PCC0105005
PCC0105005 is a dual-target CGRP Receptor antagonist (IC50 = 1.01 nM) and a partial agonist of 5-HT1F Receptor (EC50 = 77.91 nM). PCC0105005 shows significant efficacy in the rat model of migraine. PCC0105005 significantly reduces the expression of CGRP and c-Fos proteins, and inhibits the phosphorylation levels of ERK and CREB. PCC0105005 can be used for research on migraine.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2921670-99-5
- 分子式: C51H63N11O4
- 分子量:894.12
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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5-HT1F Receptor 77.91 nM (IC50) |
ERK |
化学情報
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CAS 番号 2921670-99-5
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分子量 894.12
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分子式 C51H63N11O4
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SMILES
CN(CC1)CCC1C2=CNC3=CC=C(NC(C4=CC(C=C(C5CCN(C(N[C@H](CC6=CC(C)=C(NN=C7)C7=C6)C(N8CCN(C9CCN(C)CC9)CC8)=O)=O)CC5)C(N%10)=O)=C%10C=C4)=O)C=C32
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PCC0105005 関連分類
HY-179684 関連分類
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- PCC0105005
- 2921670-99-5
- PCC 0105005
- PCC-0105005
- CGRP Receptor
- 5-HT Receptor
- ERK
- Epigenetic Reader Domain
- Dual-target therapeutics
- CGRP antagonists
- 5-HT1F agonists
- migraine treatment
- structure-based drug design
- pharmacokinetics
- peripheral restriction
- trigeminovascular system
- neurogenic inflammation
- pain threshold
- Inhibitor
- inhibitor
- inhibit