Antcin K
Antcin K is a selective inhibitor targeting the PI3K/Akt, NF-κB, MEK1/2-ERK, p38 and AP-1 pathways. Antcin K upregulates IL-10 expression, thereby inhibiting the production of pro-inflammatory factors, blocking monocyte adhesion, reducing tissue damage, and promoting myogenesis. Antcin K has significant anti-inflammatory, anti-damage and tissue protective activities. Antcin K is mainly used in the research of inflammation-related diseases such as periodontitis, rheumatoid arthritis, and skeletal muscle injury.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 741268-13-3
- 分子式: C29H44O6
- 分子量:488.66
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
AP-1 アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | ED50 |
>20 μg/mL
Compound: 32
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Cytotoxicity against human HeLa cells after 3 days by MTT assay
Cytotoxicity against human HeLa cells after 3 days by MTT assay
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[PMID: 21115251] |
| HEp-2 | ED50 |
>20 μg/mL
Compound: 32
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Cytotoxicity against human Hep2 cells after 3 days by MTT assay
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
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[PMID: 21115251] |
| MCF7 | ED50 |
>20 μg/mL
Compound: 32
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Cytotoxicity against human MCF7 cells after 3 days by MTT assay
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
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[PMID: 21115251] |
化学情報
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CAS 番号 741268-13-3
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分子量 488.66
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分子式 C29H44O6
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SMILES
C[C@@]12C3=C([C@H](C[C@@]1([H])[C@@](O)([C@@H](CC2)O)C)O)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC(C(C)C(O)=O)=C)C
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Structure Classification
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Initial Source
Antrodia cinnamomea
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Wu YH, et al. Antcin K suppresses proinflammatory cytokines expression via the PI3K, Akt and NF-κB pathways in human gingival fibroblasts: implications for periodontitis treatment. Cell Death Discov. 2025 Nov 22. [Content Brief]
[2]. Achudhan D, et al. Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts. Food Nutr Res. 2022 Jun 2;66. [Content Brief]
[3]. Chang TK, et al. Antcin K ameliorates cardiotoxin-induced skeletal muscle injury and inflammation via IL-10 regulation. Int J Biol Sci. 2025 Mar 19;21(6):2493-2507. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antcin K 関連分類
HY-N9980 関連分類
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