rel-AZ5576
rel-AZ5576 is a selective CDK9 inhibitor with the activity of downregulating Mcl-1 and MYC mRNA transcription and protein expression in diffuse large B-cell lymphoma by inhibiting CDK9, promoting MYC protein turnover, reducing MYC phosphorylation on the stable Ser62 residue and downregulating MYC transcriptional targets, inhibiting the growth of diffuse large B-cell lymphoma cell lines in vitro and in vivo and independent of the cell origin.
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- CAS 番号: 1333468-05-5
- 分子式: C21H24FN3O3
- 分子量:385.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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CAS 番号 1333468-05-5
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分子量 385.43
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分子式 C21H24FN3O3
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SMILES
O=C([C@H]1C[C@@H](NC(C)=O)CCC1)NC2=NC=CC(C3=CC=C(F)C=C3OC)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
溶剤 & 溶解度
DMSO : 200 mg/mL (518.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
参考文献
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5945 mL | 12.9725 mL | 25.9450 mL | 64.8626 mL |
| 5 mM | 0.5189 mL | 2.5945 mL | 5.1890 mL | 12.9725 mL | |
| 10 mM | 0.2595 mL | 1.2973 mL | 2.5945 mL | 6.4863 mL | |
| 15 mM | 0.1730 mL | 0.8648 mL | 1.7297 mL | 4.3242 mL | |
| 20 mM | 0.1297 mL | 0.6486 mL | 1.2973 mL | 3.2431 mL | |
| 25 mM | 0.1038 mL | 0.5189 mL | 1.0378 mL | 2.5945 mL | |
| 30 mM | 0.0865 mL | 0.4324 mL | 0.8648 mL | 2.1621 mL | |
| 40 mM | 0.0649 mL | 0.3243 mL | 0.6486 mL | 1.6216 mL | |
| 50 mM | 0.0519 mL | 0.2595 mL | 0.5189 mL | 1.2973 mL | |
| 60 mM | 0.0432 mL | 0.2162 mL | 0.4324 mL | 1.0810 mL | |
| 80 mM | 0.0324 mL | 0.1622 mL | 0.3243 mL | 0.8108 mL | |
| 100 mM | 0.0259 mL | 0.1297 mL | 0.2595 mL | 0.6486 mL |
rel-AZ5576 関連分類
HY-111537 関連分類
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