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製品番号: HY-137135

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Cantharidic acid

Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway.

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CAS 番号: 28874-45-5
分子式: C₁₀H₁₄O₅
分子量:214.22

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Cantharidic acid 構造式

CAS 番号: 28874-45-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

ERK アイソフォーム固有の製品をすべて表示 :

p38 MAPK アイソフォーム固有の製品をすべて表示 :

JNK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	218.5 μM Compound: 4	Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33454654]
HL-60	IC₅₀	103.2 μM Compound: 4	Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33454654]
KB 3-1	IC₅₀	79.2 μM Compound: 4	Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33454654]
leukaemia cell line	IC₅₀	>50 μM Compound: 4	Anticancer activity against human leukaemia cell line assessed as cell growth inhibition Anticancer activity against human leukaemia cell line assessed as cell growth inhibition	[PMID: 33454654]

化学情報

CAS 番号 28874-45-5
分子量 214.22
分子式 C₁₀H₁₄O₅
SMILES

OC([C@@]([C@@]1(C)C(O)=O)([C@@H]2O[C@H]1CC2)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chen YC, et al., Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35(5):619-627. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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生物活性
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化学情報
純度とドキュメンテーション
参考文献

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Cantharidic acid

ERK アイソフォーム固有の製品をすべて表示

p38 MAPK アイソフォーム固有の製品をすべて表示

JNK アイソフォーム固有の製品をすべて表示