1.05 μM Compound: 7; LLDT-8	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by MTT assay	[PMID: 31121546]
MKN-28	IC₅₀	0.04 nM Compound: 7; LLDT-8	Cytotoxicity against human MKN28 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human MKN28 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 31121546]
P388	IC₅₀	0.04 nM Compound: 7; LLDT-8	Cytotoxicity against mouse P388 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against mouse P388 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 31121546]
PC-3	IC₅₀	0.275 μM Compound: 4	Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation by sulforhodamine B assay Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation by sulforhodamine B assay	[PMID: 25467158]
U-251	IC₅₀	0.488 μM Compound: 4	Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay	[PMID: 25467158]

化学情報

CAS 番号 583028-68-6
性状 Solid
分子量 376.40
分子式 C₂₀H₂₄O₇
Color White to off-white
SMILES

CC([C@@]12[C@H]([C@H]3[C@]4([C@@]5(C)CCC6=C(COC6=O)[C@]5(O)C[C@H]7[C@@]4(O7)[C@@H]2O)O3)O1)C
別名

PG 701; LLDT-8; 5α-Hydroxytriptolide
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Guo S, et al. (5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients. Sci Rep. 2019;9(1):11155. Published 2019 Aug 1. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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化学情報
純度とドキュメンテーション
参考文献

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(5R)-5-Hydroxytriptolide

Interleukin Related アイソフォーム固有の製品をすべて表示

HIV アイソフォーム固有の製品をすべて表示

JNK アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示

TNF Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

(5R)-5-Hydroxytriptolide 関連分類

HY-107101 関連分類