Catenarin
Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice[1][2].
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- CAS 番号: 476-46-0
- 分子式: C15H10O6
- 分子量:286.24
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Calu-1 | IC50 |
>100 μM
Compound: 11
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Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
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[PMID: 11374975] |
| HeLa | IC50 |
>100 μM
Compound: 11
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Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
|
[PMID: 11374975] |
| K562 | IC50 |
>100 μM
Compound: 11
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Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
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[PMID: 11374975] |
| Raji | IC50 |
>100 μM
Compound: 11
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Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
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[PMID: 11374975] |
| RAW264.7 | IC50 |
41.32 μM
Compound: 6, Catenarin
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 15 mins prior to LPS challenge measured after 20 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 15 mins prior to LPS challenge measured after 20 hrs by Griess assay
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[PMID: 24016057] |
| Vero | IC50 |
>100 μM
Compound: 11
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Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
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[PMID: 11374975] |
| WISH | IC50 |
>100 μM
Compound: 11
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Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
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[PMID: 11374975] |
Catenarin (0-2.5 μg/mL, 1 h) inhibits CCR5 (IC50 = 0.24 μg/mL) mediated chemotaxis in JK-EF1α-CCR5 cells and CXCR4 (IC50 = 0.46 μg/mL) mediated chemotaxis in Jurkat cells[1].
Catenarin (1-5 μg/mL, 1 h) inhibits calcium mobilization in CCR5 and CXCR4 pathways in JK-EF1α-CCR5 cells and Jurkat cells[1].
Catenarin (1 μg/mL, 0-15 min) inhibits the activation of MAPK cascades in CCR5 and CXCR4 pathways in JK-EF1α-CCR5 cells and Jurkat cells[1].
Catenarin (1 μg/mL, 1 h) does not affect surface expression of CCR5 and CXCR4 receptors in JK-EF1α-CCR5 cells or Jurkat cells[1].
Catenarin (0.1-0.2 μg/mL, 0-10 h) exhibits significant inhibitory effects against Gram-positive bacteria with a minimum inhibitory concentration (MIC) of 1 μg/mL in complex media and 0.2 μg/mL in synthetic media[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells and JK-EF1α-CCR5 cells
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Concentration:0.5 μg/mL
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Incubation Time:8 h
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Result:Abolished the movement of Jurkat cells and JK-EF1α-CCR5 cells toward SDF-1β and MIP-1β.
Abolished Jurkat cell migration mediated by MKK6 and MKK7.
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Cell Line:Jurkat cells, JK-EF1α-CCR5 cells and JK-EF1α-CCR5 cells
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Concentration:1 μg/mL
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Incubation Time:0, 5, 10, 15 min
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Result:Inhibited the phosphorylation of the p38 and JNK in JK-EF1α-CCR5 and Jurkat cells in response to MIP-1β and SDF-1β.
Increased the phosphorylation of ERK1/2.
Reduced the phosphorylation of MKK6 in K-EF1α-CCR5 cells triggered by MIP-1β and Jurkat cells triggered by SDF-1β.
Decreased the phosphorylation of MKK7.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female NOD mice (4-30 weeks)[1]
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Dosage:0.4, 4, and 20 mg/kg
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Administration:i.p. three times per week for 26 weeks
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Result:Reduced diabetes in the age-matched mice by 33%, 86%, and 100%.
Prevented T1D in NOD mice to a greater extent than Aspirin (acetylsalicylic acid) (HY-14654).
Showed a marginal-to-modest islet destruction and leukocyte infiltration at 4 mg/kg and over.
Reduced the level of blood glucose and HbA1C at 4 mg/kg and over.
Reduced the number of CD8+ T cells and dendritic cells.
化学情報
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CAS 番号 476-46-0
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分子量 286.24
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分子式 C15H10O6
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SMILES
O=C1C2=C(C(C3=C(C=C(C)C(O)=C13)O)=O)C(O)=CC(O)=C2
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別名
Katenarin
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Structure Classification
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Initial Source
Conoideocrella krungchingensis
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Shen MY, et al. Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways. Evid Based Complement Alternat Med. 2012;2012:982396. [Content Brief]
[2]. Anke H, et al. The anthraquinones of the Aspergillus glaucus group. I. Occurrence, isolation, identification and antimicrobial activity. Arch Microbiol. 1980 Jul;126(3):223-30. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Catenarin 関連分類
HY-N11723 関連分類
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