Cat. No.: HY-10256

Adezmapimod

(Synonyms: SB 203580; RWJ 64809)

626 Cited Publications

고객리뷰

Based on 626 publication(s) in Google Scholar

Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator.

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Purity: 99.93%
CAS No.: 152121-47-6
화학식: C₂₁H₁₆FN₃OS
분자량:377.43

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Adezmapimod Chemical Structure

CAS No.: 152121-47-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (626)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

p38

50 nM (IC₅₀)

p38β2

500 nM (IC₅₀)

All p38 MAPK Isoforms :

All HSP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BMDC	IC₅₀	3.45 μM Compound: SB203580	Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA	[PMID: 23484668]
BMDC	IC₅₀	3.5 μM Compound: SB203580	Antiinflammatory activity in C57BL/6 mouse BMDC cells assessed as inhibition of LPS-induced IL-6 production preincubated for 1 hr prior to LPS-stimulation measured after 18 hrs by ELISA Antiinflammatory activity in C57BL/6 mouse BMDC cells assessed as inhibition of LPS-induced IL-6 production preincubated for 1 hr prior to LPS-stimulation measured after 18 hrs by ELISA	[PMID: 24047259]
BMDC	IC₅₀	3.5 μM Compound: SB203580	Anti-inflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-induced IL-6 production pretreated for 1 hr followed by LPS-stimulation after 18 hrs by ELISA Anti-inflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-induced IL-6 production pretreated for 1 hr followed by LPS-stimulation after 18 hrs by ELISA	[PMID: 28009172]
BMDC	IC₅₀	3.53 μM Compound: SB203580	Antiinflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated IL-6 production preincubated for 1 hr before LPS-stimulation measured after 16 hrs by ELISA Antiinflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated IL-6 production preincubated for 1 hr before LPS-stimulation measured after 16 hrs by ELISA	[PMID: 22071304]
BMDC	IC₅₀	3.56 μM Compound: SB203580	Antiinflammatory activity against in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated IL6 production compound pre-incubated for 1 hr before LPS challenge by ELISA Antiinflammatory activity against in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated IL6 production compound pre-incubated for 1 hr before LPS challenge by ELISA	[PMID: 23200246]
BMDC	IC₅₀	5 μM Compound: SB203580	Antiinflammatory activity in wild-type C57BL/6 mouse BMDCs assessed as inhibition of IL-12 p40 production incubated for 1 hr prior to LPS challenge measured after 16 hrs by ELISA Antiinflammatory activity in wild-type C57BL/6 mouse BMDCs assessed as inhibition of IL-12 p40 production incubated for 1 hr prior to LPS challenge measured after 16 hrs by ELISA	[PMID: 23395633]
BMDC	IC₅₀	5 μM Compound: SB203580	Antiinflammatory activity in C57BL/6 mouse BMDC cells assessed as inhibition of LPS-induced IL-12 p40 production preincubated for 1 hr prior to LPS-stimulation measured after 18 hrs by ELISA Antiinflammatory activity in C57BL/6 mouse BMDC cells assessed as inhibition of LPS-induced IL-12 p40 production preincubated for 1 hr prior to LPS-stimulation measured after 18 hrs by ELISA	[PMID: 24047259]
BMDC	IC₅₀	5 μM Compound: SB203580	Anti-inflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-induced IL12 p40 production pretreated for 1 hr followed by LPS-stimulation after 18 hrs by ELISA Anti-inflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-induced IL12 p40 production pretreated for 1 hr followed by LPS-stimulation after 18 hrs by ELISA	[PMID: 28009172]
BMDC	IC₅₀	5.02 μM Compound: SB203580	Antiinflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated IL-12p40 production preincubated for 1 hr before LPS-stimulation measured after 16 hrs by ELISA Antiinflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated IL-12p40 production preincubated for 1 hr before LPS-stimulation measured after 16 hrs by ELISA	[PMID: 22071304]
BMDC	IC₅₀	5.21 μM Compound: SB203580	Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA	[PMID: 23484668]
BMDC	IC₅₀	5.67 μM Compound: SB203580	Antiinflammatory activity against in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated IL12 production compound pre-incubated for 1 hr before LPS challenge by ELISA Antiinflammatory activity against in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated IL12 production compound pre-incubated for 1 hr before LPS challenge by ELISA	[PMID: 23200246]
BMDC	IC₅₀	7.2 μM Compound: SB203580	Anti-inflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-induced TNFalpha production pretreated for 1 hr followed by LPS-stimulation after 18 hrs by ELISA Anti-inflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-induced TNFalpha production pretreated for 1 hr followed by LPS-stimulation after 18 hrs by ELISA	[PMID: 28009172]
BMDC	IC₅₀	7.24 μM Compound: SB203580	Antiinflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated TNF-alpha production preincubated for 1 hr before LPS-stimulation measured after 16 hrs by ELISA Antiinflammatory activity in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated TNF-alpha production preincubated for 1 hr before LPS-stimulation measured after 16 hrs by ELISA	[PMID: 22071304]
BMDC	IC₅₀	7.37 μM Compound: SB203580	Antiinflammatory activity against in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated TNFalpha production compound pre-incubated for 1 hr before LPS challenge by ELISA Antiinflammatory activity against in C57BL/6 mouse BMDC assessed as inhibition of LPS-stimulated TNFalpha production compound pre-incubated for 1 hr before LPS challenge by ELISA	[PMID: 23200246]
BMDC	IC₅₀	7.5 μM Compound: SB203580	Antiinflammatory activity in C57BL/6 mouse BMDC cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 1 hr prior to LPS-stimulation measured after 18 hrs by ELISA Antiinflammatory activity in C57BL/6 mouse BMDC cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 1 hr prior to LPS-stimulation measured after 18 hrs by ELISA	[PMID: 24047259]
BMDC	IC₅₀	7.53 μM Compound: SB203580	Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA	[PMID: 23484668]
HEK293	EC₅₀	0.06 μM Compound: SB 203580	Inhibition of recombinant Nanoluc-tagged p38alpha (unknown origin) expressed in HEK293 cells incubated for 2 to 3 mins by NanoBRET assay Inhibition of recombinant Nanoluc-tagged p38alpha (unknown origin) expressed in HEK293 cells incubated for 2 to 3 mins by NanoBRET assay	[PMID: 31520926]
HEK293	IC₅₀	250 nM Compound: 2; SB-203580	Inhibition of RIP2K in MDP-stimulated HEK-293 cells over-expressing NOD2 assessed as IL8 secretion Inhibition of RIP2K in MDP-stimulated HEK-293 cells over-expressing NOD2 assessed as IL8 secretion	[PMID: 27109867]
HEK293	IC₅₀	6310 nM Compound: 2; SB-203580	Inhibition of RIP2K in Pam2CSK4-stimulated HEK-293 cells over-expressing TLR2 assessed as IL8 secretion Inhibition of RIP2K in Pam2CSK4-stimulated HEK-293 cells over-expressing TLR2 assessed as IL8 secretion	[PMID: 27109867]
HeLa	IC₅₀	0.1 μM Compound: SB-203580	Inhibition of Tat-induced HIV1 LTR transactivation in human HeLa cells assessed as CAT expression after 2 days Inhibition of Tat-induced HIV1 LTR transactivation in human HeLa cells assessed as CAT expression after 2 days	[PMID: 18926711]
HL-60	IC₅₀	50.5 μM Compound: SB-203580	Antiinflammatory activity in PMA-stimulated human HL60 cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins before LPS challenge measured after 24 hrs by ELISA Antiinflammatory activity in PMA-stimulated human HL60 cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins before LPS challenge measured after 24 hrs by ELISA	[PMID: 22621841]
HL-60	IC₅₀	52.2 μM Compound: SB203580	Antiinflammatory activity in human HL-60 derived macrophage-like cells assessed as inhibition of LPS-induced IL-6 production treated 30 mins before LPS stimulation measured after 24 hrs by ELISA Antiinflammatory activity in human HL-60 derived macrophage-like cells assessed as inhibition of LPS-induced IL-6 production treated 30 mins before LPS stimulation measured after 24 hrs by ELISA	[PMID: 23811089]
HL-60	IC₅₀	52.2 μM Compound: SB-203580	Antiinflammatory activity in PMA-stimulated human HL60 cells assessed as inhibition of LPS-induced IL-6 production preincubated for 30 mins before LPS challenge measured after 24 hrs by ELISA Antiinflammatory activity in PMA-stimulated human HL60 cells assessed as inhibition of LPS-induced IL-6 production preincubated for 30 mins before LPS challenge measured after 24 hrs by ELISA	[PMID: 22621841]
HL-60	IC₅₀	8.6 μM Compound: SB203580	Antiinflammatory activity in human HL-60 derived macrophage-like cells assessed as inhibition of LPS-induced TNFalpha production treated 30 mins before LPS stimulation measured after 24 hrs by ELISA Antiinflammatory activity in human HL-60 derived macrophage-like cells assessed as inhibition of LPS-induced TNFalpha production treated 30 mins before LPS stimulation measured after 24 hrs by ELISA	[PMID: 23811089]
L132	CC₅₀	>10 μM Compound: 81; SB203580	Cytotoxicity against human L132 cells Cytotoxicity against human L132 cells	[PMID: 33539089]
PBMC	IC₅₀	>10 μM Compound: SB-203580	Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced IL6 release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced IL6 release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay	[PMID: 23411072]
PBMC	IC₅₀	0.34 μM Compound: SB-203580	Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced IL1-beta release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced IL1-beta release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay	[PMID: 23411072]
PBMC	IC₅₀	1 μM Compound: SB-203580	Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced TNFalpha release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced TNFalpha release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay	[PMID: 23411072]
PBMC	IC₅₀	160 nM Compound: 4	Inhibition of staphylococcal enterotoxin B(SEB) stimulated tumor necrosis factor alpha (TNF-alpha) production by human peripheral blood mononuclear cells(PBMCs) Inhibition of staphylococcal enterotoxin B(SEB) stimulated tumor necrosis factor alpha (TNF-alpha) production by human peripheral blood mononuclear cells(PBMCs)	[PMID: 9784093]
PBMC	IC₅₀	25 nM Compound: 4	Inhibition of LPS-stimulated TH+NF-alphs production by human peripheral blood mononuclear cells (PBMCs) Inhibition of LPS-stimulated TH+NF-alphs production by human peripheral blood mononuclear cells (PBMCs)	[PMID: 9784093]
PBMC	IC₅₀	48 nM Compound: 4	Inhibition of LPS-induced IL1-beta production in human peripheral blood mononuclear cells(PBMCs) Inhibition of LPS-induced IL1-beta production in human peripheral blood mononuclear cells(PBMCs)	[PMID: 9784093]
Peritoneal macrophage cell	IC₅₀	0.22 μM Compound: 10, SB-203580	Antiinflammatory activity in BALB/c mouse peritoneal macrophages assessed as inhibition of LPS-induced TNFalpha production treated 1 hr before LPS challenge measured after 24 hrs by ELISA Antiinflammatory activity in BALB/c mouse peritoneal macrophages assessed as inhibition of LPS-induced TNFalpha production treated 1 hr before LPS challenge measured after 24 hrs by ELISA	[PMID: 22647219]
Platelet	IC₅₀	200 nM Compound: K00038	Inhibition of collagen-induced human platelet aggregation Inhibition of collagen-induced human platelet aggregation	[PMID: 18077363]
RBL-1	IC₅₀	58 μM Compound: 2	Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells	10.1016/0960-894X(95)00189-Z
Sf9	IC₅₀	0.035 μM Compound: SB203580	Inhibition of recombinant human full-length N-terminal GST-tagged P38 alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins in presen Inhibition of recombinant human full-length N-terminal GST-tagged P38 alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins in presen	[PMID: 31445234]
Sf9	IC₅₀	10 nM Compound: 2, SB-203580	Inhibition of full-length FLAG-6His-TEV tagged human RIP2 expressed in Sf9 cells assessed as reduction in autophosphorylation pre-incubated for 30 mins followed by incubation with ATP for 2 hrs by ADP-Glo assay Inhibition of full-length FLAG-6His-TEV tagged human RIP2 expressed in Sf9 cells assessed as reduction in autophosphorylation pre-incubated for 30 mins followed by incubation with ATP for 2 hrs by ADP-Glo assay	[PMID: 26455654]
Sf9	IC₅₀	200 nM Compound: 2, SB-203580	Inhibition of full-length FLAG-6His-TEV tagged human RIP2 expressed in Sf9 cells by fluorescent polarization assay Inhibition of full-length FLAG-6His-TEV tagged human RIP2 expressed in Sf9 cells by fluorescent polarization assay	[PMID: 26455654]
SW1353	IC₅₀	0.05 μM Compound: 1	Compound was evaluated for its ability to inhibit IL-6 production in SW1353 cells treated with cytokines IL-1 and TNF Compound was evaluated for its ability to inhibit IL-6 production in SW1353 cells treated with cytokines IL-1 and TNF	[PMID: 10999467]
SW1353	IC₅₀	50 nM Compound: 1	Inhibition of IL-6 production by SW1353 cells treated with both cytokines IL-1 and TNF-alpha. Inhibition of IL-6 production by SW1353 cells treated with both cytokines IL-1 and TNF-alpha.	[PMID: 11140741]
SW1353	IC₅₀	50 nM Compound: 1	Inhibition of TNF and IL-1 induced IL-6 production in human chondro-sarcoma SW 1353 cells Inhibition of TNF and IL-1 induced IL-6 production in human chondro-sarcoma SW 1353 cells	[PMID: 10999468]
THP-1	EC₅₀	60 nM Compound: 1	Inhibition of LPS-induced tumor necrosis factor-alpha (TNF-alpha) production in THP-1 cells Inhibition of LPS-induced tumor necrosis factor-alpha (TNF-alpha) production in THP-1 cells	[PMID: 12086485]
THP-1	IC₅₀	0.016 μM Compound: SB-203580	Inhibition of LPS-induced TNFalpha production in human THP1 cells Inhibition of LPS-induced TNFalpha production in human THP1 cells	[PMID: 18325768]
THP-1	IC₅₀	0.07 μM Compound: SB-203580	Inhibition of tumor necrosis factor alpha release by THP-1 cells Inhibition of tumor necrosis factor alpha release by THP-1 cells	[PMID: 15658855]
THP-1	IC₅₀	20 nM Compound: SB 203580	Inhibition of LPS-induced TNFalpha production in human THP1 cells incubated for 1 hr followed by LPS stimulation and measured after 4 hrs by TR-FRET method Inhibition of LPS-induced TNFalpha production in human THP1 cells incubated for 1 hr followed by LPS stimulation and measured after 4 hrs by TR-FRET method	[PMID: 31520926]
THP-1	IC₅₀	50 nM Compound: K00038	Inhibition of LPS-stimulated IL1 production in human THP1 cells Inhibition of LPS-stimulated IL1 production in human THP1 cells	[PMID: 18077363]
THP-1	IC₅₀	50 nM Compound: K00038	Inhibition of LPS-stimulated TNFalpha production in human THP1 cells Inhibition of LPS-stimulated TNFalpha production in human THP1 cells	[PMID: 18077363]
THP-1	IC₅₀	72 nM Compound: SB-203580	Inhibitory activity against TNF-alpha production using lipopolysaccharide stimulated human monocytic cells Inhibitory activity against TNF-alpha production using lipopolysaccharide stimulated human monocytic cells	[PMID: 12729637]
THP-1	IC₅₀	72 nM Compound: SB-203580	Inhibitory activity against LPS-stimulated TNF-alpha production in human monocytic cells (THP-1) Inhibitory activity against LPS-stimulated TNF-alpha production in human monocytic cells (THP-1)	[PMID: 15139749]
THP-1	IC₅₀	72 nM Compound: SB-203580	Inhibitory activity against lipopolysaccharide stimulated TNF-alpha production in THP-1 cells (human monocytic cells) Inhibitory activity against lipopolysaccharide stimulated TNF-alpha production in THP-1 cells (human monocytic cells)	[PMID: 15837310]
THP-1	IC₅₀	72 nM Compound: SB-203580	Inhibition of LPS-stimulated TNFalpha production in THP1 cells Inhibition of LPS-stimulated TNFalpha production in THP1 cells	[PMID: 16750367]
THP-1	IC₅₀	72 μM Compound: SB-203580	Concentration required to inhibit production of Tumor necrosis factor, alpha in LPS-stimulated human monocytic cells (THP-1) Concentration required to inhibit production of Tumor necrosis factor, alpha in LPS-stimulated human monocytic cells (THP-1)	[PMID: 15341957]

In Vitro

Adezmapimod (SB 203580) (preincubated with 0-30 μM for 1 h and cultured for 24 h in the presence of 20 ng/mL IL-2) prevents the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC₅₀ of 3-5 μM^[1].
SB203580 blocks PKB phosphorylation (IC₅₀ 3-5 μM). SB203580 inhibitsthe phosphorylation of Ser473 in a dose-dependent manner in both CT6 and activated human T cells and IL-2-responsive BA/F3 F7 B cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

CT6, BA/F3 cell line F7, and PBMC/T cells
Concentration:

0-30 μM
Incubation Time:

Preincubated with 0-30 μM SB203580 for 1 h and cultured for 24 h in the presence of 20 ng/mL IL-2
Result:

Prevented the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC₅₀ of 3-5 μM.

Western Blot Analysis^[1]

Cell Line:

CT6 cells, activated human T cells, and BA/F3 F7 cells
Concentration:

0-30 μM
Incubation Time:

Preincubated with 0-30 μM SB203580 for 1 h before stimulating with 20 ng/mL IL-2 for 5 min
Result:

Inhibited the phosphorylation of PKB at Ser473 in a dose-dependent manner.

In Vivo

Adezmapimod (SB 203580) (5 mg/kg/day; intra peritoneal injected daily for 16 consecutive days, in female atymic Nu/Nu mice) treatment, p38WT tumors show a significantly smaller tumor burden when compared with p38TM tumors that were treated in parallel^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Six-week-old female atymic Nu/Nu mice CAL27 p38WT and p38TM tumors^[1]
Dosage:

5 mg/kg/day
Administration:

Intra peritoneal injected daily for 16 consecutive days
Result:

After 2 weeks treatment, CAL27 p38WT tumors were significantly smaller; CAL27 p38TM tumors were not affected by the p38 inhibitor (n=10).

Chemical Information

CAS No. 152121-47-6
Appearance Solid
분자량 377.43
화학식 C₂₁H₁₆FN₃OS
Color White to light yellow
SMILES

O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C
Synonyms

SB 203580; RWJ 64809
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (626)

All IFWBIHCRT-PCR

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Journal Impact Factor

Signal Transduct Target Ther

Dihydroartemisinin regulates immune cell heterogeneity by triggering a cascade reaction of CDK and MAPK phosphorylation. [Abstract]

2022 Jul 11;7(1):222. PMID: 35811310
Signal Transduct Target Ther

TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway. [Abstract]

2020 Aug 25;5(1):163. PMID: 32843639
Cell Res

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. [Abstract]

2020 Jul;30(7):574-589. PMID: 32341413
Cancer Commun (Lond)

The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells. [Abstract]

2021 Jan;41(1):62-78. PMID: 34236149

Adezmapimod purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Jan;41(1):62-78. [Abstract]

Cells pre-treated with P38 inhibitor SB203580 (SB2, 10 μmol/L) for 6 h were further stimulated with EGF (20 ng/mL) for 24 h, then PD-L1 and HLA-B transcription was detected by qRT-PCR.

Adezmapimod purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Jan;41(1):62-78. [Abstract]

Cells pre-treated with P38 inhibitor SB203580 (SB2, 10 μmol/L) for 6 h were further stimulated with EGF (20 ng/mL) for 24 h, then PD-L1 and HLA-ABC protein levels were measured by Western blotting.

Adezmapimod purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2021 Jan;41(1):62-78. [Abstract]

Cells were pre-treated with SB203580 (Adezmapimod) (10 μmol/L) or dimethylsulfoxide (DMSO) for 6 h, and then co-stimulated with or without EGF for an additional 24 h, next cells were further treated with actinomycin D (5 μg/mL) for 0-120 min, and cellular PD-L1 mRNA expression was detected by qRT-PCR.
Nat Cancer

MEF2D-expressing cancer precursors reprogram tissue-resident macrophages to support liver tumorigenesis. [Abstract]

2025 Dec;6(12):1955-1975. PMID: 41131393
Nat Metab

Activation of GPR81 by lactate drives tumour-induced cachexia. [Abstract]

2024 Apr;6(4):708-723. PMID: 38499763
Nat Metab

The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress. [Abstract]

2021 Oct;3(10):1357-1371. PMID: 34663976
Nat Immunol

The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity. [Abstract]

2023 Nov;24(11):1813-1824. PMID: 37813965
Cell Mol Immunol

γδ+ T-cell-derived IL-17A stimulates airway epithelial/stromal cells to secrete G-CSF, promoting lung-specific pathogenic Siglec-F+ neutrophil development in PPE-induced emphysema. [Abstract]

2025 Jul;22(7):791-805. PMID: 40461699
Cell Mol Immunol

β-adrenoreceptor-triggered PKA activation negatively regulates the innate antiviral response. [Abstract]

2023 Feb;20(2):175-188. PMID: 36600052
Cell Mol Immunol

Serine metabolism orchestrates macrophage polarization by regulating the IGF1-p38 axis. [Abstract]

2022 Nov;19(11):1263-1278. PMID: 36180780
Bioact Mater

Food-derived β-lactoglobulin nanofibrils: An efficacy, safe, and scalable solution to overcome oral insulin delivery challenges. [Abstract]

2025 Nov 25:57:646-659. PMID: 41377894
Cancer Res

Thymosin α-1 Reverses M2 Polarization of Tumor-Associated Macrophages during Efferocytosis. [Abstract]

2022 May 16;82(10):1991-2002. PMID: 35364609
Clin Mol Hepatol

Taurocholic Acid Promotes Hepatic Stellate Cell Activation via S1PR2/p38 MAPK/YAP Signaling under Cholestatic Conditions. [Abstract]

2023 Apr;29(2):465-481. PMID: 36800698
Autophagy

Dysfunctional autophagy triggers STING1 activation to exacerbate cartilage degeneration in obesity-associated osteoarthritis. [Abstract]

2025 Dec;21(12):3344-3360. PMID: 40728163
Autophagy

Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. [Abstract]

2021 Nov;17(11):3592-3606. PMID: 33629929
Autophagy

Manipulation of Mitophagy by "All-in-One" nanosensitizer augments sonodynamic glioma therapy. [Abstract]

2020 Aug;16(8):1413-1435. PMID: 31674265
Protein Cell

Chemical genomics reveals inhibition of breast cancer lung metastasis by Ponatinib via c-Jun. [Abstract]

2019 Mar;10(3):161-177. PMID: 29667003
Nat Commun

Josephin Domain Containing 2 (JOSD2) inhibition as Pan-KRAS-mutation-targeting strategy for colorectal cancer. [Abstract]

2025 Apr 16;16(1):3623. PMID: 40240366
Nat Commun

Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma. [Abstract]

2025 Mar 15;16(1):2565. PMID: 40089475
Nat Commun

Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in pancreatic cancer. [Abstract]

2024 Oct 2;15(1):8540. PMID: 39358362
Nat Commun

Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion. [Abstract]

2024 Apr 11;15(1):3165. PMID: 38605010
Nat Commun

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1. [Abstract]

2018 Apr 30;9(1):1723. PMID: 29712904
Hepatology

Eosinophils protect against acetaminophen-induced liver injury through cyclooxygenase-mediated IL-4/IL-13 production. [Abstract]

2023 Feb 1;77(2):456-465. PMID: 35714036
J Adv Res

IFITM3 knockout alleviates neuronal parthanatos by restoring astrocytic glutamate uptake in intracerebral hemorrhage mice. [Abstract]

2026 May 16:S2090-1232(26)00437-6. PMID: 42144055
Cell Discov

ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression. [Abstract]

2026 Feb 24;12(1):13. PMID: 41730846
Sci Immunol

SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors. [Abstract]

2022 Jan 21;7(67):eabj5501. PMID: 35061505
Redox Biol

PP4 modulates macrophage-neutrophil crosstalk to restrict CCL5 -driven NETosis in sepsis. [Abstract]

2026 Apr:91:104093. PMID: 41723906
Redox Biol

Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress. [Abstract]

2023 Feb:59:102594. PMID: 36603528
Redox Biol

Chenodeoxycholic acid suppresses AML progression through promoting lipid peroxidation via ROS/p38 MAPK/DGAT1 pathway and inhibiting M2 macrophage polarization. [Abstract]

2022 Oct:56:102452. PMID: 36084349
Mol Cell

HSPA1A and DNAJB1 regulate NELF condensate dynamics to safeguard transcriptional recovery under heat stress. [Abstract]

2026 Feb 19;86(4):674-692.e10. PMID: 41653920
Mol Cell

PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia. [Abstract]

2020 Jan 2;77(1):95-107.e5. PMID: 31628042
J Nanobiotechnology

A fibrin gel-loaded Gouqi-derived nanovesicle (GqDNV) repairs the heart after myocardial infarction by inhibiting p38 MAPK/NF-κB p65 pathway. [Abstract]

2025 Jul 22;23(1):535. PMID: 40696398
J Nanobiotechnology

Metal-organic framework materials promote neural differentiation of dental pulp stem cells in spinal cord injury. [Abstract]

2023 Sep 4;21(1):316. PMID: 37667307
J Nanobiotechnology

In situ construction of flower-like nanostructured calcium silicate bioceramics for enhancing bone regeneration mediated via FAK/p38 signaling pathway. [Abstract]

2022 Mar 27;20(1):162. PMID: 35351145
Acta Pharm Sin B

2025 Dec 29.
Genes Dis

2025 Nov 6.
Acta Pharm Sin B

Semi-synthetic chondroitin sulfate CS-semi5 upregulates miR-122-5p, conferring a therapeutic effect on osteoarthritis via the p38/MMP13 pathway. [Abstract]

2024 Aug;14(8):3528-3542. PMID: 39220883
Acta Pharm Sin B

A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis. [Abstract]

2023 Feb;13(2):722-738. PMID: 36873181
J Biomed Sci

Fusobacterium nucleatum promotes colorectal cancer liver metastasis via miR-5692a/IL-8 axis by inducing epithelial-mesenchymal transition. [Abstract]

2025 Jan 6;32(1):5. PMID: 39757156
J Exp Clin Cancer Res

Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling. [Abstract]

2025 Aug 27;44(1):255. PMID: 40866941
J Exp Clin Cancer Res

RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer. [Abstract]

2022 Dec 29;41(1):364. PMID: 36581998
J Exp Clin Cancer Res

HGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma metastasis through upregulating PTK2 and c-MET. [Abstract]

2022 Sep 16;41(1):275. PMID: 36109787
Adv Sci (Weinh)

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment. [Abstract]

2026 Mar 20:e16557. PMID: 41861091
Adv Sci (Weinh)

Single-Nucleus Multi-Omics Reveals Hypoxia-Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma. [Abstract]

2026 Feb;13(12):e10302. PMID: 41498635
Adv Sci (Weinh)

Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by β-Adrenergic Activation. [Abstract]

2025 Mar;12(12):e2413324. PMID: 39921269
Adv Sci (Weinh)

The Gut Microbiota Affects Anti-TNF Responsiveness by Activating the NAD+ Salvage Pathway in Ulcerative Colitis. [Abstract]

2025 Feb;12(8):e2413128. PMID: 39739648
Adv Sci (Weinh)

EPO Deficiency Upregulates GADD45b/p38 MAPK Axis, Mediating Schizophrenia-Related Synaptic and Cognitive Impairments. [Abstract]

2024 Dec;11(47):e2406979. PMID: 39467064
MedComm

Identification of circulating T-cell immunoglobulin and mucin domain 4 as a potential biomarker for coronary heart disease. [Abstract]

2023 Jul 8;4(4):e320. PMID: 37426678
Cell Rep Med

Fungal metabolite-based immunotherapy overcomes tumor-associated macrophage immunosuppression. [Abstract]

2026 Jun 16;7(6):102833. PMID: 42173096
Cell Rep Med

MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1. [Abstract]

2025 Feb 18;6(2):101922. PMID: 39842432
Cell Rep Med

Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer. [Abstract]

2024 Feb 20;5(2):101388. PMID: 38262412
Sci Adv

Neuronal Reg3β/macrophage TNF-α-mediated positive feedback signaling contributes to pain chronicity in a rat model of CRPS-I. [Abstract]

2025 Aug;11(31):eadu4270. PMID: 40749060
Biomaterials

FAK-p38 signaling serves as a potential target for reverting matrix stiffness-modulated liver sinusoidal endothelial cell defenestration. [Abstract]

2024 Mar:305:122462. PMID: 38171118
Cell Death Differ

Deubiquitinating enzyme USP33 restrains docetaxel-induced apoptosis via stabilising the phosphatase DUSP1 in prostate cancer. [Abstract]

2020 Jun;27(6):1938-1951. PMID: 31857702
Cell Death Differ

E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation. [Abstract]

2019 Nov;26(11):2386-2399. PMID: 30816303
Biomaterials

Gold and gold-silver alloy nanoparticles enhance the myogenic differentiation of myoblasts through p38 MAPK signaling pathway and promote in vivo skeletal muscle regeneration. [Abstract]

2018 Aug:175:19-29. PMID: 29793089

Adezmapimod purchased from MedChemExpress. Usage Cited in: Biomaterials. 2018 Aug:175:19-29. [Abstract]

Western blotting analysis showing the related protein expression (MHC, MyoD, p38α, phospho-p38α) of C2C12 myoblasts after incubated for 6 days in DM containing 40 μg/mL AuNPs and Au-AgNPs in the presence or absence of SB203580 (SB).
Cell Death Differ

A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses. [Abstract]

2017 Mar;24(3):492-499. PMID: 28009352

Adezmapimod purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2017 Mar;24(3):492-499. [Abstract]

LPS stimulates ICER expression via p38-CREB pathway. Effect of MAPK and IKK inhibitors on LPS-induced CREB phosphorylation in peritoneal macrophages.
Carbohydr Polym

Polysaccharide enhanced NK cell cytotoxicity against pancreatic cancer via TLR4/MAPKs/NF-κB pathway in vitro/vivo. [Abstract]

2019 Dec 1;225:115223. PMID: 31521276
Research (Wash D C)

Gene Signature-Based Drug Screening Reveals Ponatinib Enhances Immunotherapy Efficacy in Triple-Negative Breast Cancer by Reversing MDSC-Mediated Immunosuppressive Tumor Microenvironment. [Abstract]

2025 Oct 9:8:0915. PMID: 41079672
Cell Death Dis

The E3 ligase TRIM29 drives renal ischemia-reperfusion injury by targeting DUSP10 for proteasomal degradation. [Abstract]

2026 Jun 13. PMID: 42288472
Cell Death Dis

STUB1-induced polyubiquitination of SIK3 in alveolar type 2 epithelial cells alleviates severity and outcomes of acute lung injury. [Abstract]

2026 May 4;17(1):589. PMID: 42082453
Pharmacol Res

The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy. [Abstract]

2025 Jun:216:107763. PMID: 40339965
Cell Mol Biol Lett

Narciclasine enhances cisplatin-induced apoptotic cell death by inducing unfolded protein response-mediated regulation of NOXA and MCL1. [Abstract]

2025 May 14;30(1):59. PMID: 40369444
Cell Death Dis

UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia. [Abstract]

2025 Apr 29;16(1):351. PMID: 40301374
Cell Death Dis

LINC00924-induced fatty acid metabolic reprogramming facilitates gastric cancer peritoneal metastasis via hnRNPC-regulated alternative splicing of Mnk2. [Abstract]

2022 Nov 23;13(11):987. PMID: 36418856
Cell Death Dis

Inhibition of p38 MAPK or immunoproteasome overcomes resistance of chronic lymphocytic leukemia cells to Bcl-2 antagonist venetoclax. [Abstract]

2022 Oct 8;13(10):860. PMID: 36209148
Cell Death Dis

Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition. [Abstract]

2022 Jul 15;13(7):615. PMID: 35840557
Cell Death Dis

ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY. [Abstract]

2021 Nov 27;12(12):1113. PMID: 34839358
Cell Death Dis

Effects of short-chain fatty acids in inhibiting HDAC and activating p38 MAPK are critical for promoting B10 cell generation and function. [Abstract]

2021 Jun 7;12(6):582. PMID: 34099635
Cell Death Dis

SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells. [Abstract]

2021 Jun 2;12(6):570. PMID: 34108444
Cell Death Dis

C1q-TNF-related protein-3 attenuates pressure overload-induced cardiac hypertrophy by suppressing the p38/CREB pathway and p38-induced ER stress. [Abstract]

2019 Jul 8;10(7):520. PMID: 31285424
Cell Death Dis

β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma. [Abstract]

2019 Mar 15;10(4):255. PMID: 30874538
Pharmacol Res

Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia. [Abstract]

2018 Jul:133:218-235. PMID: 29391237
Cell Death Dis

Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice. [Abstract]

2016 Jun 23;7(6):e2273. PMID: 27336717
Cancer Lett

Targeting MKK3/c-Myc interaction to overcome osimertinib acquired resistance in EGFR mutant lung cancer. [Abstract]

2025 Aug 29:633:218010. PMID: 40886822
Cancer Lett

VCPA, a novel synthetic derivative of α-tocopheryl succinate, sensitizes human gastric cancer to doxorubicin-induced apoptosis via ROS-dependent mitochondrial dysfunction. [Abstract]

2017 May 1:393:22-32. PMID: 28216375

Adezmapimod purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2017 May 1:393:22-32. [Abstract]

Effects of p38 MAPK inhibitor (SB203580), ERK inhibitor (U0126), JNK inhibitor (SP600125), caspase inhibitor (Z-VAD-FMK) and NAC on SGC-7901 and MGC-803 treated with DOX/VCPA combination treatment. VCPA pretreatment strategy is the same as above. SB203580 (20 μM), U0126 (10 μM), SP600125 (20 μM), Z-VAD-FMK (10 μM) and NAC (5 mM) are treated 2 h before DOX (2 μg/mL) added into the culture, respectively. MAPK pathway protein levels are determined.
J Immunother Cancer

Targeting CD93 on monocytes revitalizes antitumor immunity by enhancing the function and infiltration of CD8+ T cells. [Abstract]

2024 Oct 23;12(10):e010148. PMID: 39448202
Int J Biol Sci

Hypoxia-induced exosomes facilitate lung pre-metastatic niche formation in hepatocellular carcinoma through the miR-4508-RFX1-IL17A-p38 MAPK-NF-κB pathway. [Abstract]

2023 Sep 4;19(15):4744-4762. PMID: 37781522
Int J Biol Sci

Gamma synuclein promotes cancer metastasis through the MKK3/6-p38MAPK cascade. [Abstract]

2022 May 1;18(8):3167-3177. PMID: 35637967
J Immunother Cancer

Tumor-released autophagosomes induces CD4+ T cell-mediated immunosuppression via a TLR2-IL-6 cascade. [Abstract]

2019 Jul 12;7(1):178. PMID: 31300052
J Immunother Cancer

Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1. [Abstract]

2018 Dec 18;6(1):151. PMID: 30563569
Cell Commun Signal

Targeting the ERK1/2 and p38 MAPK pathways attenuates Golgi tethering factor golgin-97 depletion-induced cancer progression in breast cancer. [Abstract]

2025 Jan 13;23(1):22. PMID: 39800687
Cell Commun Signal

Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis. [Abstract]

2025 Jan 8;23(1):14. PMID: 39780180
Cell Commun Signal

Interleukin-22 receptor 1-mediated stimulation of T-type Ca2+ channels enhances sensory neuronal excitability through the tyrosine-protein kinase Lyn-dependent PKA pathway. [Abstract]

2024 Jun 3;22(1):307. PMID: 38831315
Cell Commun Signal

Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression. [Abstract]

2024 Feb 12;22(1):115. PMID: 38347536
Cell Commun Signal

Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension. [Abstract]

2021 Oct 11;19(1):103. PMID: 34635097
J Neuroinflammation

Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway. [Abstract]

2024 Aug 2;21(1):192. PMID: 39095838
J Neuroinflammation

The microRNA-211-5p/P2RX7/ERK/GPX4 axis regulates epilepsy-associated neuronal ferroptosis and oxidative stress. [Abstract]

2024 Jan 8;21(1):13. PMID: 38191407
J Neuroinflammation

Hippocampal microRNA-26a-3p deficit contributes to neuroinflammation and behavioral disorders via p38 MAPK signaling pathway in rats. [Abstract]

2022 Nov 24;19(1):283. PMID: 36434679
J Neuroinflammation

Regulatory coupling between long noncoding RNAs and senescence in irradiated microglia. [Abstract]

2020 Oct 28;17(1):321. PMID: 33109221
J Neuroinflammation

JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss. [Abstract]

2018 Jun 15;15(1):184. PMID: 29907159

Adezmapimod purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2018 Jun 15;15(1):184. [Abstract]

Representative immunoblots of total lysates from BV2 cells treated with MPP+or/and U0126 (10 μM), SP600125 (SP, 10 μM) and SB203580 (SB, 10 μM) using the antibodies against DICER.
Phytomedicine

Network pharmacology and experimental validation of inflammation inhibition by ChuanKeZhi Injection in treating asthma. [Abstract]

2025 Jul 25:143:156891. PMID: 40450983
Phytomedicine

Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway. [Abstract]

2024 Dec:135:156052. PMID: 39383631
Phytomedicine

Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways. [Abstract]

2022 Apr:98:153928. PMID: 35104760
Phytomedicine

In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit. [Abstract]

2021 Mar:83:153479. PMID: 33561764
Phytomedicine

Gambogenic acid induces Noxa-mediated apoptosis in colorectal cancer through ROS-dependent activation of IRE1α/JNK. [Abstract]

2020 Nov:78:153306. PMID: 32854039
Phytomedicine

Timosaponin AIII attenuates inflammatory injury in AGEs-induced osteoblast and alloxan-induced diabetic osteoporosis zebrafish by modulating the RAGE/MAPK signaling pathways. [Abstract]

2020 Aug 15:75:153247. PMID: 32502823
Phytomedicine

Sweroside promotes osteoblastic differentiation and mineralization via interaction of membrane estrogen receptor-α and GPR30 mediated p38 signalling pathway on MC3T3-E1 cells. [Abstract]

2020 Mar:68:153146. PMID: 32028183
Phytomedicine

Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells. [Abstract]

2018 Mar 15:42:152-163. PMID: 29655681

Adezmapimod purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2018 Mar 15:42:152-163. [Abstract]

Cells are pretreated with SP600125 (20 μM), SB203580 (20 μM) or U0126 (20 μM) in presence or absence of KLA, then incubated with LPS (1 μg/mL) for certain time. Cell lysates are subjected to western blot.
Chin Herb Med

Taxifolin attenuates inflammation via suppressing MAPK signal pathway in vitro and in silico analysis. [Abstract]

2022 Sep 1;14(4):554-562. PMID: 36405054
Adv Healthc Mater

Clinical-Inspired Design of Self-Assembled Albumin-CeO2 Nanozymes for Oxygen-Self-Sufficient and Targeted Sonodynamic-Chemotherapy in Triple-Negative Breast Cancer. [Abstract]

2025 Dec 26:e04479. PMID: 41454512
Arch Toxicol

The tick saliva peptide HIDfsin2 promotes the tick-borne virus SFTSV replication in vitro by enhancing p38 signal pathway. [Abstract]

2023 Jun;97(6):1783-1794. PMID: 37148319
J Hazard Mater

Antimony induces oxidative stress to impair enteroendocrine cells and disrupt glucose homeostasis. [Abstract]

2026 Jan 1:501:140617. PMID: 41337963
Acta Pharmacol Sin

Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation. [Abstract]

2025 Jun 11. PMID: 40500345
Cell Death Discov

Decreased miR-128-3p in serum exosomes from polycystic ovary syndrome induces ferroptosis in granulosa cells via the p38/JNK/SLC7A11 axis through targeting CSF1. [Abstract]

2025 Feb 18;11(1):64. PMID: 39966422
Acta Pharmacol Sin

The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell-cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway. [Abstract]

2022 Sep;43(9):2289-2301. PMID: 35132192
Cell Death Discov

Pristimerin induces apoptosis and autophagy via activation of ROS/ASK1/JNK pathway in human breast cancer in vitro and in vivo. [Abstract]

2019 Aug 5:5:125. PMID: 31396402
Acta Pharmacol Sin

Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways. [Abstract]

2017 Aug;38(8):1120-1128. PMID: 28603288
Environ Int

Low-level contamination of deoxynivalenol: A threat from environmental toxins to porcine epidemic diarrhea virus infection. [Abstract]

2020 Oct:143:105949. PMID: 32673909
J Orthop Translat

Inhibiting the REV-ERBα expression protects against mechanical overloading-induced cartilage clock disruption and osteoarthritis progression. [Abstract]

2025 Jun 18:53:112-125. PMID: 40606845
J Transl Med

The protective role of microRNA-21 against coxsackievirus B3 infection through targeting the MAP2K3/P38 MAPK signaling pathway. [Abstract]

2019 Oct 4;17(1):335. PMID: 31585536
Proc Natl Acad Sci U S A

Metabolic stress conditions dictate MAPKAPK2-dependent efficiency of MEK1/2 inhibition in colorectal carcinoma. [Abstract]

2026 Feb 17;123(7):e2505331123. PMID: 41662531
Genome Biol

The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model. [Abstract]

2023 Feb 1;24(1):20. PMID: 36726140
Food Chem X

Immunoregulatory activity of a low-molecular-weight heteropolysaccharide from Ganoderma leucocontextum fruiting bodies in vitro and in vivo. [Abstract]

2022 Apr 30;14:100321. PMID: 35571333
Food Chem X

Preparation, chemical structure, and immunostimulatory activity of a water-soluble heteropolysaccharide from Suillus granulatus fruiting bodies. [Abstract]

2022 Jan 15:13:100211. PMID: 35498979
J Eur Acad Dermatol Venereol

Recombinant Treponema pallidum protein Tp0136 promotes fibroblast migration by modulating MCP-1/CCR2 through TLR4. [Abstract]

2020 Apr;34(4):862-872. PMID: 31856347
Oncogene

The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation. [Abstract]

2025 May;44(16):1078-1092. PMID: 39865175
Oncogene

NRG1 regulates Fra-1 transcription and metastasis of triple-negative breast cancer cells via the c-Myc ubiquitination as manipulated by ERK1/2-mediated Fbxw7 phosphorylation. [Abstract]

2022 Feb;41(6):907-919. PMID: 34992218
Oncogene

CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer. [Abstract]

2017 Apr;36(15):2095-2104. PMID: 27721403
Apoptosis

The GATA3-RFPL3-ASK1 axis suppresses breast cancer growth and lung metastasis. [Abstract]

2026 Apr 17;31(4):127. PMID: 41995771
Apoptosis

Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation. [Abstract]

2021 Apr;26(3-4):195-208. PMID: 33550458
Npg Asia Mater

(2019) 11:38
Leukemia

BCR::ABL1 tyrosine kinase inhibitors induce ribosome collisions to activate ZAK-dependent ribotoxic stress and apoptosis in chronic myeloid leukemia. [Abstract]

2026 May;40(5):955-969. PMID: 41912913
Int J Biol Macromol

Isolation, structural characterization and immunoregulatory activity of a novel acidic polysaccharide from Ganoderma sinense. [Abstract]

2026 Mar 3:151196. PMID: 41786176
Int J Biol Macromol

λ-Carrageenan regulates antiviral responses by targeting classical NF-κB and IRF3-mediated signaling pathways. [Abstract]

2025 Dec 17;338(Pt 2):149760. PMID: 41418949
Int J Biol Macromol

Gintonin exerts effects via LPAR1/3 and the MEK signaling pathway. [Abstract]

2025 Sep:326:147087. PMID: 40865829
Int J Nanomedicine

Novel L-(CaP-ZnP)/SA Nanocomposite Hydrogel with Dual Anti-Inflammatory and Mineralization Effects for Efficient Vital Pulp Therapy. [Abstract]

2024 Jul 3:19:6659-6676. PMID: 38975320
New Phytol

LbSakA-mediated phosphorylation of the scaffolding protein LbNoxR in the ectomycorrhizal basidiomycete Laccaria bicolor regulates NADPH oxidase activity, ROS accumulation and symbiosis development. [Abstract]

2024 Jul;243(1):381-397. PMID: 38741469
Int J Biol Macromol

Fungal antitumor protein D1 is internalized via endocytosis and inhibits non-small cell lung cancer proliferation through MAPK signaling pathway. [Abstract]

2023 Feb 1:227:45-57. PMID: 36521713
Int J Biol Macromol

Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAMs and T lymphocytes. [Abstract]

2020 May 1:150:261-280. PMID: 32044366
Int J Mol Med

Targeting p38 MAPK signaling pathway: Quercetin as a novel therapy for TMJ synovitis. [Abstract]

2026 Jan;57(1):21. PMID: 41235659
NPJ Parkinsons Dis

Disruption of axonal transport in Parkinson's disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling. [Abstract]

2025 May 6;11(1):114. PMID: 40328804
Int J Mol Med

Inflammation and coagulation abnormalities via the activation of the HMGB1‑RAGE/NF‑κB and F2/Rho pathways in lung injury induced by acute hypoxia. [Abstract]

2023 Aug;52(2):67. PMID: 37350396
Neural Regen Res

Macrophage migration inhibitory factor facilitates astrocytic production of the CCL2 chemokine following spinal cord injury. [Abstract]

2023 Aug;18(8):1802-1808. PMID: 36751809
Mol Ther Oncolytics

Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model. [Abstract]

2022 Aug 5:26:372-386. PMID: 36090480
Int J Mol Med

Echinacea polysaccharide attenuates lipopolysaccharide‑induced acute kidney injury via inhibiting inflammation, oxidative stress and the MAPK signaling pathway. [Abstract]

2021 Jan;47(1):243-255. PMID: 33416087
Antioxidants (Basel)

CASK Mediates Oxidative Stress-Induced Microglial Apoptosis-Inducing Factor-Independent Parthanatos Cell Death via Promoting PARP-1 Hyperactivation and Mitochondrial Dysfunction. [Abstract]

2024 Mar 13;13(3):343. PMID: 38539876
Antioxidants (Basel)

Canagliflozin Delays Aging of HUVECs Induced by Palmitic Acid via the ROS/p38/JNK Pathway. [Abstract]

2023 Mar 30;12(4):838. PMID: 37107212
Antioxidants (Basel)

Docosahexaenoic Acid Alleviates Palmitic Acid-Induced Inflammation of Macrophages via TLR22-MAPK-PPARγ/Nrf2 Pathway in Large Yellow Croaker ( Larimichthys crocea). [Abstract]

2022 Mar 31;11(4):682. PMID: 35453367
Antioxidants (Basel)

Characterization of the Inducible and Slow-Releasing Hydrogen Sulfide and Persulfide Donor P*: Insights into Hydrogen Sulfide Signaling. [Abstract]

2021 Jun 29;10(7):1049. PMID: 34209813
Antioxidants (Basel)

Tart Cherry Extract Containing Chlorogenic Acid, Quercetin, and Kaempferol Inhibits the Mitochondrial Apoptotic Cell Death Elicited by Airborne PM10 in Human Epidermal Keratinocytes. [Abstract]

2021 Mar 13;10(3):443. PMID: 33805724
Haematologica

Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production. [Abstract]

2020 Jan;105(1):124-135. PMID: 30948489
Phytother Res

Formosanin C Induces ROS/p38-Mediated Cell Death While Also Promoting Protective Autophagy in Pancreatic Cancer. [Abstract]

2025 Oct 6. PMID: 41054182
Phytother Res

Chinese dragon's blood ethyl acetate extract suppresses gastric cancer progression through induction of apoptosis and autophagy mediated by activation of MAPK and downregulation of the mTOR-Beclin1 signalling cascade. [Abstract]

2023 Feb;37(2):689-701. PMID: 36245270
Chem Sci

Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophage-mediated immunotherapy. [Abstract]

2018 Jan 31;9(10):2674-2689. PMID: 29732051
Free Radic Biol Med

Glucagon-like peptide-1 receptor activation maintains extracellular matrix integrity by inhibiting the activity of mitogen-activated protein kinases and activator protein-1. [Abstract]

2021 Dec;177:247-259. PMID: 34737144
Free Radic Biol Med

p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice. [Abstract]

2019 Nov 1:143:275-287. PMID: 31442556
Free Radic Biol Med

GL-V9 induced upregulation and mitochondrial localization of NAG-1 associates with ROS generation and cell death in hepatocellular carcinoma cells. [Abstract]

2017 Nov:112:49-59. PMID: 28697922

Adezmapimod purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2017 Nov:112:49-59. [Abstract]

Cells are pre-treated with ERK (U1026) and p38 (SB203580) inhibitors, followed by GL-V9 treatment for 24 h. Western blot is performed to analyze NAG-1 expression.
EMBO Mol Med

Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation. [Abstract]

2025 Mar;17(3):535-562. PMID: 39948420
EMBO Mol Med

PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS-driven ELR+ CXC chemokine expression. [Abstract]

2023 Jan 11;15(1):e16373. PMID: 36511116
Am J Chin Med

Nephroprotective Effects of Formononetin in Diabetic Kidney Disease: Mechanistic Insights and Therapeutic Potential. [Abstract]

2025;53(7):2277-2305. PMID: 40947647
Stem Cell Res Ther

The cannabinoid receptor I (CB1) enhanced the osteogenic differentiation of BMSCs by rescue impaired mitochondrial metabolism function under inflammatory condition. [Abstract]

2022 Jan 21;13(1):22. PMID: 35063024
Stem Cell Res Ther

Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis. [Abstract]

2021 May 20;12(1):295. PMID: 34016178
Cell Rep

Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer. [Abstract]

2026 Jun 20;45(7):117583. PMID: 42322608
Curr Res Food Sci

Apigenin and its octoic acid diester attenuated glycidol-induced autophagic-dependent apoptosis via inhibiting the ERK/JNK/p38 signaling pathways in human umbilical vein endothelial cells (HUVECs). [Abstract]

2023 Jan 16:6:100447. PMID: 36699118
Cell Rep

Multi-omics profiling visualizes dynamics of cardiac development and functions. [Abstract]

2022 Dec 27;41(13):111891. PMID: 36577384
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Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis. [Abstract]

2022 Jul;21(7):e13659. PMID: 35712918
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RORγt phosphorylation protects against T cell-mediated inflammation. [Abstract]

2022 Mar 15;38(11):110520. PMID: 35294872
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Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway. [Abstract]

2020 Oct;19(10):e13217. PMID: 32840323
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FBXW7 Confers Radiation Survival by Targeting p53 for Degradation. [Abstract]

2020 Jan 14;30(2):497-509.e4. PMID: 31940492
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FGF9 promotes mouse spermatogonial stem cell proliferation mediated by p38 MAPK signalling. [Abstract]

2021 Jan;54(1):e12933. PMID: 33107118
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CB1 enhanced the osteo/dentinogenic differentiation ability of periodontal ligament stem cells via p38 MAPK and JNK in an inflammatory environment. [Abstract]

2019 Nov;52(6):e12691. PMID: 31599069
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Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin A via the cAMP/PKA/p38 MAPK/CREB signaling pathway. [Abstract]

2024 Jul:119:36-50. PMID: 38555991
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Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway. [Abstract]

2023 Jan;21(1):36-46. PMID: 36641231
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Spinal heat shock protein 27 participates in PDGFRβ-mediated morphine tolerance through PI3K/Akt and p38 MAPK signalling pathways. [Abstract]

2020 Nov;177(22):5046-5062. PMID: 32559815
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Phytoglycoprotein isolated from Dioscorea batatas Decne promotes intestinal epithelial wound healing. [Abstract]

2020 Oct;18(10):738-748. PMID: 33039053
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Zinc finger protein 91 positively regulates the production of IL-1β in macrophages by activation of MAPKs and non-canonical caspase-8 inflammasome. [Abstract]

2018 Dec;175(23):4338-4352. PMID: 30182366

Adezmapimod purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2018 Dec;175(23):4338-4352. [Abstract]

Treatment of macrophages with inhibitor of p38 (SB203580) or JNK (SP600125) inhibits the synthesis of pro-IL-1β in ZFP91-overexpressing THP-1 cells.
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Ferulic acid in combination with ginsenoside Rb1 alleviates myocardial no-reflow by inhibiting platelet HMGB1 release and NET formation. [Abstract]

2026 Jan 8;21(1):16. PMID: 41501834
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Inhibition of P2X7 receptor in satellite glial cells contributes to electroacupuncture's analgesia in rats with CFA-induced inflammatory pain. [Abstract]

2025 Oct 5;20(1):159. PMID: 41046250
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Docosahexaenoic Acid Attenuates Radiation-Induced Myocardial Fibrosis by Inhibiting the p38/ET-1 Pathway in Cardiomyocytes. [Abstract]

2023 Apr 1;115(5):1229-1243. PMID: 36529557
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Corydalis saxicola Bunting total alkaloids attenuate paclitaxel-induced peripheral neuropathy through PKCε/p38 MAPK/TRPV1 signaling pathway. [Abstract]

2021 Jul 19;16(1):58. PMID: 34281577
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Impacts of combined exposure to formaldehyde and PM2.5 at ambient concentrations on airway inflammation in mice. [Abstract]

2022 Dec 15:315:120234. PMID: 36195197
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BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis. [Abstract]

2021 Jan 1;268(Pt B):115748. PMID: 33022573
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Exposure to both formaldehyde and high relative humidity exacerbates allergic asthma by activating the TRPV4-p38 MAPK pathway in Balb/c mice. [Abstract]

2020 Jan:256:113375. PMID: 31662264
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Construction of a lipid metabolism-based prognostic gene signature in cervical squamous cell carcinoma and validation of LIPG's oncogenic role. [Abstract]

2025 Oct 14;25(1):349. PMID: 41088247
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Advanced Glycation End Products Promote Melanogenesis by Activating NLRP3 Inflammasome in Human Dermal Fibroblasts. [Abstract]

2022 Oct;142(10):2591-2602.e8. PMID: 35421403
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LPCAT1 Promotes Cutaneous Squamous Cell Carcinoma via EGFR-Mediated Protein Kinase B/p38MAPK Signaling Pathways. [Abstract]

2022 Feb;142(2):303-313.e9. PMID: 34358528
Front Immunol

Macrophage Polarization Modulated by Porcine Circovirus Type 2 Facilitates Bacterial Coinfection. [Abstract]

2021 Jul 28:12:688294. PMID: 34394082
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Butorphanol Promotes Macrophage Phenotypic Transition to Inhibit Inflammatory Lung Injury via κ Receptors. [Abstract]

2021 Jul 7:12:692286. PMID: 34305926
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HMGB1 Promotes the Release of Sonic Hedgehog From Astrocytes. [Abstract]

2021 Apr 1:12:584097. PMID: 33868221
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miR-146a Inhibits Biofilm-Derived Cutibacterium acnes-Induced Inflammatory Reactions in Human Keratinocytes. [Abstract]

2019 Dec;139(12):2488-2496.e4. PMID: 31194941
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Streptococcus Suis Serotype 2 Stimulates Neutrophil Extracellular Traps Formation via Activation of p38 MAPK and ERK1/2. [Abstract]

2018 Dec 7:9:2854. PMID: 30581435

Adezmapimod purchased from MedChemExpress. Usage Cited in: Front Immunol. 2018 Dec 7:9:2854. [Abstract]

Neutrophils are pretreated with inhibitor of p38 MAPK (SB203580 (Adezmapimod)) and ERK1/2 (U0126), and the cells are then incubated with either SS2 ZY05719 or PMA for 3 h. Immunofluorescence is performed.
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Stimulator of Interferon Genes Promotes Host Resistance Against Pseudomonas aeruginosa Keratitis. [Abstract]

2018 Jun 5:9:1225. PMID: 29922287
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Characterization of Rabbit Nucleotide-Binding Oligomerization Domain 1 (NOD1) and the Role of NOD1 Signaling Pathway during Bacterial Infection. [Abstract]

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Metabolic benefits of inhibition of p38α in white adipose tissue in obesity. [Abstract]

2018 May 11;16(5):e2004225. PMID: 29750781

Adezmapimod purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2018 May 11;16(5):e2004225. [Abstract]

Representative western blots of p-CREB (Ser133) and UCP-1 in iWAT from C57BL/6J mice after 4 wk of SB203580 treatment. These mice are exposed to cold for 2 d before analysis.
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Elephantopus scaber suppresses ConA-induced T cell activation by inhibiting NF-κB and Ca2+/NFAT signaling. [Abstract]

2026 May 10:362:121364. PMID: 41687940
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Cedrol from Platycladus orientalis (L.) Franco regulates M1/M2 polarization of macrophages and promotes hair regeneration. [Abstract]

2026 Apr 24:361:121268. PMID: 41611183
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ANGPTL8 links refeeding to monocyte dynamics and metabolic inflammation via the CCL5-CCR5 axis. [Abstract]

2025 Nov 25:e196605. PMID: 41289013
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Elephantopus scaber attenuates MC903-caused atopic dermatitis and decreases TNF-α/IFN-γ-induced chemokines by suppressing MKP-1-mediated AP-1 signaling in keratinocytes. [Abstract]

2025 Aug 29:352:120267. PMID: 40633861
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Shenling Baizhu Powder and Betulin attenuate sepsis-induced intestinal injury by targeting GADD45B/TAOK1/p38 MAPK pathway. [Abstract]

2025 Jul 11;353(Pt A):120282. PMID: 40653040
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Artemisia argyi volatile oil ameliorates allergic contact dermatitis via modulating TRPA1/CGRP signaling. [Abstract]

2024 Nov 15:334:118580. PMID: 39019419
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Study on the anti-skin aging effect and mechanism of Sijunzi Tang based on network pharmacology and experimental validation. [Abstract]

2024 Oct 28:333:118421. PMID: 38880400
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Baicalin suppresses macrophage JNK-mediated adipose tissue inflammation to mitigate insulin resistance in obesity. [Abstract]

2024 Oct 5:332:118355. PMID: 38762213
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Multi-technology integrated network pharmacology-based study on phytochemicals, active metabolites, and molecular mechanism of Psoraleae Fructus to promote melanogenesis. [Abstract]

2024 May 10:325:117755. PMID: 38218502
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Drug-containing serum of rhubarb-astragalus capsule inhibits the epithelial-mesenchymal transformation of HK-2 by downregulating TGF-β1/p38MAPK/Smad2/3 pathway. [Abstract]

2021 Nov 15:280:114414. PMID: 34314804
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Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2. [Abstract]

2024 Nov 20;72(46):25601-25619. PMID: 39508235
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Dendrobine Ameliorates Glucocorticoid-Induced Osteoporosis by Promoting Osteogenesis through JNK/p38 MAPK Pathway Activation and GR Nuclear Translocation Inhibition. [Abstract]

2024 Jul 31;72(30):16739-16748. PMID: 39033544
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Molecular Mechanism Study of Dietary Fiber Lignin Intervention in Ulcerative Colitis through GPR37. [Abstract]

2024 Jun 7. PMID: 38845410
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Chlorogenic Acid Alleviates Chronic Stress-Induced Intestinal Damage by Inhibiting the P38MAPK/NF-κB Pathway. [Abstract]

2023 Jun 21;71(24):9381-9390. PMID: 37293923
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Synergistic Combination of the Total Steroidal Saponins from the Berries of Black Nightshade and Adriamycin to Overcome Leukemia Multidrug Resistance. [Abstract]

2023 Feb 8. PMID: 36752041
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Isolation, Identification, and Immunomodulatory Mechanism of Peptides from Lepidium meyenii (Maca) Protein Hydrolysate. [Abstract]

2022 Apr 13;70(14):4328-4341. PMID: 35357828
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Attenuation of tert-Butyl Hydroperoxide ( t-BHP)-Induced Oxidative Damage in HepG2 Cells by Tangeretin: Relevance of the Nrf2-ARE and MAPK Signaling Pathways. [Abstract]

2018 Jun 27;66(25):6317-6325. PMID: 29871486

Adezmapimod purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2018 Jun 27;66(25):6317-6325. [Abstract]

HepG2 cells are pre-incubated with 20 µM SB203580, SP600125 and PD98059 for 1 h and then treated with tangeretin(20µM) for 24 h.
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Integrating network toxicology, transcriptomics, and metabolomics uncovers the hepatotoxic mechanisms of okadaic acid in LO2 cells. [Abstract]

2025 Sep 1:302:118576. PMID: 40561608
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JNK molecule is a toxic target for IPEC-J2 cell barrier damage induced by T-2 toxin. [Abstract]

2023 Sep 15:263:115247. PMID: 37453270
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Disruption of the GABAergic system contributes to the development of perioperative neurocognitive disorders after anesthesia and surgery in aged mice. [Abstract]

2020 Sep;26(9):913-924. PMID: 32488976
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Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway. [Abstract]

2020 Mar 1:190:110133. PMID: 31896473
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UFM1 suppresses VSMCs phenotypic switching and attenuates atherosclerosis by inhibiting AKT phosphorylation. [Abstract]

2026 Aug;250(Pt 1):117957. PMID: 41974329
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IL-18 potentiates platelet activation and thrombosis through IL-18Rα-dependent MAPKs and PI3K/Akt signaling. [Abstract]

2026 Mar:245:117656. PMID: 41421453
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Molecular Dissection of the AHR-AREG driven EGFR-ERK1/2-CyclinD1 axis in acquired lenvatinib resistance of Hepatocellular carcinoma. [Abstract]

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Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells. [Abstract]

2024 May:223:116194. PMID: 38583812
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TP53R175H mutation promotes breast cancer cell proliferation through CORO1A-P38 MAPK pathway regulation. [Abstract]

2024 Mar:221:116047. PMID: 38331350
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Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7. [Abstract]

2023 Jun 21;80(7):186. PMID: 37344704
Cell Mol Life Sci

HBeAg induces the expression of macrophage miR-155 to accelerate liver injury via promoting production of inflammatory cytokines. [Abstract]

2018 Jul;75(14):2627-2641. PMID: 29349567
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Targeted inhibition of JMJD2C/MALAT1 axis compensates for the deficiency of metformin in reversing ovarian cancer platinum resistance. [Abstract]

2025 Jul 15:373:123663. PMID: 40280301
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A novel exosome-like nanovesicles from Cordyceps militaris potentiate immunomodulatory and anti-tumor effect by reprogramming macrophages. [Abstract]

2024 Dec 1:358:123163. PMID: 39442867
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AMPK activation reduces cancer cell aggressiveness via inhibition of monoamine oxidase A (MAO-A) expression/activity. [Abstract]

2024 Sep 1:352:122857. PMID: 38914305
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Inhibition of EZH2 ameliorates hyperoxaluria-induced kidney injury through the JNK/FoxO3a pathway. [Abstract]

2022 Feb 15:291:120258. PMID: 34952043
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Peptide DR8 suppresses epithelial-to-mesenchymal transition via the TGF-β/MAPK signaling pathway in renal fibrosis. [Abstract]

2020 Nov 15:261:118465. PMID: 32956665
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Anterior gradient 2-derived peptide upregulates major histocompatibility complex class I-related chains A/B in hepatocellular carcinoma cells. [Abstract]

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Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. [Abstract]

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DNA damage promotes microtubule dynamics through a DNA-PK-AKT axis for enhanced repair. [Abstract]

2021 Feb 1;220(2):e201911025. PMID: 33404607
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Cannabinoids Reduce Extracellular Vesicle Release from HIV-1 Infected Myeloid Cells and Inhibit Viral Transcription. [Abstract]

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β-Elemene Attenuates Fibrosis after Esophageal Endoscopic Submucosal Dissection via Modulating the HIF-1α/HK2/p38-MAPK Signaling Axis. [Abstract]

2021 Jul 12;7(7):3399-3408. PMID: 34109793
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Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection. [Abstract]

2021 Jul 5;22(7):e51678. PMID: 33987949
Nat Prod Bioprospect

Deacetylforskolin ameliorates bleomycin-induced pulmonary fibrosis by suppressing inflammation and TGF-β1-induced epithelial-mesenchymal transition. [Abstract]

2026 Apr 13;16(1):52. PMID: 41968199
Cancer Immunol Immunother

CCL8-dependent recruitment of natural killer cells enhances the antitumor activity of neoadjuvant chemotherapy in gastric cancer. [Abstract]

2026 Mar 17;75(4):112. PMID: 41843172
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P38α MAPK-induced senescence in cranial suture progenitor cells promotes craniosynostosis. [Abstract]

2025 Dec 13. PMID: 41390905
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Epigenetic modulation of odontoblast differentiation: implications for regenerative endodontics. [Abstract]

2025 Oct:161:105978. PMID: 40669605
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Retinol binding protein 4 restricts PCV2 replication via selective autophagy degradation of viral ORF1 protein. [Abstract]

2024 Nov 5;7(1):1438. PMID: 39500783
Commun Biol

Suppressing MTERF3 inhibits proliferation of human hepatocellular carcinoma via ROS-mediated p38 MAPK activation. [Abstract]

2024 Jan 5;7(1):18. PMID: 38177713
Commun Biol

mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling. [Abstract]

2022 Jul 22;5(1):726. PMID: 35869262
Eur J Pharmacol

Cilostazol and SB203580 combination: Targeting ER stress and p38MAPK signaling in Alzheimer's disease mouse model. [Abstract]

2025 Sep 15:1003:177897. PMID: 40609614
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IRAK-M has effects in regulation of lung epithelial inflammation. [Abstract]

2023 Apr 7;24(1):103. PMID: 37029363
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Cyclosporin A up-regulated thromboxane A2 receptor through activation of MAPK and NF-κB pathways in rat mesenteric artery. [Abstract]

2022 Jul 5:926:175034. PMID: 35588871
Respir Res

Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling pathways in hypoxic pulmonary hypertension. [Abstract]

2022 Jan 11;23(1):6. PMID: 35016680
Eur J Pharmacol

Xanthine oxidoreductase promotes the progression of colitis-associated colorectal cancer by causing DNA damage and mediating macrophage M1 polarization. [Abstract]

2021 Sep 5:906:174270. PMID: 34171392
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IL-1β augments TGF-β inducing epithelial-mesenchymal transition of epithelial cells and associates with poor pulmonary function improvement in neutrophilic asthmatics. [Abstract]

2021 Aug 3;22(1):216. PMID: 34344357
Eur J Pharmacol

Carvacrol alleviates liver fibrosis by inhibiting TRPM7 and modulating the MAPK signaling pathway. [Abstract]

2021 May 5:898:173982. PMID: 33647257
Front Endocrinol

Toll-Like Receptor 4 Inhibits Estradiol Secretion via NF-κB Signaling in Human Granulosa Cells. [Abstract]

2021 Mar 12:12:629554. PMID: 33776924
Acta Physiol (Oxf)

MICAL2 promotes breast cancer cell migration by maintaining epidermal growth factor receptor (EGFR) stability and EGFR/P38 signalling activation. [Abstract]

2018 Feb;222(2). PMID: 28719045

Adezmapimod purchased from MedChemExpress. Usage Cited in: Acta Physiol (Oxf). 2018 Feb;222(2). [Abstract]

P38 inhibitor SB203580 (Adezmapimod) pretreatment also decreases p-HSP27 and MMP9 levels induced by MICAL2-overexpression.
Int J Mol Sci

Aspirin Eugenol Ester Ameliorates Fatty Liver Hemorrhagic Syndrome in Laying Hens by Reducing Oxidative Stress and Inflammation. [Abstract]

2026 Jan;27(11):4811. PMID: 42278341
Int Immunopharmacol

Eicosapentaenoic acid attenuates hyperoxia-induced lung injury via p38 MAPK/NF-κB-mediated regulation of glycolytic reprogramming. [Abstract]

2026 Jan 1;168(Pt 2):115903. PMID: 41270643
Int Immunopharmacol

MIF regulates T helper 17 cell differentiation by activating the p38 MAPK signaling pathway to drive the pathogenesis of EAP. [Abstract]

2025 Jun 26:159:114959. PMID: 40440956
Int Immunopharmacol

Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway. [Abstract]

2025 May 16:155:114550. PMID: 40215776
Int Immunopharmacol

LXA4 alleviates inflammation and ferroptosis in cigarette smoke induced chronic obstructive pulmonary disease via the ALX/FPR2 receptor. [Abstract]

2025 Apr 4:151:114322. PMID: 40007378
Int Immunopharmacol

House dust mite induced mucosal barrier dysfunction and type 2 inflammatory responses via the MAPK/AP-1/IL-24 Signaling pathway in allergic rhinitis. [Abstract]

2025 Feb 20:148:113972. PMID: 39826453
Int J Mol Sci

Neutrophil Extracellular Trap Formation Model Induced by Monosodium Urate and Phorbol Myristate Acetate: Involvement in MAPK Signaling Pathways. [Abstract]

2024 Dec 27;26(1):143. PMID: 39796001
Int Immunopharmacol

The ellagitannin metabolite urolithin C attenuated cognitive impairment by inhibiting neuroinflammation via downregulation of MAPK/NF-kB signaling pathways in aging mice. [Abstract]

2024 Sep 19;142(Pt B):113151. PMID: 39303538
Int Immunopharmacol

Escin alleviates cerebral ischemia-induced intestinal pyroptosis via the GR-dependent p38 MAPK/NF-κB signaling and NLRP3 inflammasome activation. [Abstract]

2024 Sep 10:138:112592. PMID: 38955024
Int Immunopharmacol

Carnosol attenuates angiotensin II-induced cardiac remodeling and inflammation via directly binding to p38 and inhibiting p38 activation. [Abstract]

2024 Jun 15:134:112143. PMID: 38692016
Int Immunopharmacol

The protective effect of Ergolide in osteoarthritis: In vitro and in vivo studies. [Abstract]

2024 Jan 25:127:111355. PMID: 38157693
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Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG Cells. [Abstract]

2023 Jul 6;24(13):11168. PMID: 37446360
Int Immunopharmacol

Parthenolide alleviates microglia-mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder. [Abstract]

2023 Jul:120:110287. PMID: 37182449
Int J Mol Sci

Cigarette Smoke Extract Induces p38 MAPK-Initiated, Fas-Mediated Eryptosis. [Abstract]

2022 Nov 25;23(23):14730. PMID: 36499060
Int J Mol Sci

Silencing P2X7R Alleviates Diabetic Neuropathic Pain Involving TRPV1 via PKCε/P38MAPK/NF-κB Signaling Pathway in Rats. [Abstract]

2022 Nov 16;23(22):14141. PMID: 36430617
Int J Mol Sci

Androgen-Responsive Oncogenic lncRNA RP11-1023L17.1 Enhances c-Myc Protein Stability in Prostate Cancer. [Abstract]

2022 Oct 13;23(20):12219. PMID: 36293081
Int Immunopharmacol

Bone marrow mesenchymal stem cells modified with heme oxygenase-1 alleviate rejection of donation after circulatory death liver transplantation by inhibiting dendritic cell maturation in rats. [Abstract]

2022 Jun:107:108643. PMID: 35240383
Int J Mol Sci

Suppression of Cutibacterium acnes-Mediated Inflammatory Reactions by Fibroblast Growth Factor 21 in Skin. [Abstract]

2022 Mar 25;23(7):3589. PMID: 35408949
Int Immunopharmacol

Topoisomerase 2 inhibitor etoposide promotes interleukin-10 production in LPS-induced macrophages via upregulating transcription factor Maf and activating PI3K/Akt pathway. [Abstract]

2021 Dec;101(Pt A):108264. PMID: 34715493
Int Immunopharmacol

Dihydroartemisinin prevents dextran sodium sulphate-induced colitisthrough inhibition of the activation of NLRP3 inflammasome and p38 MAPK signaling. [Abstract]

2020 Nov:88:106949. PMID: 32892075
Int Immunopharmacol

Chebulanin exerts its anti-inflammatory and anti-arthritic effects via inhibiting NF-κB and MAPK activation in collagen-induced arthritis mice. [Abstract]

2020 Nov:88:106823. PMID: 32795901
Int Immunopharmacol

FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway. [Abstract]

2020 Jun:83:106473. PMID: 32272397
Artif Cells Nanomed Biotechnol

Plastin 3 down-regulation augments the sensitivity of MDA-MB-231 cells to paclitaxel via the p38 MAPK signalling pathway. [Abstract]

2019 Dec;47(1):685-695. PMID: 30829071
Int Immunopharmacol

Macrophages-derived p38α promotes the experimental severe acute pancreatitis by regulating inflammation and autophagy. [Abstract]

2019 Dec:77:105940. PMID: 31655340
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The efficacy and potential mechanism of cnidium lactone to inhibit osteoclast differentiation. [Abstract]

2019 Dec;47(1):3087-3093. PMID: 31343277
Int Immunopharmacol

The immunomodulatory effect of Poria cocos polysaccharides is mediated by the Ca2+/PKC/p38/NF-κB signaling pathway in macrophages. [Abstract]

2019 Jul:72:252-257. PMID: 31003002
Neurochem Int

DUSP1-mediated suppression of p38 MAPK signaling pathway reduces ferroptosis in cerebral ischemia-reperfusion injury. [Abstract]

2025 Oct:189:106024. PMID: 40752646
Neurochem Int

Spinal p38 MAPK/PGC-1α/SIRT3 signaling pathway mediates remifentanil-induced hyperalgesia in rats via ROS release and NR2B activation. [Abstract]

2025 Sep 26:106061. PMID: 41016638
Mol Neurobiol

GDF11 Regulates M1 and M2 Polarization of BV2 Microglial Cells via p38 MAPK Signaling Pathway. [Abstract]

2025 Jul;62(7):9290-9305. PMID: 40100492
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Vascular endothelial growth factor promotes transdifferentiation of astrocytes into neurons via activation of the MAPK/Erk-Pax6 signal pathway. [Abstract]

2023 Jul;71(7):1648-1666. PMID: 36960578
Neurochem Int

Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson's disease via inhibiting p38MAPK/NF-κB signaling pathway. [Abstract]

2022 Jan:152:105221. PMID: 34780806
Invest Ophthalmol Vis Sci

Indoleamine 2,3-Dioxygenase Regulates Macrophage Recruitment, Polarization and Phagocytosis in Aspergillus Fumigatus Keratitis. [Abstract]

2020 Jul 1;61(8):28. PMID: 32692841
Front Cell Infect Microbiol

Fosfomycin Protects Mice From Staphylococcus aureus Pneumonia Caused by α-Hemolysin in Extracellular Vesicles by Inhibiting MAPK-Regulated NLRP3 Inflammasomes. [Abstract]

2019 Jul 15:9:253. PMID: 31380296
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Impaired BCAA Catabolism Contributes To Acute Lung Injury By Triggering Oxidative Stress and Inflammatory Response Via the MAPK Pathway. [Abstract]

2026 Feb 4;49(1):83. PMID: 41636928
Front Pharmacol

The volatile oil of Acorus tatarinowii schott significantly attenuates neuroinflammatory damage in a rat model of tourette syndrome by inhibiting the p38 MAPK/NLRP3/STAT3 signaling pathway. [Abstract]

2025 Sep 25:16:1540092. PMID: 41079740
Arthritis Res Ther

Roles of VWA1 and Rac2 in compensatory and decompensatory responses via FGF9/FGFR3 and p38 MAPK signaling pathways in condylar chondrocytes under distinct mechanical stress. [Abstract]

2025 May 31;27(1):118. PMID: 40450276
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Role for IRAK-4 and p38 in Neutrophil Signaling in Response to Bacterial Lipoproteins from Staphylococcus aureus. [Abstract]

2024 Sep 20. PMID: 39302496
Am J Physiol Cell Physiol

ATP promotes resident CD34+ cell migration mainly through P2Y2-Stim1-ERK/p38 pathway. [Abstract]

2023 Nov 1;325(5):C1228-C1243. PMID: 37721000
Am J Physiol Cell Physiol

DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition. [Abstract]

2022 Jul 1;323(1):C133-C144. PMID: 35584329
J Periodontal Res

Activation of GATA-binding protein 4 regulates monocyte chemoattractant protein-1 and chemotaxis in periodontal ligament cells. [Abstract]

2022 Jan;57(1):195-204. PMID: 34773653
Front Pharmacol

Tanshinone I Inhibits Oxidative Stress-Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling. [Abstract]

2021 May 18;12:644116. PMID: 34084132
Front Pharmacol

Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization. [Abstract]

2021 Apr 30:12:644886. PMID: 33995055
J Clin Endocrinol Metab

Catecholestradiol Activation of Adrenergic Receptors Induces Endometrial Cell Survival via p38 MAPK Signaling. [Abstract]

2021 Jan 23;106(2):337-350. PMID: 33247592
Am J Physiol Cell Physiol

Reversal of cisplatin resistance by microRNA-139-5p-independent RNF2 downregulation and MAPK inhibition in ovarian cancer. [Abstract]

2018 Aug 1;315(2):C225-C235. PMID: 29719173

Adezmapimod purchased from MedChemExpress. Usage Cited in: Am J Physiol Cell Physiol. 2018 Aug 1;315(2):C225-C235. [Abstract]

Western blot analysis shows that inhibiting MAPK cannot completely reverse increased expression of RNF2 and CDDP resistance of OC cells.
Front Cell Dev Biol

Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway. [Abstract]

2021 Nov 5:9:741060. PMID: 34805150
Front Cell Dev Biol

Potential Mechanisms of the Impact of Hepatocyte Growth Factor Gene-Modified Tendon Stem Cells on Tendon Healing. [Abstract]

2021 Jun 18;9:659389. PMID: 34222233
Front Cell Dev Biol

MiR-132-3p Modulates MEKK3-Dependent NF-κB and p38/JNK Signaling Pathways to Alleviate Spinal Cord Ischemia-Reperfusion Injury by Hindering M1 Polarization of Macrophages. [Abstract]

2021 Feb 11:9:570451. PMID: 33644040
Eye Vis (Lond)

STING deficiency alleviates scar formation after glaucoma filtration surgery by suppressing p38 MAPK-induced inflammation in mice. [Abstract]

2026 Feb 2;13(1):7. PMID: 41622229
Chem Biol Interact

Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells. [Abstract]

2021 Oct 1:348:109634. PMID: 34506768
Toxicology

Aspirin eugenol ester ameliorates paraquat-induced oxidative damage through ROS/p38-MAPK-mediated mitochondrial apoptosis pathway. [Abstract]

2021 Apr 15:453:152721. PMID: 33592258
AAPS PharmSciTech

One-Way Intestinal Perfusion of PVP/VA-Poloxamer 188-Curcuma longa L. Extract Solid Dispersion in Rats In Vivo and Its Effect on HSC-T6 Cell Proliferation. [Abstract]

2022 Mar 14;23(3):83. PMID: 35288813
Molecules

Plant-Derived Molecule 4-Methylumbelliferone Suppresses FcεRI-Mediated Mast Cell Activation and Allergic Inflammation. [Abstract]

2022 Feb 27;27(5):1577. PMID: 35268679
Food Sci Nutr

EGCG Alleviates H2O2-Induced Inflammatory Injury and Apoptosis in Bovine Mammary Epithelial Cells Through Nrf2 Pathway Activation and p38MAPK Pathway Inhibition. [Abstract]

2025 Feb 25;13(3):e4687. PMID: 40008238
Mol Med Rep

Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease models via induction of Nrf2. [Abstract]

2022 Jun;25(6):215. PMID: 35543148
Biochim Biophys Acta Mol Basis Dis

Myeloid differential protein-2 inhibition improves diabetic cardiomyopathy via p38MAPK inhibition and AMPK pathway activation. [Abstract]

2022 May 1;1868(5):166369. PMID: 35176461
Mol Med Rep

Metformin inhibits cholesterol‑induced adhesion molecule expression via activating the AMPK signaling pathway in vascular smooth muscle cells. [Abstract]

2021 Oct;24(4):709. PMID: 34396446
Mol Med Rep

Juglone potentiates BRAF inhibitor‑induced apoptosis in melanoma through reactive oxygen species and the p38‑p53 pathway. [Abstract]

2020 Jul;22(1):566-574. PMID: 32377702
Mol Med Rep

Quinalizarin induces ROS‑mediated apoptosis via the MAPK, STAT3 and NF‑κB signaling pathways in human breast cancer cells. [Abstract]

2019 Nov;20(5):4576-4586. PMID: 31702038
Sci Rep

Emetine dihydrochloride suppresses the invasiveness and motility of hepatocellular carcinoma cells through MAPK pathway inhibition and Twist1 protein destabilization. [Abstract]

2026 Jun 23. PMID: 42337289
Sci Rep

Leptin-induced autophagy regulates the immunomodulatory potential of adipose-derived mesenchymal stem cells through down regulating the expression of TSG-6. [Abstract]

2026 Jun 15. PMID: 42298025
Sci Rep

Key donor corneal factors governing successful expansion of human corneal endothelial cells. [Abstract]

2026 May 11. PMID: 42115358
Sci Rep

The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms. [Abstract]

2026 Apr 24;16(1):18943. PMID: 42032081
Sci Rep

Enhancement of melanoma aggressiveness via p38-MAPK, HIF-1α pathways, and metabolic reprogramming induced by Candida albicans. [Abstract]

2025 Nov 17;15(1):40227. PMID: 41249785
PLoS Pathog

Retinol binding protein 4 enhances cellular cholesterol uptake to facilitate influenza A virus infection. [Abstract]

2025 Oct 27;21(10):e1013623. PMID: 41144502
Sci Rep

Deubiquitinating enzyme USP42 promotes breast cancer progression by inhibiting JNK/p38-mediated apoptosis. [Abstract]

2025 Oct 21;15(1):36751. PMID: 41120683
PLoS Pathog

Skin as outermost immune organ of vertebrates that elicits robust early immune responses after immunization with glycoprotein of spring viraemia of carp virus. [Abstract]

2024 Dec 9;20(12):e1012744. PMID: 39652527
Toxics

Polyethylene Terephthalate Microplastic Exposure Induced Reproductive Toxicity Through Oxidative Stress and p38 Signaling Pathway Activation in Male Mice. [Abstract]

2024 Oct 25;12(11):779. PMID: 39590959
Food Sci Anim Resour

Effect of Chicken Age on Proliferation and Differentiation Abilities of Muscle Stem Cells and Nutritional Characteristics of Cultured Meat Tissue. [Abstract]

2024 Sep;44(5):1167-1180. PMID: 39246538
J Lipid Res

Natriuretic peptide receptor-C perturbs mitochondrial respiration in white adipose tissue. [Abstract]

2024 Sep;65(9):100623. PMID: 39154732
Food Sci Anim Resour

Optimal Pre-Plating Method of Chicken Satellite Cells for Cultured Meat Production. [Abstract]

2022 Nov;42(6):942-952. PMID: 36415580
Stem Cell Rev Rep

Dual-specificity Tyrosine Phosphorylation-regulated Kinase Inhibitor ID-8 Promotes Human Somatic Cell Reprogramming by Activating PDK4 Expression. [Abstract]

2022 Aug;18(6):2074-2087. PMID: 35080746
Toxics

Ginsenoside Rg1 Mitigates Porcine Intestinal Tight Junction Disruptions Induced by LPS through the p38 MAPK/ NLRP3 Inflammasome Pathway. [Abstract]

2022 May 27;10(6):285. PMID: 35736894
Sci Rep

PD-L1 mediates lung fibroblast to myofibroblast transition through Smad3 and β-catenin signaling pathways. [Abstract]

2022 Feb 23;12(1):3053. PMID: 35197539
Mediators Inflamm

Expression Profiling of Long Noncoding RNA and Messenger RNA in a Cecal Ligation and Puncture-Induced Colon Injury Mouse Model. [Abstract]

2020 Nov 3:2020:8925973. PMID: 33204219
Int J Cancer

Pharmacological inhibition of the Notch pathway enhances the efficacy of androgen deprivation therapy for prostate cancer. [Abstract]

2018 Aug 1;143(3):645-656. PMID: 29488214
Sci Rep

Vector-independent transmembrane transport of oligodeoxyribonucleotides involves p38 mitogen activated protein kinase phosphorylation. [Abstract]

2017 Oct 19;7(1):13571. PMID: 29051621
J Mol Cell Cardiol

A critical role of cardiac fibroblast-derived exosomes in activating renin angiotensin system in cardiomyocytes. [Abstract]

2015 Dec;89(Pt B):268-79. PMID: 26497614

Adezmapimod purchased from MedChemExpress. Usage Cited in: J Mol Cell Cardiol. 2015 Dec;89(Pt B):268-79. [Abstract]

Dose response of MAPK and Akt inhibitors on cardiac fibroblast-derived exosomes (Exo)-induced activation of MAPKs and Akt. Neonatal rat cardiomyocytes are treated with or without Exo (50 μg/mL), U0126, SP600125, MK-2206, and SB023580 for 20 min and subjected to Western blot analysis. The results are from 4 separate experiments.
Stem Cells

β-Arrestin 2 and Epac2 Cooperatively Mediate DRD1-Stimulated Proliferation of Human Neural Stem Cells and Growth of Human Cerebral Organoids. [Abstract]

2022 Sep 26;40(9):857-869. PMID: 35772103
Stem Cells

DAPK1 Interacts with the p38 Isoform MAPK14, Preventing Its Nuclear Translocation and Stimulation of Bone Marrow Adipogenesis. [Abstract]

2022 May 27;40(5):508-522. PMID: 35403694
Stem Cells

SPARC promotes self-renewal of limbal epithelial stem cells and ocular surface restoration through JNK and p38-MAPK signaling pathways. [Abstract]

2020 Jan;38(1):134-145. PMID: 31644832
Cell Signal

Ubiquitin-editing enzyme A20 protects the inflammatory injury of human corneal epithelial cells against lipoteichoic acid. [Abstract]

2025 Oct:134:111962. PMID: 40578588
Cell Signal

ROCK1 drives colorectal cancer liver metastasis via PRKCH-mediated bioenergetic reprogramming. [Abstract]

2025 Oct 18:112174. PMID: 41115563
Neuropharmacology

ACVR1 drives neuropathic pain by regulating NLRP3-Induced neuronal pyroptosis through the p38 and Smad1/5/8 pathways. [Abstract]

2025 Aug 15:274:110469. PMID: 40250754
J Dairy Sci

Immunomodulatory effects, digestive stability, and action mechanism of casein peptide SPAQILQW in activating macrophages via N-terminal serine. [Abstract]

2025 Apr 28:S0022-0302(25)00284-X. PMID: 40306417
Mol Cell Biochem

Activated TREM1-mediated MAPK signaling in endothelial cells caused by highly expressed STAT1 is associated with intracranial aneurysms occurrence and rupture. [Abstract]

2025 May;480(5):3133-3145. PMID: 39661286
J Dairy Sci

Immunomodulatory activity and molecular mechanisms of action of peptides derived from casein hydrolysate by alcalase and flavourzyme based on virtual screening. [Abstract]

2025 Mar;108(3):2152-2168. PMID: 39603497
Cell Signal

Hyperlipidemia exacerbates acute pancreatitis via interactions between P38MAPK and oxidative stress. [Abstract]

2025 Jan:125:111504. PMID: 39505288
Curr Res Toxicol

Hydrogen sulfide donor NaHS inhibits formaldehyde-induced epithelial-mesenchymal transition in human lung epithelial cells via activating TGF-β1/Smad2/3 and MAPKs signaling pathways. [Abstract]

2024 Oct 24:7:100199. PMID: 39524036
Mol Cell Biochem

MiR-150-5p regulates the functions of type 2 innate lymphoid cells via the ICAM-1/p38 MAPK axis in allergic rhinitis. [Abstract]

2022 Apr;477(4):1009-1022. PMID: 34988856
Cell Signal

YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways. [Abstract]

2021 Sep:85:110060. PMID: 34089814
J Dairy Sci

Sodium butyrate promotes lipopolysaccharide-induced innate immune responses by enhancing mitogen-activated protein kinase activation and histone acetylation in bovine mammary epithelial cells. [Abstract]

2020 Dec;103(12):11636-11652. PMID: 33010913
J Cell Mol Med

Negative feedback loop of ERK/CREB/miR-212-3p inhibits HBeAg-induced macrophage activation. [Abstract]

2020 Sep;24(18):10935-10945. PMID: 32767729
J Cell Mol Med

MD1 deletion exaggerates cardiomyocyte autophagy induced by heart failure with preserved ejection fraction through ROS/MAPK signalling pathway. [Abstract]

2020 Aug;24(16):9300-9312. PMID: 32648659
Cell Signal

TRIM59 expression is regulated by Sp1 and Nrf1 in LPS-activated macrophages through JNK signaling pathway. [Abstract]

2020 Mar:67:109522. PMID: 31883458
J Cell Mol Med

Ligustilide attenuates nitric oxide-induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways. [Abstract]

2019 May;23(5):3357-3368. PMID: 30770640
Cell Signal

The status of MAPK cascades contributes to the induction and activation of Gata4 and Nkx2.5 during the stepwise process of cardiac differentiation. [Abstract]

2019 Feb:54:17-26. PMID: 30471465
J Cell Mol Med

Plectin protects podocytes from adriamycin-induced apoptosis and F-actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway. [Abstract]

2018 Nov;22(11):5450-5467. PMID: 30187999

Adezmapimod purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2018 Nov;22(11):5450-5467. [Abstract]

Treatment with SB203580 (Adezmapimod) significantly abolishes siPlectin-stimulated p38 activation.
Cell Signal

Cell confluence induces switching from proliferation to migratory signaling by site-selective phosphorylation of PDGF receptors on lipid raft platforms. [Abstract]

2016 Feb;28(2):81-93. PMID: 26631574
J Inflamm Res

Dual Effects of Sodium Houttuyfonate Against Acute Rhinosinusitis: Antibacterial Action and Epithelial Barrier Repair Through the p38 MAPK/ERK Pathway. [Abstract]

2025 Sep 29:18:13433-13452. PMID: 41049072
J Inflamm Res

CTRP9 Enhances Efferocytosis in Macrophages via MAPK/Drp1-Mediated Mitochondrial Fission and AdipoR1-Induced Immunometabolism. [Abstract]

2021 Mar 23:14:1007-1017. PMID: 33790616
Aquat Toxicol

Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels. [Abstract]

2018 Jun:199:116-126. PMID: 29621671
Poult Sci

Gut microbiota-derived taurolithocholic acid modulates myofiber-type switching via p38 MAPK/PGC-1α signaling underlying breed differences between Arbor Acres and Taoyuan chickens. [Abstract]

2026 Apr 9;105(7):106914. PMID: 42019469
iScience

Targeting USP14 enhances immunotherapy response by reprogramming tumor-associated macrophages in colon cancer. [Abstract]

2026 Mar 13;29(5):115362. PMID: 42058892
iScience

TLR9 decreases FOXO3 expression to prevent excessive inflammation in macrophage activation syndrome. [Abstract]

2025 Nov 17;28(12):114098. PMID: 41438053
Poult Sci

Comparative analyses of dynamic transcriptome profiles reveal that DUSP1 regulates myogenic differentiation and muscle fiber type transformation. [Abstract]

2025 Oct 3;104(12):105940. PMID: 41077031
iScience

Chemerin 15 enhances microglial phagocytosis to attenuate cerebral ischemia-reperfusion injury through the ChemR23/p38 MAPK pathway. [Abstract]

2025 Aug 19;28(9):113396. PMID: 40970195
iScience

Epigenomic landscapes define differential Janus kinases inhibitor sensitivity in IFN-γ-primed human macrophages. [Abstract]

2025 Apr 22;28(5):112502. PMID: 40491958
Acta Biochim Biophys Sin (Shanghai)

FGF8 promotes lipid droplet accumulation via the FGFR1/p-p38 axis in chondrocytes. [Abstract]

2025 May 15. PMID: 40370197
iScience

The HDL-transporting scavenger receptor B1 promotes viral infection through endolysosomal acidification. [Abstract]

2025 Apr 24;28(6):112501. PMID: 40475258
Neurochem Res

The P38MAPK Pathway Mediates the Destruction of the Blood-Brain Barrier in Anti-NMDAR Encephalitis Mice. [Abstract]

2024 Nov 19;50(1):21. PMID: 39560818
Poult Sci

MAPK signaling pathway participates in the regulation of intestinal phosphorus and calcium absorption in broiler chickens via 1,25-dihydroxyvitamin D3. [Abstract]

2024 Oct;103(10):104052. PMID: 39067128
iScience

AIBP protects drug-induced liver injury by inhibiting MAPK-mediated NR4A1 expression. [Abstract]

2024 Sep 12;27(10):110873. PMID: 39398235
J Periodontol

Connective tissue growth factor promotes cell-to-cell communication in human periodontal ligament stem cells via MAPK and PI3K pathway. [Abstract]

2022 Mar;93(3):e60-e72. PMID: 34532860
Brain Res Bull

Progesterone Suppresses Cholesterol Esterification in APP/PS1 mice and a cell model of Alzheimer's Disease. [Abstract]

2021 Aug:173:162-173. PMID: 34044033
Biomedicines

Exosome-Mediated Differentiation of Mouse Embryonic Fibroblasts and Exocrine Cells into β-Like Cells and the Identification of Key miRNAs for Differentiation. [Abstract]

2020 Nov 9;8(11):485. PMID: 33182285
Neurochem Res

Polyphenols from Toona sinensiss Seeds Alleviate Neuroinflammation Induced by 6-Hydroxydopamine Through Suppressing p38 MAPK Signaling Pathway in a Rat Model of Parkinson's Disease. [Abstract]

2020 Sep;45(9):2052-2064. PMID: 32556929
J Periodontol

Effect of interleukin-22 on osteogenic differentiation and the osteoclastogenic response of human periodontal ligament fibroblasts in vitro. [Abstract]

2020 Aug;91(8):1085-1097. PMID: 31950496
Biosci Rep

p38 promoted retinal micro-angiogenesis through up-regulated RUNX1 expression in diabetic retinopathy. [Abstract]

2020 May 29;40(5):BSR20193256. PMID: 32319515
Mol Nutr Food Res

Naringenin Exerts Cardiovascular Protective Effect in a Palmitate-Induced Human Umbilical Vein Endothelial Cell Injury Model via Autophagy Flux Improvement. [Abstract]

2019 Dec;63(24):e1900601. PMID: 31622021
Aquaculture

2025 Sep 15.
Aquaculture

2023 Dec 15, 577, 739927.
BMC Complement Med Ther

Hinokiflavone induces apoptosis, cell cycle arrest and autophagy in chronic myeloid leukemia cells through MAPK/NF-κB signaling pathway. [Abstract]

2022 Apr 6;22(1):100. PMID: 35387632
FASEB J

LncRNA DANCR Activates p38/mTOR-Mediated Autophagy via ANXA2 to Exacerbate Oxygen-Induced Retinal Neovascularization in Mice. [Abstract]

2026 Jan 15;40(1):e71364. PMID: 41451441
J Pharmacol Exp Ther

Essential roles of mechanistic target of rapamycin in the induction of steroid resistance in group 2 innate lymphoid cells and severe asthma. [Abstract]

2025 Oct 8;392(11):103744. PMID: 41172625
FASEB J

Stem Cell Membrane Biomimetic Nano-Formulation Achieves the Delivery of MKP5 to Ameliorate Diabetic Kidney Disease via the P38 and ERK Pathway. [Abstract]

2025 Sep 30;39(18):e71045. PMID: 40948363
FASEB J

USP44 Regulates Chemoresistance Induced by ROS and the MAPK/NF-κB Pathway Through the Stabilization of ITGB4 in Gastric Cancer. [Abstract]

2025 Aug 31;39(16):e70945. PMID: 40824171
FASEB J

Activation of SIK2 inhibits gluconeogenesis and alleviates lipogenesis-induced inflammatory response by SIK2-CRTC2-ACC1 in hepatocytes of large yellow croaker (Larimichthys crocea). [Abstract]

2025 Mar 31;39(6):e70393. PMID: 40067199
Biol Trace Elem Res

Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice. [Abstract]

2024 Jun;202(6):2598-2615. PMID: 37702962
Biochim Biophys Acta Mol Cell Res

Treponema pallidum recombinant protein Tp47 enhanced interleukin-6 secretion in human dermal fibroblasts through the toll-like receptor 2 via the p38, PI3K/Akt, and NF-κB signalling pathways. [Abstract]

2023 Oct;1870(7):119540. PMID: 37468070
Antiviral Res

HIV protease inhibitor attenuated astrocyte autophagy involvement in inflammation via p38 MAPK pathway. [Abstract]

2022 Dec:208:105463. PMID: 36372295
Biochim Biophys Acta Mol Cell Res

TSLP-induced collagen type-I synthesis through STAT3 and PRMT1 is sensitive to calcitriol in human lung fibroblasts. [Abstract]

2021 Sep;1868(10):119083. PMID: 34147561
FASEB J

Inhibition of α1-adrenoceptor reduces TGF-β1-induced epithelial-to-mesenchymal transition and attenuates UUO-induced renal fibrosis in mice. [Abstract]

2020 Nov;34(11):14892-14904. PMID: 32939891
FASEB J

Pancreatic cancer-derived exosomes induce apoptosis of T lymphocytes through the p38 MAPK-mediated endoplasmic reticulum stress. [Abstract]

2020 Jun;34(6):8442-8458. PMID: 32350913
FASEB J

Bile acids induce visceral hypersensitivity via mucosal mast cell-to-nociceptor signaling that involves the farnesoid X receptor/nerve growth factor/transient receptor potential vanilloid 1 axis. [Abstract]

2019 Feb;33(2):2435-2450. PMID: 30260705

Adezmapimod purchased from MedChemExpress. Usage Cited in: FASEB J. 2019 Feb;33(2):2435-2450. [Abstract]

Bile acids (BAs) cause nuclear translocation of NF-kB p65, an effect that is abolished by SB203580.
Fish Shellfish Immunol

M1 macrophage polarization induces inflammatory response of adipocytes via MAPK/AKT-PPARγ pathway in large yellow croaker (Larimichthys crocea). [Abstract]

2026 Aug:175:111443. PMID: 42162881
Mol Hum Reprod

Cyclic stretch activates endometrial stromal cells to enhance migration and invasion via mechanosensitive p38 MAPK and F-actin in vitro. [Abstract]

2026 Apr 11;32(2):gaag019. PMID: 41875408
Drug Dev Res

Kaurenoic Acid Suppresses Osteosarcoma Progression by Reprogramming Tumor-Associated Macrophages to M1 Phenotype. [Abstract]

2025 Nov;86(7):e70183. PMID: 41158091
Drug Dev Res

Peimine-induced apoptosis and inhibition of migration by regulating reactive oxygen species-mediated MAPK/STAT3/NF-κB and Wnt/β-catenin signaling pathways in gastric cancer MKN-45 cells. [Abstract]

2022 Nov;83(7):1683-1696. PMID: 36048972
Proteomics

Dynamic Phosphoproteomic Profiling Captured Early Signaling Events for Cold Acclimation in Larval Zebrafish. [Abstract]

2026 May;26(5):69-85. PMID: 41906457
Front Biosci (Landmark Ed)

Bioinformatics-Based Identification and Clinical Validation of CHST1 as a Potential Prognostic Gene Associated With EMT in Gastric Cancer. [Abstract]

2026 Mar 19;31(3):47627. PMID: 41914286
J Virol

The ASFV CD2v protein inhibits apoptosis by inducing proteasomal degradation of BimEL via activation of the TPL2-MEK-ERK signaling pathway. [Abstract]

2026 Mar 24;100(3):e0195225. PMID: 41631827
J Virol

The mRNA and protein of IL-8 oppositely regulate PRRSV replication via nucleoprotein and 14-3-3γ. [Abstract]

2025 Aug 19;99(8):e0065525. PMID: 40704900
Curr Issues Mol Biol

As2S2 Mediates the ROS/P38 MAPK Signaling Pathway to Induce Apoptosis and S-Phase Arrest in Myelodysplastic Syndrome Cells. [Abstract]

2025 Apr 7;47(4):253. PMID: 40699652
Front Biosci (Landmark Ed)

Scutellarin Attenuates Pro-Inflammatory Foam Cell Formation and Facilitates M2 Polarization in Microglia during Copper Homeostasis Imbalance via the MAPK Signaling Pathway. [Abstract]

2025 Mar 6;30(3):36255. PMID: 40152387
Curr Issues Mol Biol

The Electric Field Guided HaCaT Cell Migration Through the EGFR/p38 MAPK/Akt Pathway. [Abstract]

2024 Dec 31;47(1):16. PMID: 39852131
J Virol

Phospho-eIF4E stimulation regulates coronavirus entry by selective expression of cell membrane-residential factors. [Abstract]

2024 Feb 20;98(2):e0194823. PMID: 38299843
Front Biosci (Landmark Ed)

Maintenance of the Expression of c-FLIPL by Hsp70 to Resist Licochalcone A-Induced Anti-Colorectal Cancer Effect through ERK-Mediated Autophagy Induction. [Abstract]

2023 Dec 1;28(12):325. PMID: 38179732
BMC Cancer

ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis. [Abstract]

2023 Nov 14;23(1):1108. PMID: 37964204
J Virol

Critical Role of Viral Protein Hexon in Hypervirulent Fowl Adenovirus Serotype-4-Induced Autophagy by Interaction with BAG3 and Promotion of Viral Replication in LMH Cells. [Abstract]

2023 Jun 29;97(6):e0028423. PMID: 37255472
Chem Res Toxicol

P38 MAPK, NF-κB, and JAK-STAT3 Signaling Pathways Involved in Capecitabine-Induced Hand-Foot Syndrome via Interleukin 6 or Interleukin 8 Abnormal Expression. [Abstract]

2022 Mar 21;35(3):422-430. PMID: 35147423
Mycopathologia

MiR-146a Negatively Regulates Aspergillus fumigatus-Induced TNF-α and IL-6 Secretion in THP-1 Macrophages. [Abstract]

2021 Jun;186(3):341-354. PMID: 34089172
J Biol Chem

Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131). [Abstract]

2019 Apr 19;294(16):6531-6549. PMID: 30804208
J Photochem Photobiol B

Hydroxysafflower yellow a protects against UVA- and UVB-induced skin aging by suppressing cell apoptosis and SASP via targeting JNK and p38 MAPK pathway. [Abstract]

2026 Jan:274:113340. PMID: 41421060
ACS Pharmacol Transl Sci

Antineuroblastoma Activity Evaluation and Mechanism of Novel PD-L1 Small Molecule Inhibitors through Immune and Non-Immune Pathways. [Abstract]

2025 Jul 7;8(8):2612-2629. PMID: 40810160
Naunyn Schmiedebergs Arch Pharmacol

Polydatin protects against leukemia by inducing apoptosis and activating autophagy via p38-MAPK pathway. [Abstract]

2025 Apr 14. PMID: 40229602
Naunyn Schmiedebergs Arch Pharmacol

Kaempferol attenuates cyclosporine-induced renal tubular injury via inhibiting the ROS-ASK1-MAPK pathway. [Abstract]

2025 Mar;398(3):3001-3014. PMID: 39316086
J Endocrinol Invest

Bromocriptine sensitivity in bromocriptine-induced drug-resistant prolactinomas is restored by inhibiting FGF19/FGFR4/PRL. [Abstract]

2025 Jan;48(1):67-80. PMID: 38926262
J Immunol

Hyperosmotic Stress Induces Inflammation and Excessive Th17 Response to Blunt T-Cell Immunity in Tilapia. [Abstract]

2024 Jun 15;212(12):1877-1890. PMID: 38700398
Toxins

Staphylococcal Enterotoxin A Induces Intestinal Barrier Dysfunction and Activates NLRP3 Inflammasome via NF-κB/MAPK Signaling Pathways in Mice. [Abstract]

2022 Jan 1;14(1):29. PMID: 35051006
Toxins

Combined Effect of Deoxynivalenol (DON) and Porcine Circovirus Type 2 (Pcv2) on Inflammatory Cytokine mRNA Expression. [Abstract]

2021 Jun 13;13(6):422. PMID: 34199278
J Cell Physiol

Pak2 inhibition promotes resveratrol-mediated glioblastoma A172 cell apoptosis via modulating the AMPK-YAP signaling pathway. [Abstract]

2020 Oct;235(10):6563-6573. PMID: 32017068
J Cell Physiol

LncRNA-ATB promotes TGF-β-induced glioma cells invasion through NF-κB and P38/MAPK pathway. [Abstract]

2019 Dec;234(12):23302-23314. PMID: 31140621
JOR Spine

Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy. [Abstract]

2024 Apr 17;7(2):e1325. PMID: 38633661
Microb Pathog

Activation of TLR2 heterodimers-mediated NF-κB, MAPK, AKT signaling pathways is responsible for Vibrio alginolyticus triggered inflammatory response in vitro. [Abstract]

2022 Jan:162:105219. PMID: 34601054
Nutr Metab

PA and OA induce abnormal glucose metabolism by inhibiting KLF15 in adipocytes. [Abstract]

2021 Nov 21;18(1):100. PMID: 34802421
Microb Pathog

C-terminal-truncated hepatitis B virus X protein promotes hepatocarcinogenesis by activating the MAPK pathway. [Abstract]

2021 Oct:159:105136. PMID: 34390769
J Funct Foods

2019, 103562.
J Endod

Exosomes with Highly Angiogenic Potential for Possible Use in Pulp Regeneration. [Abstract]

2018 May;44(5):751-758. PMID: 29426641

Adezmapimod purchased from MedChemExpress. Usage Cited in: J Endod. 2018 May;44(5):751-758. [Abstract]

p38 MAPK inhibition enhances DPC-Exos–induced tube formation. (A) p38 MAPK activity is measured by detecting Phospho-p38 MAPK. The ratio between Phospho-p38 MAPK and the p38 MAPK band is used for quantification. (B) The effects of VEGF-A and KDR expression after p38 MAPK inhibitor SB203580 treatment on DPC-Exos-stimulated HUVECs.
Nitric Oxide

Polysulfides derived from the hydrogen sulfide and persulfide donor P* inhibit IL-1β-mediated inducible nitric oxide synthase signaling in ATDC5 cells: are CCAAT/enhancer-binding proteins β and δ involved in the anti-inflammatory effects of hydrogen sulfide and polysulfides?. [Abstract]

2022 Dec 1:129:41-52. PMID: 36216240
Viruses

Inducible miR-150 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Targeting Viral Genome and Suppressor of Cytokine Signaling 1. [Abstract]

2022 Jul 7;14(7):1485. PMID: 35891465
Viruses

Pseudorabies Virus Tegument Protein UL13 Suppresses RLR-Mediated Antiviral Innate Immunity through Regulating Receptor Transcription. [Abstract]

2022 Jul 2;14(7):1465. PMID: 35891444
Vet Res

Glaesserella parasuis serotype 4 HPS4-YC disrupts the integrity of the swine tracheal epithelial barrier and facilitates bacterial translocation. [Abstract]

2021 Oct 21;52(1):135. PMID: 34674760
J Microbiol

NF-κB/ROS and ERK pathways regulate NLRP3 inflammasome activation in Listeria monocytogenes infected BV2 microglia cells. [Abstract]

2021 Aug;59(8):771-781. PMID: 34061343
J Proteome Res

Phosphoproteome Profiling Revealed the Importance of mTOR Inhibition on CDK1 Activation to Further Regulate Cell Cycle Progression. [Abstract]

2021 May 7;20(5):2329-2339. PMID: 33797919
Pathol Res Pract

α-Mangostin protects human brain microvascular endothelial cells from OGD/R-induced damage via regulation of the PDE4D-MAPK pathway. [Abstract]

2026 Jul:283:156490. PMID: 42033866
J Pharm Pharmacol

Formononetin attenuates corticosterone-induced depressive-like behaviors and neuronal damage via ERα/ERK-CREB-BDNF signaling pathway. [Abstract]

2026 Feb 7;78(2):rgag010. PMID: 41697882
J Pharm Pharmacol

Isoliquiritigenin regulates microglial M1/M2 polarisation by mediating the P38/MAPK pathway in cerebral stroke. [Abstract]

2023 Jun 5;75(6):828-836. PMID: 37027320
Parasit Vectors

Giardia duodenalis extracellular vesicles regulate the proinflammatory immune response in mouse macrophages in vitro via the MAPK, AKT and NF-κB pathways. [Abstract]

2021 Jul 8;14(1):358. PMID: 34238339
Mol Immunol

Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264.7 macrophages. [Abstract]

2021 Mar:131:97-111. PMID: 33461765
Mol Immunol

CD8+iTregs attenuate glomerular endothelial cell injury in lupus-prone mice through blocking the activation of p38 MAPK and NF-κB. [Abstract]

2018 Nov:103:133-143. PMID: 30268079
Mol Immunol

TLR2 mediates autophagy through ERK signaling pathway in Mycoplasma gallisepticum-infected RAW264.7 cells. [Abstract]

2017 Jul:87:161-170. PMID: 28478286
Am J Physiol Renal Physiol

Loss of transcription factor ATOH8 activates TGF-β signaling and exacerbates glomerulosclerosis in podocytes. [Abstract]

2026 Feb 1;330(2):F269-F284. PMID: 41545031
Cytokine

Cyanidin attenuates IL-17A cytokine signaling mediated monocyte migration and differentiation into mature osteoclasts in rheumatoid arthritis. [Abstract]

2021 Jun:142:155502. PMID: 33810944
Toxicol Appl Pharmacol

Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways. [Abstract]

2021 May 1:418:115484. PMID: 33716044
Nanotoxicology

Graphene oxide nanoparticles induce hepatic dysfunction through the regulation of innate immune signaling in zebrafish ( Danio rerio). [Abstract]

2020 Jun;14(5):667-682. PMID: 32141807
Toxicol Appl Pharmacol

Protective effect of peptide DR8 on bleomycin-induced pulmonary fibrosis by regulating the TGF-β/MAPK signaling pathway and oxidative stress. [Abstract]

2019 Nov 1:382:114703. PMID: 31398421
Toxicol Appl Pharmacol

M1 macrophage mediated increased reactive oxygen species (ROS) influence wound healing via the MAPK signaling in vitro and in vivo. [Abstract]

2019 Mar 1:366:83-95. PMID: 30690042
Arch Biochem Biophys

FFA intervention on LO2 cells mediates SNX-10 synthesis and regulates MMP9 secretion in LX2 cells via TGF-β1. [Abstract]

2025 Feb:764:110255. PMID: 39662717
Immun Inflamm Dis

Mycobacterium tuberculosis protein Rv2652c enhances intracellular survival by inhibiting host immune responses. [Abstract]

2024 Sep;12(9):e70012. PMID: 39240051
Int J Biochem Cell Biol

Herb pair of Rhubarb-Astragalus mitigates renal interstitial fibrosis through downregulation of autophagy via p38-MAPK/TGF-β1 and p38-MAPK/smad2/3 pathways. [Abstract]

2024 Apr:169:106549. PMID: 38340950
Arch Biochem Biophys

Mechanical stretch facilitates tenomodulin expression to induce tenocyte migration via MAPK signaling pathway. [Abstract]

2023 Jan 15:734:109486. PMID: 36513131
Diabetes Metab Syndr Obes

RPS4Y1 Promotes High Glucose-Induced Endothelial Cell Apoptosis and Inflammation by Activation of the p38 MAPK Signaling. [Abstract]

2021 Nov 12;14:4523-4534. PMID: 34803387
Int J Biochem Cell Biol

Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) inhibits cutaneous squamous cell carcinoma cell proliferation via targeting PP2A/PP5-mediated MAPK signaling pathway. [Abstract]

2021 Aug:137:106036. PMID: 34217813
Int J Biochem Cell Biol

Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission. [Abstract]

2021 Jul:136:106003. PMID: 33971320
Bioorg Med Chem

Broad assessment of bioactivity of a collection of spiroindane pyrrolidines through "cell painting". [Abstract]

2020 Jul 1;28(13):115547. PMID: 32546297
Vaccines

Polyamine Transport Protein PotD Protects Mice against Haemophilus parasuis and Elevates the Secretion of Pro-Inflammatory Cytokines of Macrophage via JNK-MAPK and NF-κB Signal Pathways through TLR4. [Abstract]

2019 Dec 14;7(4):216. PMID: 31847381
Peptides

Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway. [Abstract]

2019 Sep:119:170120. PMID: 31351089
Mol Cell Endocrinol

Adiponectin upregulates irisin expression through the APPL1/p38MAPK/PGC-1α signalling pathway in murine skeletal muscle. [Abstract]

2026 Jun:616:112743. PMID: 41654165
Andrology

Expression of IL-33 in rodent testes and its role in Leydig cell steroidogenesis and aging. [Abstract]

2025 Jun 16. PMID: 40521800
J Leukoc Biol

Nervonic acid mitigates IMQ-triggered psoriasis in mice via inhibiting Th17/γδT17 cell invasion and modulating the gut microbiota. [Abstract]

2025 Jun 4;117(6):qiaf070. PMID: 40397706
Brain Sci

The Role of p38 Mitogen-Activated Protein Kinase-Mediated F-Actin in the Acupuncture-Induced Mitigation of Inflammatory Pain in Arthritic Rats. [Abstract]

2024 Apr 14;14(4):380. PMID: 38672029
J Leukoc Biol

Transient receptor potential vanilloid 4 (TRPV4) in neutrophils enhances myocardial ischemia/reperfusion injury. [Abstract]

2023 Sep 1;114(3):266-279. PMID: 37232941
Brain Sci

Dexmedetomidine Improves Anxiety-like Behaviors in Sleep-Deprived Mice by Inhibiting the p38/MSK1/NFκB Pathway and Reducing Inflammation and Oxidative Stress. [Abstract]

2023 Jul 11;13(7):1058. PMID: 37508990
Infect Immun

Annexin A1 Attenuates Neutrophil Migration and IL-6 Expression through Fpr2 in a Mouse Model of Streptococcus suis-Induced Meningitis. [Abstract]

2021 Feb 16;89(3):e00680-20. PMID: 33318141
Phytochemistry

Sesquiterpene coumarins from Ferula sinkiangensis K.M.Shen and their cytotoxic activities. [Abstract]

2020 Dec:180:112531. PMID: 33010535
Front Oncol

Baoyuan Jiedu Decoction Alleviates Cancer-Induced Myotube Atrophy by Regulating Mitochondrial Dynamics Through p38 MAPK/PGC-1α Signaling Pathway. [Abstract]

2020 Sep 30:10:523577. PMID: 33102208
Mol Cell Endocrinol

Rapid effect of bisphenol A on glutamate-induced Ca2+ influx in hippocampal neurons of rats. [Abstract]

2019 Apr 5:485:35-43. PMID: 30707916
Mol Cell Endocrinol

Bisphenol A affects trophoblast invasion by inhibiting CXCL8 expression in decidual stromal cells. [Abstract]

2018 Jul 15:470:38-47. PMID: 28736254
Cell Immunol

House dust mite allergen directly activates ILC2 cells via the TLR4 signaling pathway in allergic airway diseases. [Abstract]

2024 Nov-Dec:405-406:104884. PMID: 39437527
J Physiol Sci

Acupuncture improves spatial learning and memory impairment caused by herpes simplex virus type-1 in rats through the p38 MAPK/CREB pathway. [Abstract]

2024 Oct 3;74(1):49. PMID: 39363248
Int J Food Sci Tech

2024 Jul 18.
Cell Immunol

Rac1 plays a crucial role in MCP-1-induced monocyte adhesion and migration. [Abstract]

2024 Jun 17:401-402:104843. PMID: 38905771
Neuroscience

ATP Stimulation Promotes Functional Recovery after Intracerebral Haemorrhage by Increasing the mBDNF/proBDNF Ratio. [Abstract]

2021 Apr 1:459:104-117. PMID: 33421569
Endocrine

Inhibition of thioredoxin 2 by intracellular methylglyoxal accumulation leads to mitochondrial dysfunction and apoptosis in INS-1 cells. [Abstract]

2020 Apr;68(1):103-115. PMID: 31939094
Mol Biol Rep

Nicotinamide mononucleotide and nicotinamide riboside attenuate cytokine production in human keratinocytes via suppression of p38 Pathway. [Abstract]

2026 Mar 4;53(1):459. PMID: 41779073
Mol Biol Rep

17β-estradiol inhibits Notch1 activation in murine macrophage cell line RAW 264.7. [Abstract]

2024 Nov 8;51(1):1134. PMID: 39514048
Food Chem Toxicol

L-theanine attenuates H2O2-induced inflammation and apoptosis in IPEC-J2 cells via inhibiting p38 MAPK signaling pathway. [Abstract]

2024 Apr:186:114561. PMID: 38438008
Food Chem Toxicol

L-theanine attenuates porcine intestinal tight junction damage induced by LPS via p38 MAPK/NLRP3 signaling in IPEC-J2 cells. [Abstract]

2023 Aug:178:113870. PMID: 37271275
Food Chem Toxicol

Hydrogen sulfide protects Sertoli cells against toxicant Acrolein-induced cell injury. [Abstract]

2023 Jun:176:113784. PMID: 37059385
Food Chem Toxicol

Pine pollen extract alleviates ethanol-induced oxidative stress and apoptosis in HepG2 cells via MAPK signaling. [Abstract]

2023 Jan:171:113550. PMID: 36476398
Food Chem Toxicol

G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes. [Abstract]

2021 Feb:148:111925. PMID: 33359794
J Immunol Res

Chloroquine and Rapamycin Augment Interleukin-37 Expression via the LC3, ERK, and AP-1 Axis in the Presence of Lipopolysaccharides. [Abstract]

2020 Feb 10:2020:6457879. PMID: 32104716
J Appl Toxicol

Exposure to Polyethylene Terephthalate Microplastic Induces Mouse Liver Fibrosis Through Oxidative Stress and p38 MAPK/p65 NF-κB Signaling Pathway. [Abstract]

2025 Sep;45(9):1694-1704. PMID: 40312270
Free Radic Res

Thioredoxin improves contact dermatitis through an anti-inflammatory mechanism different from glucocorticoids. [Abstract]

2025 May-Jul;59(6-7):518-530. PMID: 40679915
Tissue Cell

Momordica cochinchinensis extract alleviates oxidative stress and skin damage caused by fine particulate matter. [Abstract]

2024 Oct:90:102496. PMID: 39098256
Chin J Integr Med

p38 Signaling Mediates Naringin-Induced Osteogenic Differentiation of Porcine Metanephric Mesenchymal Cells. [Abstract]

2024 Sep;30(9):818-825. PMID: 38850479
Toxicol Lett

Co-exposure to polystyrene microplastics and di-(2-ethylhexyl) phthalate aggravates allergic asthma through the TRPA1-p38 MAPK pathway. [Abstract]

2023 Aug 1:384:73-85. PMID: 37500026
Exp Eye Res

A novel model of subretinal edema induced by DL-alpha aminoadipic acid. [Abstract]

2023 Mar:228:109388. PMID: 36652968
J Neurol Sci

Attenuation of paraquat-induced inflammation by inhibitors of phosphorylation of mitogen-activated protein kinases in BV2 microglial cells. [Abstract]

2020 Mar 15:410:116679. PMID: 31951835
BMC Pulm Med

Role of TLR4-p38 MAPK-Hsp27 signal pathway in LPS-induced pulmonary epithelial hyperpermeability. [Abstract]

2018 Nov 27;18(1):178. PMID: 30482200

Adezmapimod purchased from MedChemExpress. Usage Cited in: BMC Pulm Med. 2018 Nov 27;18(1):178. [Abstract]

P-p38 and P-Hsp27 are detected by western blotting with the treatment of LPS, SB203580 and SB203580+ LPS.

Adezmapimod purchased from MedChemExpress. Usage Cited in: BMC Pulm Med. 2018 Nov 27;18(1):178. [Abstract]

P-p38 and P-Hsp27 are detected by western blotting with the treatment of LPS, SB203580 and SB203580+ LPS.
Hum Mol Genet

BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter. [Abstract]

2017 Sep 15;26(18):3553-3563. PMID: 28655168

Adezmapimod purchased from MedChemExpress. Usage Cited in: Hum Mol Genet. 2017 Sep 15;26(18):3553-3563. [Abstract]

Immunofluorescence analysis for expression of the I-cell marker ΔNP63 on proximal sections of ureters explanted from E12.5 wildtype (control) embryos and cultured for 6 d in the presence of solvent (DMSO) (A), the AKT inhibitor (AKT-i) MK2206 (B), the P38 inhibitor (P38-i) SB203580 (C), the ERK1/2 inhibitor (ERK1/2-i) PD98059 (D) or combinations as indicated (E and F).
Am J Physiol Gastrointest Liver Physiol

Regulatory T cells are induced by gut microbiota through differentially regulating costimulatory molecules of enteric glial cells. [Abstract]

2026 May 1;330(5):G532-G548. PMID: 41711540
Exp Physiol

Resistance of osteosarcoma cells to the proapoptotic effects of carfilzomib involves activation of mitogen activated protein kinase pathways. [Abstract]

2021 Feb;106(2):438-449. PMID: 33336554
J Cell Biochem

MicroRNA-543 promotes ovariectomy-induced osteoporosis through inhibition of AKT/p38 MAPK signaling pathway by targeting YAF2. [Abstract]

2019 May;120(5):8561-8569. PMID: 30506950

Adezmapimod purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2019 May;120(5):8561-8569. [Abstract]

Western analysis of protein expression in the treatment of miR-543 and SB 203580.
J Cell Biochem

Epiregulin promotes the migration and chemotaxis ability of adipose-derived mesenchymal stem cells via mitogen-activated protein kinase signaling pathways. [Abstract]

2018 Nov;119(10):8450-8459. PMID: 30011072

Adezmapimod purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2018 Nov;119(10):8450-8459. [Abstract]

Western blot results show a reduction in phosphorylated p38 MAPK in ADSCs after treatment with 20 μM SB203580, 20 μM SP600125, or 20 μM PD98059 for 1 hour.
Theriogenology

Rap1b is a critical regulator of germinal vesicle breakdown in porcine oocytes. [Abstract]

2026 Mar 1:252:117791. PMID: 41420899
BMC Immunol

Tacrolimus reverses pemphigus vulgaris serum-induced depletion of desmoglein in HaCaT cells via inhibition of heat shock protein 27 phosphorylation. [Abstract]

2023 Nov 8;24(1):43. PMID: 37940861
PeerJ

CTRP3 attenuates inflammation, oxidative and cell death in cisplatin induced HK-2 cells. [Abstract]

2023 Aug 23:11:e15890. PMID: 37637169
Chem Biodivers

Pristimerin Induces Autophagy-Mediated Cell Death in K562 Cells through the ROS/JNK Signaling Pathway. [Abstract]

2019 Aug;16(8):e1900325. PMID: 31290253
Biomed Res Int

p38/TF/HIF- α Signaling Pathway Participates in the Progression of CIPN in Mice. [Abstract]

2019 Jul 10:2019:5347804. PMID: 31380428
Vet Microbiol

AS-IV exhibits anti-SADS-CoV effects through the inhibition of the MAPK/JNK signaling pathway mediated by the S1 protein. [Abstract]

2026 Feb:313:110858. PMID: 41477941
Vet Microbiol

Streptococcus suis employs the Ihk/Irr-PepO axis to subvert macrophage actin polymerization: A novel anti-phagocytic strategy enhancing bacterial virulence. [Abstract]

2025 Sep 11:310:110726. PMID: 40946614
Toxicon

Dimethyl ester of bilirubin ameliorates Naja naja snake venom-induced lung toxicity in mice via inhibiting NLRP3 inflammasome and MAPKs activation. [Abstract]

2024 Jun:244:107757. PMID: 38740099
Int J Immunopathol Pharmacol

Low-dose metformin suppresses hepatocellular carcinoma metastasis via the AMPK/JNK/IL-8 pathway. [Abstract]

2024 Jan-Dec:38:3946320241249445. PMID: 38679570
Pharmacology

Dexmedetomidine Attenuates Hypoxia/Reoxygenation Injury of H9C2 Myocardial Cells by Upregulating miR-146a Expression via the MAPK Signal Pathway. [Abstract]

2022;107(1-2):14-27. PMID: 34718238
Vet Microbiol

Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) induces IL-6 production through TAK-1/JNK/AP-1 and TAK-1/NF-κB signaling pathways. [Abstract]

2021 May:256:109061. PMID: 33836390
PLoS One

Mechanical stretching of pulmonary vein stimulates matrix metalloproteinase-9 and transforming growth factor-β1 through stretch-activated channel/MAPK pathways in pulmonary hypertension due to left heart disease model rats. [Abstract]

2020 Sep 3;15(9):e0235824. PMID: 32881898
Acupunct Med

Electroacupuncture alleviates the transition from acute to chronic pain through the p38 MAPK/TNF-α signalling pathway in the spinal dorsal horn. [Abstract]

2021 Dec;39(6):708-715. PMID: 34308662
Fundam Clin Pharmacol

Activation of RAW264.7 macrophage by Exopolysaccharide from Aphanothece halaphytica (EPSAH) and the underlying mechanisms. [Abstract]

2020 Oct;34(5):591-602. PMID: 32083746
FEBS Open Bio

Low-intensity pulsed ultrasound inhibits VEGFA expression in chondrocytes and protects against cartilage degeneration in experimental osteoarthritis. [Abstract]

2020 Mar;10(3):434-443. PMID: 31975545
J Mol Histol

Neferine induces cell growth inhibition and apoptosis via ROS-mediated activation of p38 in pancreatic ductal adenocarcinoma cells. [Abstract]

2025 Jul 31;56(4):246. PMID: 40742573
DNA Cell Biol

Histidine Kinase QseC in Glaesserella parasuis Enhances the Secretion of Proinflammatory Cytokines by Macrophages via the p38 and NF-κB Signaling Pathways. [Abstract]

2024 Sep;43(9):474-481. PMID: 39049814
Cell Microbiol

Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism. [Abstract]

2019 Sep;21(9):e13064. PMID: 31155820
Virology

PD169316, a specific p38 inhibitor, shows antiviral activity against Enterovirus71. [Abstract]

2017 Aug:508:150-158. PMID: 28545002
Future Sci OA

TWEAK/Fn14 axis may promote vascular smooth muscle cell senescence via p38 signaling pathway: preliminary evidence. [Abstract]

2025 Dec;11(1):2455906. PMID: 39840833
Cancer Rep (Hoboken)

RALYL Overexpression Suppresses Colorectal Cancer via Modulating HNRNPC-Mediated MNK2 Alternative Splicing. [Abstract]

2025 Mar;8(3):e70179. PMID: 40052233
Anal Cell Pathol

Transgelin-2 Involves in the Apoptosis of Colorectal Cancer Cells Induced by Tanshinone-IIA. [Abstract]

2022 Sep 27;2022:9358583. PMID: 36204303
Biochem Biophys Res Commun

ROS/p38MAPK-induced lamin B1 accumulation promotes chronic kidney disease-associated vascular smooth muscle cells senescence. [Abstract]

2020 Oct 15;531(2):187-194. PMID: 32788068
Med Sci Monit

Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer. [Abstract]

2020 Aug 7:26:e925298. PMID: 32764530
Med Sci Monit

Improvement of Gut Microbiota by Inhibition of P38 Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Rats with Severe Acute Pancreatitis. [Abstract]

2019 Jun 21:25:4609-4616. PMID: 31226101
Cell Physiol Biochem

Clostridium Tyrobutyricum Protect Intestinal Barrier Function from LPS-Induced Apoptosis via P38/JNK Signaling Pathway in IPEC-J2 Cells. [Abstract]

2018;46(5):1779-1792. PMID: 29705796

Adezmapimod purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2018;46(5):1779-1792. [Abstract]

Western blot bands of p38, phospho-p38, ZO-1, Clau-din-1, and Occludin. JNK inhibitor SP600125 and p38 inhibitor SB203580 are used.
Dev Comp Immunol

Vibrio harveyi infections induce production of proinflammatory cytokines in murine peritoneal macrophages via activation of p38 MAPK and NF-κB pathways, but reversed by PI3K/AKT pathways. [Abstract]

2022 Feb:127:104292. PMID: 34656643
Onco Targets Ther

18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells. [Abstract]

2021 Oct 22;14:5131-5144. PMID: 34712051
Eur Arch Otorhinolaryngol

Heat shock protein 70 is induced by pepsin via MAPK signaling in human nasal epithelial cells. [Abstract]

2019 Mar;276(3):767-774. PMID: 30600344
Arch Oral Biol

Investigating the mechanism of berberine in inhibiting periodontitis progression using machine learning, molecular docking, and experimental validation. [Abstract]

2026 Mar:183:106496. PMID: 41544413
J Oral Pathol Med

Angiopoietin-like 4 is upregulated by amphiregulin and activates cell proliferation and migration through p38 kinase in head and neck squamous cell carcinoma. [Abstract]

2024 Jul;53(6):366-375. PMID: 38763759
Cytotechnology

Panax notoginseng-Bletilla striata ameliorates reflux esophagitis by modulating NLRP3 inflammasomes and p38 MAPK pathway. [Abstract]

2026 Feb;78(1):3. PMID: 41280658
Neurosci Lett

Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats. [Abstract]

2024 Jan 18:820:137611. PMID: 38142925
Exp Ther Med

LPS inhibits TRIM65 expression in macrophages and C57BL/6J mouse by activating the ERK1/2 signaling pathway. [Abstract]

2023 Mar 14;25(4):188. PMID: 37021067
Exp Ther Med

Theaflavin-3,3'-digallate attenuates cigarette smoke extract-induced pulmonary emphysema in mice by suppressing necroptosis. [Abstract]

2022 Jan;23(1):11. PMID: 34815763
Exp Ther Med

Vicenin 3 ameliorates ECM degradation by regulating the MAPK pathway in SW1353 chondrocytes. [Abstract]

2021 Dec;22(6):1461. PMID: 34737801
Exp Ther Med

Low-doses of aspirin promote the growth of human PC-9 lung cancer cells through activation of the MAPK family. [Abstract]

2021 Dec;22(6):1440. PMID: 34721682
Exp Ther Med

Quercetin suppresses apoptosis of chondrocytes induced by IL-1β via inactivation of p38 MAPK signaling pathway. [Abstract]

2021 May;21(5):468. PMID: 33767763
Exp Ther Med

CTRP3 induces an intermediate switch of CD14++CD16+ monocyte subset with anti-inflammatory phenotype. [Abstract]

2020 Mar;19(3):2243-2251. PMID: 32104290
Exp Ther Med

Resveratrol inhibits LPS-induced inflammation through suppressing the signaling cascades of TLR4-NF-κB/MAPKs/IRF3. [Abstract]

2020 Mar;19(3):1824-1834. PMID: 32104238
Biochem Cell Biol

Promoting effect of lactoferrin on barrier function and epithelial differentiation of human keratinocytes. [Abstract]

2017 Feb;95(1):64-68. PMID: 28165292

Adezmapimod purchased from MedChemExpress. Usage Cited in: Biochem Cell Biol. 2017 Feb;95(1):64-68. [Abstract]

The involvement of the p38 MAPK signaling pathways in lactoferrin-induced differentiation of HaCaT keratinocytes. HaCaT cells are differentiated in the presence or absence of 10 μM bovine Lactoferrin for 5 days. PD98059 (40 μM), SB203580 (10 μM), or LY294002 (10 μM) are added at the same time. Cell differentiation is evaluated by the expression levels of Involucrin and Filaggrin. GAPDH is used as a loading control.
Oncol Lett

IL-37 drives temozolomide resistance in glioblastoma via MAPK pathway activation. [Abstract]

2026 Jun 3;32(2):322. PMID: 42290671
Can Respir J

Effects of Different Intervention Factors on Vascular Endothelial Growth Factor-Induced Human Airway Smooth Muscle Cell Migration. [Abstract]

2022 Oct 10:2022:6879539. PMID: 36262381
Oncol Lett

Autophagy suppresses resveratrol-induced apoptosis in renal cell carcinoma 786-O cells. [Abstract]

2020 Apr;19(4):3269-3277. PMID: 32256822
Genes Genomics

TSTA3 promotes the malignant progression of bladder cancer by regulating LAMP2 and MAPK signaling pathway-mediated epithelial-mesenchymal transition. [Abstract]

2026 Jan 14. PMID: 41533307
Anticancer Drugs

WDR62 mediates MAPK/ERK pathway to stimulate DNA damage repair and attenuate cisplatin sensitivity in lung adenocarcinoma. [Abstract]

2025 Apr 1;36(4):319-327. PMID: 39808528
Cell J

CTRP1 Aggravates Cardiac Fibrosis by Regulating The NOX2/P38 Pathway in Macrophages. [Abstract]

2022 Dec 1;24(12):732-740. PMID: 36527345
Connect Tissue Res

Neferine alleviates ovariectomy-induced osteoporosis by enhancing osteogenic differentiation of bone marrow mesenchymal stem cells via regulation of the p38MAPK pathway. [Abstract]

2024 May;65(3):253-264. PMID: 38753365
J Interferon Cytokine Res

HDAC9 in the Injury of Vascular Endothelial Cell Mediated by P38 MAPK Pathway. [Abstract]

2021 Dec;41(12):439-449. PMID: 34935488
J Clin Neurosci

Effects of p38 MAPK signaling pathway on cognitive function and recovery of neuronal function after hypoxic-ischemic brain injury in newborn rats. [Abstract]

2020 Aug:78:365-370. PMID: 32360159
J Interferon Cytokine Res

MCP-1/CCL2 Mediated by Autocrine Loop of PDGF-BB Promotes Invasion of Lung Cancer Cell by Recruitment of Macrophages Via CCL2-CCR2 Axis. [Abstract]

2019 Apr;39(4):224-232. PMID: 30730243
J Vet Sci

Subcutaneous Streptococcus dysgalactiae GAPDH vaccine in mice induces a proficient innate immune response. [Abstract]

2023 Sep;24(5):e72. PMID: 38031651
Biol Pharm Bull

Phosphatidylserine-Specific Phospholipase A1 Alleviates Lipopolysaccharide-Induced Macrophage Inflammation by Inhibiting MAPKs Activation. [Abstract]

2022 Aug 1;45(8):1061-1068. PMID: 35650027
Am J Transl Res

Platelet-derived PDGF promotes the invasion and metastasis of cholangiocarcinoma by upregulating MMP2/MMP9 expression and inducing EMT via the p38/MAPK signalling pathway. [Abstract]

2020 Jul 15;12(7):3577-3595. PMID: 32774720
Am J Transl Res

Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis. [Abstract]

2020 Feb 15;12(2):478-492. PMID: 32194897
Am J Transl Res

SXBX pill suppresses homocysteine-induced vascular smooth muscle cells dedifferentiation by inhibiting NLRP3 inflammasomes activation via ERK/p38 MAPK pathways. [Abstract]

2019 Feb 15;11(2):806-818. PMID: 30899381
Reprod Domest Anim

Vitamin E regulates bovine granulosa cell apoptosis via NRF2-mediated defence mechanism by activating PI3K/AKT and ERK1/2 signalling pathways. [Abstract]

2021 Aug;56(8):1066-1084. PMID: 33978262
J Surg Res

Hypoxia Postconditioning Attenuates Hypoxia-Induced Inflammation and Endothelial Barrier Dysfunction. [Abstract]

2024 Jul 22:301:413-422. PMID: 39042975
J Cardiothorac Surg

Mechanical stretching of the pulmonary vein mediates pulmonary hypertension due to left heart disease by regulating SAC/MAPK pathway and the expression of IL-6 and TNF-α. [Abstract]

2021 May 10;16(1):127. PMID: 33971931
J Asian Nat Prod Res

Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death. [Abstract]

2020 Sep;22(9):850-863. PMID: 31345059
Biomed Res

2017; 28 (8): 3383-3386

Adezmapimod purchased from MedChemExpress. Usage Cited in: Biomed Res. 2017; 28 (8): 3383-3386

Effects of various protease inhibitors on HO-1 and P-gp protein expressions.
Mol Cell Toxicol (2019) 15:209-219
Eur J Integr Med

2024 Sep 8.
J Vet Med Sci

Resveratrol can induce differentiating phenotypes in canine oral mucosal melanoma cells. [Abstract]

2023 Jul 1;85(7):721-726. PMID: 37225449
Pharmacogn Mag

2025 May 27.
Int J Clin Exp Med

2017;10(9):13542-13549.

Adezmapimod purchased from MedChemExpress. Usage Cited in: Int J Clin Exp Med. 2017;10(9):13542-13549.

SB203580 decreases the expression ratio of p-p38 and p38 to inhibit activation of p38 MARK pathway.
SSRN

2026 May 12.
Res Sq

2026 May 31.
bioRxiv

2026 Feb 10.
bioRxiv

2026 Jan 25.
Res Sq

2026 Jan 9.
SSRN

2025 Oct 9.
Res Sq

2025 Aug 08.
Josip Juraj Strossmayer University of Osijek

2025.
Washington State University

2025.
University of Minnesota

2025.
bioRxiv

2025 January 18.
Research Square Preprint

2024 Aug 21.
Environ Toxicol

The Novel Application of EUK-134 in Retinal Degeneration: Preventing Mitochondrial Oxidative Stress-Triggered Retinal Pigment Epithelial Cell Apoptosis by Suppressing MAPK/p53 Signaling Pathway. [Abstract]

2025 Jan;40(1):88-100. PMID: 39268877
Res Sq

2024 Oct 15.
Authorea

2024 Jul 13.
Res Sq

2024 Jun 19.
Biomed Pharmacother

Lapatinib combined with doxorubicin causes dose-dependent cardiotoxicity partially through activating the p38MAPK signaling pathway in zebrafish embryos. [Abstract]

2024 Jun:175:116637. PMID: 38653111
bioRxiv

2024 May 2.
Research Square Preprint

2024 Mar 29.
SSRN

2024 Feb 15.
Pak J Zool

2023 Nov 17.
Sci Total Environ

Chlorpyrifos induces placental oxidative stress and barrier dysfunction by mediating mitochondrial apoptosis via the ERK/MAPK signaling pathway: In vitro and in vivo studies. [Abstract]

2023 Dec 10:903:166449. PMID: 37634732
Environ Toxicol

1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/Akt pathway in vitro. [Abstract]

2023 Nov;38(11):2621-2631. PMID: 37466199
Research Square Preprint

2023 Nov 10.
Biomed Pharmacother

Puerarin improves busulfan-induced disruption of spermatogenesis by inhibiting MAPK pathways. [Abstract]

2023 Sep:165:115231. PMID: 37516022
bioRxiv

Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice. [Abstract]

2023 Sep 29:2023.09.27.559864. PMID: 37808846
bioRxiv

2023 Aug 14.
SSRN

2023 May 8.
bioRxiv

2023 Mar 24.
Environ Toxicol

Thymoquinone induces apoptosis in temozolomide-resistant glioblastoma cells via the p38 mitogen-activated protein kinase signaling pathway. [Abstract]

2023 Jan;38(1):90-100. PMID: 36176197
Research Square Print

November 29th, 2022.
Authorea

2022.
Authorea

2022.
Research Square Print

November 15th, 2022
Research Square Print

September 20th, 2022.
Aging (Albany NY)

Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway. [Abstract]

2022 Aug 5;14(15):6149-6168. PMID: 35939336
Research Square Print

2022 Aug.
Oxid Med Cell Longev

HSPA12A Stimulates p38/ERK-AP-1 Signaling to Promote Angiogenesis and Is Required for Functional Recovery Postmyocardial Infarction. [Abstract]

2022 Jun 22:2022:2333848. PMID: 35783189
Research Square Preprint

2022 May.
Bioengineered

Echinococcus multilocularis drives the polarization of macrophages by regulating the RhoA-MAPK signaling pathway and thus affects liver fibrosis. [Abstract]

2022 Apr;13(4):8747-8758. PMID: 35324411
Oxid Med Cell Longev

Human Papillomavirus Type 16 Early Protein E7 Activates Autophagy through Inhibition of Dual-Specificity Phosphatase 5. [Abstract]

2022 Mar 10:2022:1863098. PMID: 35368866
Int J Biol Sci

Cancer-associated adipocytes promote the invasion and metastasis in breast cancer through LIF/CXCLs positive feedback loop. [Abstract]

2022 Jan 16;18(4):1363-1380. PMID: 35280694
Research Square Preprint

2022 Jan.
Research Square Preprint

2022 Feb.
bioRxiv

January 18, 2022.
Research Square Preprint

2021 Dec.
SSRN

8 Nov 2021.
Research Square Preprint

2021 Oct.
Research Square Preprint

2021 Sep.
Research Square Preprint

2021 Sep.
Research Square Preprint

2021 May.
Research Square Preprint

2021 May.
Aging (Albany NY)

CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis. [Abstract]

2021 May 11;13(9):12780-12799. PMID: 33973871
Aging (Albany NY)

Redd1 knockdown prevents doxorubicin-induced cardiac senescence. [Abstract]

2021 May 6;13(10):13788-13806. PMID: 33962393
Environ Toxicol

Molecular mechanisms of quinalizarin induces apoptosis and G0/G1 cell cycle of human esophageal cancer HCE-4 cells depends on MAPK, STAT3, and NF-κB signaling pathways. [Abstract]

2021 Feb;36(2):276-286. PMID: 33030807
Research Square Preprint

2021 Jan.
Aging (Albany NY)

SRT2183 impairs ovarian cancer by facilitating autophagy. [Abstract]

2020 Nov 20;12(23):24208-24218. PMID: 33223507
Chemosphere

Protective effects and molecular mechanisms of baicalein on thioacetamide-induced toxicity in zebrafish larvae. [Abstract]

2020 Oct:256:127038. PMID: 32470728
Biomed Pharmacother

Colchicine prevents atrial fibrillation promotion by inhibiting IL-1β-induced IL-6 release and atrial fibrosis in the rat sterile pericarditis model. [Abstract]

2020 Sep:129:110384. PMID: 32554248
Universidad de Granada

2020 Sep.
bioRxiv

2020 Jun.
Biomed Pharmacother

Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis via the blockage of p38 and JNK MAPKs. [Abstract]

2020 Mar:123:109752. PMID: 31924596
Biomed Pharmacother

Involvement of the p38 MAPK-pHsp27 pathway in vascular hyporeactivity induced by obstructive jaundice in rats. [Abstract]

2020 Jan:121:109304. PMID: 31810142
Biomed Pharmacother

CTRP3 acts as a novel regulator in depressive-like behavior associated inflammation and apoptosis by meditating p38 and JNK MAPK signaling. [Abstract]

2019 Dec:120:109489. PMID: 31629950
Ann Transl Med

Upregulated miR-155 inhibits inflammatory response induced by C. albicans in human monocytes derived dendritic cells via targeting p65 and BCL-10. [Abstract]

2019 Dec;7(23):758. PMID: 32042774
Eur Rev Med Pharmacol Sci

Melatonin inhibits the inflammation and apoptosis in rats with diabetic retinopathy via MAPK pathway. [Abstract]

2019 Aug;23(3 Suppl):1-8. PMID: 31389568
BMC Complement Altern Med

Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH-1) through p38 MAPK-FOXO3a pathway. [Abstract]

2019 Aug 29;19(1):233. PMID: 31464618
Biomed Pharmacother

Mechanical stretch aggravates aortic dissection by regulating MAPK pathway and the expression of MMP-9 and inflammation factors. [Abstract]

2018 Dec:108:1294-1302. PMID: 30372831

Adezmapimod purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Dec:108:1294-1302. [Abstract]

The protein levels of IL-1β and TNF-α are sharply downregulated by the addition of inhibitors SB203580, SP600125, and U0126.

Adezmapimod purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Dec:108:1294-1302. [Abstract]

The protein level of MMP-9 is downregulated by inhibitors SB203580, SP600125, and U0126.

Adezmapimod purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Dec:108:1294-1302. [Abstract]

As for both 0 g and 3 g groups, the p-ERK1/2/ERK1/2 is notably reduced by inhibitors SB203580, SP600125, and U0126.

Adezmapimod purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Dec:108:1294-1302. [Abstract]

As for both 0 g and 3 g groups, the p-p38&p38 is downregulated by inhibitors SB203580, SP600125, and U0126.

Adezmapimod purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Dec:108:1294-1302. [Abstract]

As for both 0 g and 3 g groups, the p-JNK1&JNK1 is downregulated by inhibitors SB203580, SP600125, and U0126.
Patent

US20180263995A1.
Dis Markers

Knockdown of Heparanase Suppresses Invasion of Human Trophoblasts by Activating p38 MAPK Signaling Pathway. [Abstract]

2018 Apr 17:2018:7413027. PMID: 29849826
Neuropsychiatry (London)

2018;8(4);1132-1139.
Patent

US20170349880A1.
Oncotarget

Tomentodione M sensitizes multidrug resistant cancer cells by decreasing P-glycoprotein via inhibition of p38 MAPK signaling. [Abstract]

2017 Oct 19;8(60):101965-101983. PMID: 29254218

Adezmapimod purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Oct 19;8(60):101965-101983. [Abstract]

Representative western blot analysis of P-gp, p38 MAPK and phospho-p38 MAPK expression in MCF-7/MDR and K562/MDR cells treated with 10 μM SB203580 for 48 hr.
Manchester Metropolitan University

2017 May.
Oxid Med Cell Longev

Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways. [Abstract]

2017:2017:6175841. PMID: 28367270

Adezmapimod purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2017:2017:6175841. [Abstract]

Involvements of MAPK signaling pathway in CPS-induced apoptosis in ALI cultures of sheep bronchial epithelial cells. Cells are pretreated with SB203580 (a P38 inhibitor, 20 μM) for 1 h, followed by exposure to CPS (100 ng/mL) or MO (MOI = 30) for 48 h. Cell lysates are subjected to Western blotting analysis using indicated antibodies.
China Biotechnology

2017, 37(12): 40-48.

Adezmapimod purchased from MedChemExpress. Usage Cited in: China Biotechnology. 2017, 37(12): 40-48.

The Western blot analysis of HOG1 and Phospho-HOG1.
Elife

Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. [Abstract]

2016 Apr 11:5:e14087. PMID: 27063938
Chin Arch Otolaryngol Head Neck Surg

2016,23(01):49-52.

Adezmapimod purchased from MedChemExpress. Usage Cited in: Chin Arch Otolaryngol Head Neck Surg. 2016,23(01):49-52.

Effect of p38MAPK inhibitor on the soft palate reconstruction of the rats with chronic intermittent hypoxia.

용액&용해도

In Vitro:

DMSO : 20 mg/mL (52.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6495 mL

13.2475 mL

26.4950 mL

5 mM

0.5299 mL

2.6495 mL

5.2990 mL

10 mM

0.2649 mL

1.3247 mL

2.6495 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 5% DMSO 40% PEG300 5% Tween-80 50% Saline

Solubility: ≥ 2.5 mg/mL (6.62 mM); Clear solution

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2 mg/mL (5.30 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 3

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2 mg/mL (5.30 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 4

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2 mg/mL (5.30 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 5

Add each solvent one by one: 2% DMSO 40% PEG300 5% Tween-80 53% Saline

Solubility: ≥ 1 mg/mL (2.65 mM); Clear solution

Protocol 6

Add each solvent one by one: 2% DMSO 98% (20% SBE-β-CD in Saline)

Solubility: ≥ 1 mg/mL (2.65 mM); Clear solution

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 10 mg/mL (26.49 mM); Suspended solution; Need ultrasonic

Protocol 2

Add each solvent one by one: 0.5% CMC-Na/saline water

Solubility: 16.67 mg/mL (44.17 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. [Content Brief]

[2]. Lali FV, et al. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J Biol Chem. 2000 Mar 10;275(10):7395-402. [Content Brief]

[3]. Leelahavanichkul K, et al. A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis. Mol Oncol. 2014 Feb;8(1):105-18. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6495 mL	13.2475 mL	26.4950 mL	66.2374 mL
	5 mM	0.5299 mL	2.6495 mL	5.2990 mL	13.2475 mL
	10 mM	0.2649 mL	1.3247 mL	2.6495 mL	6.6237 mL
	15 mM	0.1766 mL	0.8832 mL	1.7663 mL	4.4158 mL
	20 mM	0.1325 mL	0.6624 mL	1.3247 mL	3.3119 mL
	25 mM	0.1060 mL	0.5299 mL	1.0598 mL	2.6495 mL
	30 mM	0.0883 mL	0.4416 mL	0.8832 mL	2.2079 mL
	40 mM	0.0662 mL	0.3312 mL	0.6624 mL	1.6559 mL
	50 mM	0.0530 mL	0.2649 mL	0.5299 mL	1.3247 mL

Adezmapimod

626 Cited Publications

100 mg 견적 받기

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Adezmapimod

Reprogramming Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Cytoskeleton Compound Library

Anti-Lung Cancer Compound Library

Anti-Cancer Metabolism Compound Library

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Mitochondria-Targeted Compound Library

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Human Metabolite Library

Anti-Prostate Cancer Compound Library

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Heterocyclic Compound Library

Pain-Related Compound Library

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Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

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Serine/Threonine Kinase Inhibitor Library

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Mitophagy Compound Library

Bioactive Compound Library Max

Kinase Inhibitor Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Mass Spectrometry Human Metabolite Library

Posttranslational Modification Library

Lactylation Compound Library

Anti-Aging Compound Library Mini

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Metabolism/Protease Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Publications Citing Use of MedChemExpress (MCE) Adezmapimod

All p38 MAPK Isoforms

All HSP Isoforms

Biological Activity

Chemical Information

Publications (626)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Adezmapimod Related Classifications

HY-10256 Related Classifications