TMX-2138
Based on 1 Customer Validation
(Pink: CDK ligand (HY-151071); Blue: Cereblon ligand (HY-14658); Black: linker (HY-W008352)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.99%
- CAS 番号: 2488892-07-3
- 分子式: C40H43BrFN9O11S
- 分子量:956.79
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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CDK1/cyclinB 8.7 nM (IC50) |
CDK2/cyclinA 10.9 nM (IC50) |
Cdk5/p25 7.0 nM (IC50) |
CDK9/cyclinT1 25.7 nM (IC50) |
CDK4/cyclinD1 901 nM (IC50) |
CDK6/cyclinD1 465 nM (IC50) |
CDK7/cyclin H 286 nM (IC50) |
TMX-2138 (10-point dose response) potently inhibits purified human CDK1/cyclin B (IC50 = 8.7 nM), CDK2/cyclin A (IC50 = 10.9 nM), CDK5/p25 (IC50 = 7.0 nM), and CDK9/cyclin T1 (IC50 = 25.7 nM), while showing much weaker activity against CDK4/cyclin D1, CDK6/cyclin D1, and CDK7/cyclin H/MNAT1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2488892-07-3
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性状 Solid
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分子量 956.79
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分子式 C40H43BrFN9O11S
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Color White to light yellow
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SMILES
O=C(C1=C(NC2=NC(NC3=CC=C(S(=O)(NCCOCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C=C3)=NC=C2Br)C=CC=C1F)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 100 mg/mL (104.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0452 mL | 5.2258 mL | 10.4516 mL | 26.1290 mL |
| 5 mM | 0.2090 mL | 1.0452 mL | 2.0903 mL | 5.2258 mL | |
| 10 mM | 0.1045 mL | 0.5226 mL | 1.0452 mL | 2.6129 mL | |
| 15 mM | 0.0697 mL | 0.3484 mL | 0.6968 mL | 1.7419 mL | |
| 20 mM | 0.0523 mL | 0.2613 mL | 0.5226 mL | 1.3065 mL | |
| 25 mM | 0.0418 mL | 0.2090 mL | 0.4181 mL | 1.0452 mL | |
| 30 mM | 0.0348 mL | 0.1742 mL | 0.3484 mL | 0.8710 mL | |
| 40 mM | 0.0261 mL | 0.1306 mL | 0.2613 mL | 0.6532 mL | |
| 50 mM | 0.0209 mL | 0.1045 mL | 0.2090 mL | 0.5226 mL | |
| 60 mM | 0.0174 mL | 0.0871 mL | 0.1742 mL | 0.4355 mL | |
| 80 mM | 0.0131 mL | 0.0653 mL | 0.1306 mL | 0.3266 mL | |
| 100 mM | 0.0105 mL | 0.0523 mL | 0.1045 mL | 0.2613 mL |
TMX-2138 関連分類
HY-164906 関連分類
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