Avicin D
Avicin D is a plant triterpenoid. Avicin D induces Autophagy by activation of AMPK. Avicin D inhibits mTOR and S6 kinase activity. Avicin D selectively induces Apoptosis and downregulates p-STAT-3, bcl-2, and Survivin. Avicin D has properties of being a selective Glucocorticoid receptor modulator. Avicin D inhibits NF-κB activation. Avicin D shows anti-tumor effects against cutaneous T-cell lymphomas.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 197787-20-5
- 分子式: C98H155NO46
- 分子量:2083.26
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
AMPK アイソフォーム固有の製品をすべて表示
More
生物活性
|
Bcl-2 |
p-STAT3 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
0.58 μg/mL
Compound: 1, avicin D
|
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
|
[PMID: 12828461] |
化学情報
-
CAS 番号 197787-20-5
-
分子量 2083.26
-
分子式 C98H155NO46
-
SMILES
O=C([C@]([C@@H](C[C@]12C)O)(C[C@@H]3OC(/C(CO)=C/CC[C@@](C=C)(C)O[C@H](O[C@@H]4C)[C@@H]([C@H]([C@@H]4OC(/C(CO)=C/CC[C@@](C)(O)C=C)=O)O)O)=O)[C@](CC(C)3C)([H])C1=CC[C@@]5([H])[C@]2(CC[C@](C(C)6C)([H])[C@@]5(CC[C@@H]6O[C@H](O[C@@H]7CO[C@H](O[C@@H]8C)[C@@H]([C@H]([C@H]8O)O)O[C@H](OC[C@H]9O)[C@@H]([C@H]9O)O)[C@@H]([C@H]([C@@H]7O)O)NC(C)=O)C)C)O[C@H](O[C@@H]%10CO)[C@@H]([C@H]([C@@H]%10O)O)O[C@H](O[C@H]%11C)[C@@H]([C@@H]([C@H]%11O[C@@H]([C@@H]([C@H]%12O)O)O[C@H]%12CO)O[C@@H]([C@@H]([C@H]%13O)O)O[C@@H]([C@H]%13O)CO)O
-
Structure Classification
-
Initial Source
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Xu ZX, et al. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell Death Differ. 2007 Nov;14(11):1948-57. [Content Brief]
[2]. Zhang C, et al. Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells. J Invest Dermatol. 2008 Nov;128(11):2728-2735. [Content Brief]
[3]. Haridas V, et al. The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism. PLoS One. 2011;6(11):e28037. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Avicin D 関連分類
HY-N13338 関連分類
Powered by Bioz